Antimicrobial Resistance in Hospital-Acquired Gram-Negative Bacterial Infections

Mehrad, Borna; Clark, Nina M.; Zhanel, George G.; Lynch, Joseph P.

doi:10.1378/chest.14-2171

Cited by 185 publications

(160 citation statements)

References 75 publications

(31 reference statements)

Supporting

Mentioning

151

Contrasting

Unclassified

Order By: Relevance

“…It must be noted that 'solubility' of the complexes, and hence higher Bi concertation in water,m ay be due to their instability in water. 1 HNMR spectral analysis on the solubilised component from the addition of complex 5 to water shows more than one speciesp resent. Rather than observing the single expected bis-phosphinatoc omplex…”

Section: Synthesis and Characterisationmentioning

confidence: 99%

“…Reaction of each phosphinic acid with BiPh 3 at reflux in ethanol (or heating in DMSO) resultsi nt he protonation and elimination to two equivalents of benzene (PhH) generating the heteroleptic bis-phosphinato complexes [PhBi(OP(=O)R 1 R 2 ) 2 ]a s poorly soluble white solids, (1,(3)(4)(5), in moderate to high yields (Table 1). However,f ollowing this simple solvent-based approach the reactionw ith bis(4-methoxyphenyl)phosphinic acid (ii)i nvariably produces mixtures of the mono and bis-substituted phosphinato complexes.…”

Section: Synthesis and Characterisationmentioning

confidence: 99%

“…The likelihood of being infected by multi‐drug resistant bacteria is highest in hospitals and healthcare facilities . The rise of antimicrobial resistance (AMR) means that formerly easily treatable infections are becoming, once‐again, life threatening.…”

Section: Introductionmentioning

confidence: 99%

“…The likelihood of being infected by multi-drug resistant bacteria is highest in hospitals andh ealthcare facilities. [1,2] The rise of antimicrobialr esistance (AMR) meanst hat formerlye asily treatable infections are becoming, once-again,l ife threatening. Evidence indicates that contaminated surfaces in hospitals and healthcare facilities significantly contribute to the transmission of infection.…”

Section: Introductionmentioning

confidence: 99%

See 3 more Smart Citations

Bismuth Phosphinates in Bi‐Nanocellulose Composites and their Efficacy towards Multi‐Drug Resistant Bacteria

Werrett

Herdman

Brammananth

et al. 2018

Chemistry A European J

View full text Add to dashboard Cite

A series of poorly soluble phenyl bis-phosphinato bismuth(III) complexes [BiPh(OP(=O)R R ) ] (R =R =Ph; R =R =p-OMePh; R =R =m-NO Ph; R =Ph, R =H; R =R =Me) have been synthesised and characterised, and shown to have effective antibacterial activity against Escherichia coli (E. coli), Staphylococcus aureus (S. aureus), methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE). The bismuth complexes were incorporated into microfibrillated (nano-) cellulose generating a bismuth-cellulose composite as paper sheets. Antibacterial evaluation indicates that the Bi-cellulose materials have analogous or greater activity against Gram positive bacteria when compared with commercial silver based additives: silver sulfadiazine loaded at 0.43 wt % into nanocellulose produces a 10 mm zone of inhibition on the surface of agar plates containing S. aureus whereas [BiPh(OP(=O)Ph ) ] loaded at 0.34 wt % produces an 18 mm zone of inhibition. These phenyl bis-phosphinato bismuth(III) complexes show potential to be applied in materials in healthcare facilities, to inhibit the growth of bacteria capable of causing serious disease.

show abstract

Section: Synthesis and Characterisationmentioning

confidence: 99%

Section: Synthesis and Characterisationmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Bismuth Phosphinates in Bi‐Nanocellulose Composites and their Efficacy towards Multi‐Drug Resistant Bacteria

Werrett

Herdman

Brammananth

et al. 2018

Chemistry A European J

View full text Add to dashboard Cite

show abstract

“…Gram-negative bacilli colonize the upper aerodigestive tract as part of the normal response to acute illness and cause pneumonia when introduced into the lower respiratory tract by micro-aspiration (1, 2). The progressive rise in antibiotic resistance amongst the causative organisms in recent decades has markedly diminished the available treatment options for these infections, lending new impetus to mechanistic studies that may inform the development of better therapeutic strategies.…”

Section: Introductionmentioning

confidence: 99%

M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes

Bettina

Zhang

Michels

et al. 2016

The Journal of Immunology

Self Cite

View full text Add to dashboard Cite

Gram-negative bacterial pneumonia is a common and dangerous infection with diminishing treatment options due to increasing antibiotic resistance among causal pathogens. The mononuclear phagocyte system is a heterogeneous group of leukocytes composed of tissue-resident macrophages, dendritic cells and monocyte-derived cells that are critical in defense against pneumonia, but mechanisms that regulate their maintenance and function during infection are poorly defined. Macrophage-colony stimulating factor (M-CSF) has myriad effects on mononuclear phagocytes but its role in pneumonia is unknown. We therefore tested the hypothesis that M-CSF is required for mononuclear phagocyte-mediated host defenses during bacterial pneumonia in a murine model of infection. Genetic deletion or immunoneutralization of M-CSF resulted in reduced survival, increased bacterial burden and greater lung injury. M-CSF was necessary for the expansion of lung mononuclear phagocytes during infection but did not affect the number of bone marrow or blood monocytes, the proliferation of precursors or the recruitment of leukocytes to the lungs. In contrast, M-CSF was essential to survival and anti-microbial functions of both lung and liver mononuclear phagocytes during pneumonia and its absence resulted in bacterial dissemination to the liver and hepatic necrosis. We conclude that M-CSF is critical to host defenses against bacterial pneumonia by mediating survival and anti-microbial functions of mononuclear phagocytes in the lungs and liver.

show abstract

Antimicrobial Therapy

Levy¹,

Chávez²,

Rosenberg³

2020

Mount Sinai Expert Guides

View full text Add to dashboard Cite

Antimicrobial Resistance in Hospital-Acquired Gram-Negative Bacterial Infections

Cited by 185 publications

References 75 publications

Bismuth Phosphinates in Bi‐Nanocellulose Composites and their Efficacy towards Multi‐Drug Resistant Bacteria

Bismuth Phosphinates in Bi‐Nanocellulose Composites and their Efficacy towards Multi‐Drug Resistant Bacteria

M-CSF Mediates Host Defense during Bacterial Pneumonia by Promoting the Survival of Lung and Liver Mononuclear Phagocytes

Antimicrobial Therapy

Contact Info

Product

Resources

About