Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections

Vihta, Karina-Doris; Gordon, N Claire; Stoesser, Nicole; Quan, T Phuong; Tyrrell, Carina S.B.; Vongsouvath, Manivanh; Ashley, Elizabeth A.; Chansamouth, Vilada; Turner, Paul; Ling, Clare; Eyre, David W; White, Nicholas J.; Crook, Derrick W.; Peto, Tim; Walker, A Sarah

doi:10.1038/s41598-021-02755-5

Cited by 7 publications

(2 citation statements)

References 21 publications

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“…This study investigated the fungi associated with dried samples of Tomatoes using the two developed dryers Hybrid (PVT) and Solar Thermal (ST) solar Thermal respectively, the result revealed the presence of some fungi. The fungi isolated were S.cereviceae, S.pombe, F.oxyspurum and F.solani, the result revelled that F.solani has the highest frequency of occurrence with 28 % while S. pombe has the lowest occurrence of 3.45.The result in table 5and shows the frequency occurrence of fungi in the two different samples (Karina et al, 2021).…”

Section: Identification and Isolation Of Fungimentioning

confidence: 86%

Comparative Performance Evaluation of PVT Assisted Dryer And Conventional Solar Thermal Dryer In Drying of Tomatoes (Lycopersicon Esculentum)

Mohammad,

Danshehu, Bagudu,

Bayawa

et al. 2023

IJSGS

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Drying is an essential post-harvest preservation method for agricultural produce. Since drying is an energy absorbing process, farmers need to have access to effective dying techniques in order to maintain the quality of the products and maximize their profit. Hence, A Solar hybrid (PV/T) assisted dryer was designed, constructed and evaluated for drying of Tomatoes (Lycopersicon Esculentum). The load test drying efficiency of Solar Hybrid (PV/T) dryer was compared to Conventional Solar Thermal Dryer. The daily average moisture content reduction of tomatoes was 0.47g±0.169 while Solar thermal showed average reduction of 0.437g±0.188 for 35 and 37 hours respectively. The result of- t-test revealed there was no significant difference in the daily average drying rate between the hybrid (PV/T) and Solar thermal dryer. The results from the three models indicated moisture content reduction on daily basis shows that polynomial model has the highest (R²=0.9937, R²=0.9975) value and this implies that the average daily moisture content reduction of tomatoes for hybrid (PV/T) and solar thermal dryer were best described by polynomial model. The result of the proximate analysis conducted for the dried tomatoes sample using (PV/T) hybrid dryer and Solar thermal dryer indicated that ash content (5.3%), moisture content (13.31%), lipid (0.87), protein (8.87%), fiber (5.48%) `was significantly lower in sample dried with solar thermal dryer, while the lipid content (0.64%) and available carbohydrates (62.3%) are lower in tomato dried with Solar thermal dryer. The mycology test conducted for the fresh and dried tomatoes samples revealed the presence of the following fungi; S. cireviceae, S. Pombe, F. oxyspurum and F. solani with highest frequency of occurrence of S. solani (28%) and S. Pombe with lowest (3.96%) respectively. The collection efficiency of the dryer on drying of 4kg tomato sample was 42.49 %, pickup efficiency 36.89% and System efficiency 5.63%. The result obtained showed that PVT hybrid dryer is better option for drying compared to solar thermal dryer.

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Section: Identification and Isolation Of Fungimentioning

confidence: 86%

Comparative Performance Evaluation of PVT Assisted Dryer And Conventional Solar Thermal Dryer In Drying of Tomatoes (Lycopersicon Esculentum)

Mohammad,

Danshehu, Bagudu,

Bayawa

et al. 2023

IJSGS

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“…We designed a flexible R script to convert minimum inhibitory concentrations (MIC) in the monitoring systems to resistant/susceptible labels using CLSI and EUCAST thresholds and aggregate AMR estimates across monitoring systems for any chosen combination of countries, years, bacteria, and antibiotics. All isolates were aggregated regardless of the sample source (blood, urine, stool etc…), as previous work has suggested resistance profiles are similar for commensal opportunistic pathogens across different sample sources [15].…”

Section: Data Reformatting and Combinationmentioning

confidence: 99%

Investigating the feasibility and potential of combining industry AMR monitoring systems: a comparison with WHO GLASS

Rahbé,

Kovacevic,

Opatowski

et al. 2024

Preprint

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BackgroundEfforts to estimate the global burden of antimicrobial resistance (AMR) have highlighted gaps in existing surveillance systems. Data gathered from hospital networks globally by pharmaceutical industries to monitor antibiotic efficacy in different bacteria represent an additional source to track the temporal evolution of AMR. Here, we analysed available industry monitoring systems to assess to which extent combining them could help fill the gaps in our current understanding of AMR levels and trends.MethodsWe analysed six industry monitoring systems (ATLAS, GEARS, SIDERO-WT, KEYSTONE, DREAM, and SOAR) obtained from the Vivli platform and reviewed their respective isolates collection and analysis protocols. Using the R software, we designed a pipeline to harmonise and combine these into a single dataset. We assessed the reliability of resistance estimates from these sources by comparing the combined dataset to the publicly available subset of WHO GLASS for shared bacteria-antibiotic-country-year combinations.ResultsCombined, the industry monitoring systems cover 18 years (4 years for GLASS), 85 countries (71), 412 bacterial species (8), and 75 antibiotics (25). Although all industry systems followed a similar centralised testing approach, the criteria for isolate collection were unclear (patients selection, associated sampling periods...). ForE.coli,K. pneumoniaeandS. aureus, at least 65% of comparable resistance proportions were within 0.1 of the corresponding estimate in GLASS. We did not identify systemic bias towards resistance in industry systems compared to GLASS.ConclusionsCombining industry monitoring systems can substantially strengthen our knowledge of global AMR burden across bacterial species and countries. High agreement values for available comparisons with GLASS suggest that data for other bacteria-antibiotic-country-year combinations only present in industry systems could complement GLASS, particularly for Priority Pathogens currently not covered. This valuable information on resistance levels could help clinicians and stakeholders prioritize testing and select appropriate antibiotics in settings with limited surveillance data.

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Controlled-diffusion centrifugal microfluidic for rapid antibiotic susceptibility testing

Pang,

Li,

Wang

et al. 2024

Analytica Chimica Acta

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Antimicrobial resistance in commensal opportunistic pathogens isolated from non-sterile sites can be an effective proxy for surveillance in bloodstream infections

Cited by 7 publications

References 21 publications

Comparative Performance Evaluation of PVT Assisted Dryer And Conventional Solar Thermal Dryer In Drying of Tomatoes (Lycopersicon Esculentum)

Comparative Performance Evaluation of PVT Assisted Dryer And Conventional Solar Thermal Dryer In Drying of Tomatoes (Lycopersicon Esculentum)

Investigating the feasibility and potential of combining industry AMR monitoring systems: a comparison with WHO GLASS

Controlled-diffusion centrifugal microfluidic for rapid antibiotic susceptibility testing

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