Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins

Sampaio, Jorge Luiz Mello; Gales, Ana Cristina

doi:10.1016/j.bjm.2016.10.002

Cited by 111 publications

(78 citation statements)

References 93 publications

(42 reference statements)

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“…Originated from mastitis or with faecal origin in E. coli and K. pneumoniae. There are several reports in human clinical E-ESBL of CTX-M-2, CTX-M-15, CTX-M and SHV in Brazil (Sampaio and Gales, 2016).…”

Section: South Americamentioning

confidence: 99%

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production – a threat around the world

Palmeira

Ferreira

2020

Heliyon

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Food producing animal is a global challenge in terms of antimicrobial resistance spread. Extended-spectrum betalactamase (ESBL)-producing Enterobacteriaceae are relevant opportunistic pathogens that may spread in many ecological niches of the One Health approach as human, animal and environment due to intestinal selection of antimicrobial resistant commensals in food production animals. Cattle production is a relevant ecological niche for selection of commensal bacteria with antimicrobial resistance from microbiota. Enterobacteriaceae show importance in terms of circulation of resistant-bacteria and antimicrobial resistance genes via food chain creating a resistance reservoir, setting up a threat for colonization of humans and consequent health risk. ESBL-producing Enterobacteriaceae are a threat in terms of human health responsible for life threatening outbreaks and silent enteric colonization of community populations namely the elder population. Food associated colonization is a risk difficult to handle and control. In a time of globalization of food trading, population intestinal colonization is a mirror of food production and in that sense this work aims to make a picture of ESBL-producing Enterobacteriaceae in animal production for food over the world in order to make some light in this reality of selection of resistant threats in food producing animal.

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Section: South Americamentioning

confidence: 99%

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production – a threat around the world

Palmeira

Ferreira

2020

Heliyon

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“…The identification of new compounds with antimicrobial action has aroused the interest of the pharmaceutical industry, especially because many strains of microorganisms have become resistant to currently available antimicrobial drugs, thereby resulting in high morbidity and mortality rates, especially among nosocomial infections [ 57 , 58 ]. Among the main mechanisms of resistance are the elimination of antibiotics by efflux pumps present in the cell wall of microorganisms [ 59 , 60 ] and the degradation of antibiotics by specific enzymes [ 61 ].…”

Section: Discussionmentioning

confidence: 99%

Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides

Santos

Campos

Santos

et al. 2017

Oxidative Medicine and Cellular Longevity

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Stingless bees produce geopropolis, which is popularly described for its medicinal properties, but for which few scientific studies have demonstrated pharmacological effects. The objective of this study was to investigate the chemical composition of the geopropolis of Melipona quadrifasciata anthidioides and to evaluate its antioxidant, antimutagenic, anti-inflammatory, and antimicrobial activities. The composition of the hydroethanolic extract of geopropolis (HEG) included di- and trigalloyl and phenylpropanyl heteroside derivatives, flavanones, diterpenes, and triterpenes. HEG showed antioxidant action via the direct capture of free radicals and by inhibiting the levels of oxidative hemolysis and malondialdehyde in human erythrocytes under oxidative stress. HEG also reduced the frequency of gene conversion and the number of mutant colonies of S. cerevisiae. The anti-inflammatory action of HEG was demonstrated by the inhibition of hyaluronidase enzyme activity. In addition, HEG induced cell death in all evaluated gram-positive bacteria, gram-negative bacteria, and yeasts, including clinical isolates with antimicrobial drug resistance. Collectively, these results demonstrate the potential of M. q. anthidioides geopropolis for the prevention and treatment of various diseases related to oxidative stress, mutagenesis, inflammatory processes, and microbial infections.

