Antimicrobial Resistance and Global Health

Baloch, Zulqarnain; Aslam, Bilal; Yasmeen, Nafeesa; Ali, Amjad; Liu, Zewen; Rahaman, Abdual; Ma, Zhiyong

doi:10.1007/978-3-030-05325-3_103-1

Cited by 2 publications

(1 citation statement)

References 65 publications

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“…The discovery of penicillin marked a major turning point in the treatment of infectious diseases, saving countless lives and ushering in the era of antibiotics. However, the overuse of antibiotics has led to the emergence of antibiotic-resistant bacteria, posing a major challenge for modern medicine [10].…”

Section: History Background 21 First Antibioticsmentioning

confidence: 99%

Antibiotics synthesis: history and modern applications

Tong,

Zhang,

Zhang

et al. 2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

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Antibiotics have played a vital role in modern medicine by saving millions of lives. This review overviews the history of the development of antibiotics and highlights the potential of chemical synthesis technology to create novel and effective antibiotics to tackle the challenges posed by antibiotic-resistant bacteria. Ongoing research aims to develop new approaches to exploit the capabilities of chemical synthesis technology to address the growing threat of antibiotic resistance.

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Section: History Background 21 First Antibioticsmentioning

confidence: 99%

Antibiotics synthesis: history and modern applications

Tong,

Zhang,

Zhang

et al. 2024

Third International Conference on Biological Engineering and Medical Science (ICBioMed2023)

View full text Add to dashboard Cite

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Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain

Koutsoumanis¹,

Allende²,

Álvarez‐Ordóñez³

et al. 2021

EFS2

117

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The role of food-producing environments in the emergence and spread of antimicrobial resistance (AMR) in EU plant-based food production, terrestrial animals (poultry, cattle and pigs) and aquaculture was assessed. Among the various sources and transmission routes identified, fertilisers of faecal origin, irrigation and surface water for plant-based food and water for aquaculture were considered of major importance. For terrestrial animal production, potential sources consist of feed, humans, water, air/dust, soil, wildlife, rodents, arthropods and equipment. Among those, evidence was found for introduction with feed and humans, for the other sources, the importance could not be assessed. Several ARB of highest priority for public health, such as carbapenem or extended-spectrum cephalosporin and/or fluoroquinolone-resistant Enterobacterales (including Salmonella enterica), fluoroquinolone-resistant Campylobacter spp., methicillin-resistant Staphylococcus aureus and glycopeptide-resistant Enterococcus faecium and E. faecalis were identified. Among highest priority ARGs bla CTX-M , bla VIM , bla NDM , bla OXA-48like , bla OXA-23 , mcr, armA, vanA, cfr and optrA were reported. These highest priority bacteria and genes were identified in different sources, at primary and post-harvest level, particularly faeces/manure, soil and water. For all sectors, reducing the occurrence of faecal microbial contamination of fertilisers, water, feed and the production environment and minimising persistence/recycling of ARB within animal production facilities is a priority. Proper implementation of good hygiene practices, biosecurity and food safety management systems is very important. Potential AMR-specific interventions are in the early stages of development. Many data gaps relating to sources and relevance of transmission routes, diversity of ARB and ARGs, effectiveness of mitigation measures were identified. Representative epidemiological and attribution studies on AMR and its effective control in food production environments at EU level, linked to One Health and environmental initiatives, are urgently required.

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Antimicrobial Resistance and Global Health

Cited by 2 publications

References 65 publications

Antibiotics synthesis: history and modern applications

Antibiotics synthesis: history and modern applications

Role played by the environment in the emergence and spread of antimicrobial resistance (AMR) through the food chain

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