Antimicrobial Resistance in Campylobacterjejuni and Campylobacter coli Strains Isolated in 1991and 2001-2002 from Poultry and Humans in Berlin,Germany

Abstract

The susceptibilities of 430 Campylobacter jejuni strains and 79 C. coli strains to six antimicrobial agents were tested and analyzed. The two sets of strains originated from retail market chicken and turkey samples and from humans, respectively, in Berlin, Germany. Two groups of isolates, one dating from 1991 and the other dating from 2001-2002, were tested. Of the Campylobacter sp. isolates recovered from humans in 2001-2002, 45.1% were resistant to ciprofloxacin, 37.8% were resistant to tetracycline, 12.8% were resistant to ampicillin, and 50.0% were resistant to trimethoprim-sulfamethoxazole. All isolates were susceptible to gentamicin, while the overall rate of resistance to erythromycin was 6.1%. During the 10 years between the two sampling times, the rates of resistance to ciprofloxacin (P < 0.001), ampicillin (P ‫؍‬ 0.035), and tetracycline (P ‫؍‬ 0.01) increased significantly among strains isolated from humans. Furthermore, among human C. coli strains the rate of resistance to erythromycin rose from 7.1% in 1991 to 29.4% in 2001-2002. In comparison, Campylobacter sp. isolates from poultry already had high rates of resistance in 1991. Different rates of resistance to tetracycline among isolates from chickens and turkeys suggested the development of resistance during antimicrobial treatment in food animals. Thus, discrepancies in the antimicrobial resistance rates among Campylobacter isolates originating from poultry and humans support the hypothesis that at least some of the resistant Campylobacter strains causing infection in humans come from sources other than poultry products.

Prevalence and Antimicrobial Resistance of <i>Campylobacter</i> Isolates from Beef Cattle and Pigs in Japan

“…In this study, antimicrobial resistance of C. coli isolates to EM from pigs (P<0.05, chi-square test with Yete's correction for continuity) was significantly higher than that from beef cattle. Luber et al [11] suggested that pigs were a likely source for EM-resistant C. coli infections in humans. Harada et al [5] reported that EM resistant C. coli isolates increased slightly but constantly from 1999 to 2004 and suggested that the dynamics of EM resistance in porcine C. coli isolates should be noticed for risk management of antimicrobial resistance in Campylobacter.…”

Resistance to erythromycin of Campylobacter jejuni and Campylobacter coli isolated from animals and humans

“…In 1998, 3% C. jejuni/coli resistant strains were reported in Canada, but the percentage rose to 12% in 2001 (Gaudreau and Michaud, 2003). In Germany, 7.1 and 29.4% C. coli resistant to erythromycin were reported in 1991 and 2001, respectively (Luber et al, 2003). Besides, a rising trend of resistance to erythromycin was reported in Northern Ireland, from 0.6% in 1996 to 4.2% in 2000 (Moore et al, 2001).…”

“…isolated from humans has become allarming (Bywater et al, 2004;Cardinale et al, 2002). Emergence of the resistant strains coincided with the beginning of macrolides use, for the most part thylosine, in veterinary medicine, mainly in swine farming ( Aarestrup and Engberg, 2001;Luber et al, 2003).…”

Bacterial pathogens associated with infectious diarrhea in King Khalid University Hospital, Riyadh Saudi Arabia 2005-2010

“…It is lowest in Canada (12%) and Germany (0%) (C. jejuni) (Gibreel et al, 2005;Gaudreau and Gilbert, 2003;Luber et al, 2003) and highest in Taiwan (C. coli) 50% (Li et al, 1998) and Nigeria 79.8% . However a study on macrolide resistance in C. jejuni in Sweden showed stable pattern (Engberg et al, 2001;Osterlund et al, 2003).…”