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“…These bacteria are resistant to practically all antibiotics (17) and are able to transmit resistance to other bacteria they come into contact with. In the present study, only one K. pneumoniae colony was isolated, where this proved KPC positive.…”

Section: Doctors Law Studensmentioning

confidence: 99%

Microbiological investigation of ties and shirts in a Teaching Hospital, in São Paulo (SP), Brazil /Investigação microbiológica entre diferentes indumentárias em Hospital Escola em São Paulo (SP) Brasil

Ribeiro

Navarini

Marcato

2019

Arq Med Hosp Fac Cienc Med Santa Casa São Paulo

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Objectives: In this article, we aim to compare the contamination rates between neckties physicians in a large Brazilian hospital to those of lawyers. We also intend to compare the contamination rates between neckties and shirts from those two groups. We believe that neckties often serve as a fomite, carrying potentially harmful bacteria and, directly or indirectly, contaminate patients. Methods: We collected swab samples from doctors´ neckties and shirts at a large teaching hospital in São Paulo city center and assessed their degree of contamination. The findings were compared against necktie and shirt swab samples taken from law students (control group) of a University in Sao Paulo city center. The contamination levels of both fomites were assessed, together with the susceptibility profile of bacteria not from normal microbiota. Results: Contamination of doctors´ neck ties was greater than that of law students´ neckties (p<0.05), where pathogenic bacteria were detected in both groups. No statistically significant difference in contamination of shirts was found between the groups. Bacteria that make up normal human microbiota (Staphylococcus epidermidis, Staphylococcus aureus, Micrococcus sp, and Bacillus subtilis) were the most prevalent. Conclusions: In this study, both pathogenic bacteria and normal microbiota bacteria were found, highlighting the susceptibility of neck ties of doctors and law students to bacterial contamination. These garments can act as a vehicle for spreading antibiotic-resistant bacteria in the community.Keywords: Microbiology, Cross Infection, Fomites, Clotings, Humans RESUMOIntrodução: Diversos objetos podem agir como fômites para a contaminação bacteriana. Jalecos, aventais e camisas são normalmente higienizados, enquanto gravatas não. Estas poderiam transportar microorganismos capazes de colonizar outras áreas e, direta ou indiretamente, contaminar indivíduos debilitados. Assim, mesmo médicos que realizam higienização adequada das mãos podem se recontaminar pelo contato com gravatas. Materiais e métodos: Coletamos amostras com swabs das gravatas e camisas dos médicos de um hospital escola de grande porte no centro de São Paulo e avaliamos seu grau de contaminação. Comparamos os achados a um grupo controle com swabs de gravatas e camisas de estudantes de direito de uma universidade no centro de São Paulo. avaliamos as possibilidades da contaminação das foram avaliadas para ambos os fômites, além do perfil de sensibilidade das bactérias que não pertencem à microbiota normal. Resultados: A contaminação das gravatas de médicos foi superior à de advogados (p<0,05), evidenciando bactérias patogênicas em ambos os grupos. Não houve diferença estatisticamente significante na contaminação de camisas entre os grupos. Bactérias que compõem a microbiota normal humana foram mais frequentes (Staphylococcus epidermidis, Staphyococcus aureus, Micrococcus sp, bacilo Subtilis). Discussão: Neste estudo, encontramos bactérias patogênicas e bactérias da microbiota normal, evidenciando a susceptibilidade das gravatas de médicos e estudantes de medicina à contaminação bacteriana, podendo atuar na comunidade como meio de transporte para bactérias resistentes aos antibióticos.Descritores: Microbiologia, Infecção Hospitalar, Fômites, Roupas, Humanos

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Antimicrobial resistance in Enterobacteriaceae in Brazil: focus on β-lactams and polymyxins

Cited by 111 publications

References 93 publications

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production – a threat around the world

Extended-spectrum beta-lactamase (ESBL)-producing Enterobacteriaceae in cattle production – a threat around the world

Chemical Composition and Pharmacological Effects of Geopropolis Produced by Melipona quadrifasciata anthidioides

Microbiological investigation of ties and shirts in a Teaching Hospital, in São Paulo (SP), Brazil /Investigação microbiológica entre diferentes indumentárias em Hospital Escola em São Paulo (SP) Brasil

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