Antimicrobial resistance in <i>Salmonella</i> that caused foodborne disease outbreaks: United States, 2003–2012

Brown, Allison C; Grass, Julian; Richardson, L. C.; Nisler, Amie; Bicknese, Amelia; Gould, L. Hannah

doi:10.1017/s0950268816002867

Cited by 37 publications

(29 citation statements)

References 24 publications

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“…The increase in multi-antimicrobial-resistant Salmonella strains isolated from humans has been associated with the widespread use of antimicrobial agents in food animal production (Brown et al 2017). The spread of antimicrobial resistance through the food chain is regarded as a major public health issue (Raufu et al 2014).…”

Section: Discussionmentioning

confidence: 99%

Survey of Salmonella spp. in beef meat for export at slaughterhouses in Brazil

et al. 2018

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The aim of the present study was to investigate the presence of Salmonella spp. in samples collected from beef meat at three points of the slaughter line (after skinning, washing and cooling) at three slaughterhouses in Brazil that export meat. Detection was based on ISO 6579:2002 and confirmed by PCR and qPCR. The isolates were typified using slide agglutination tests and PFGE. The antibiotic sensitivity profile was determined using the disk diffusion method. Contamination was detected in only one slaughterhouse. The overall frequency of contamination by Salmonella spp. was 6.7% of carcasses (6/90) and 2.6% of carcass surface samples (7/270). All isolates were confirmed by PCR and qPCR. The serological analysis and the PFGE showed a single profile: Typhimurium. The strains demonstrated 100% susceptibility to ampicillin, cefotaxime, ciprofloxacin, chloramphenicol, gentamicin and tetracycline. Positive carcasses after cooling pose a direct risk to consumers, since the meat is considered ready to be marketed after this process.

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Section: Discussionmentioning

confidence: 99%

Survey of Salmonella spp. in beef meat for export at slaughterhouses in Brazil

et al. 2018

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“…Increasing antibiotic resistance among foodborne pathogens is an emerging problem of global health importance [ 1 ] and the overuse of antibiotics in food animal production has been reported as one of its major drivers [ 2 ]. Colistin is a critically important antimicrobial in veterinary medicine [ 2 ], and is considered the drug of last resort against the emergent multidrug resistant (MDR) Gram-negative bacterial infections in humans, especially the carbapenem-resistant Enterobacteriaceae [ 3 ].…”

Section: Introductionmentioning

confidence: 99%

Antibiogram Profiles and Risk Factors for Multidrug Resistance of Salmonella enterica Recovered from Village Chickens (Gallus gallus domesticus Linnaeus) and Other Environmental Sources in the Central and Southern Peninsular Malaysia

et al. 2020

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The emergence of multidrug resistance (MDR), including colistin resistance, among Enterobacteriaceae recovered from food animals poses a serious public health threat because of the potential transmission of these resistant variants to humans along the food chain. Village chickens or Ayam Kampung are free-range birds and are preferred by a growing number of consumers who consider these chickens to be organic and more wholesome. The current study investigates the antibiogram profiles of Salmonella isolates recovered from village chicken flocks in South-central Peninsular Malaysia. A total of 34 isolates belonging to eight serotypes isolated from village chickens were screened for resistance towards antimicrobials including colistin according to the WHO and OIE recommendations of critical antibiotics. S. Weltevreden accounted for 20.6% of total isolates, followed by serovars Typhimurium and Agona (17.6%). The majority of isolates (73.5%) demonstrated resistance to one or more antimicrobials. Eight isolates (23.5%) were resistant to ≥3 antimicrobial classes. Colistin resistance (minimum inhibitory concentrations: 4–16 mg/L) was detected among five isolates (14.7%), including S. Weltevreden, S. Albany, S. Typhimurium, and Salmonella spp. Univariable analysis of risk factors likely to influence the occurrence of MDR Salmonella revealed that the flock size, poultry production system, and use of antibiotics in the farm were not significantly (p > 0.05) associated with MDR Salmonella. The current study highlights that MDR Salmonella occur at a lower level in village chickens compared to that found in live commercial chickens. However, MDR remains a problem even among free-range chickens with minimal exposure to antibiotics.

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“…To treat Salmonella infections, antibiotics are generally used in modern clinical treatment. However, with the overuse of antibiotics, bacteria had developed resistance against almost all kind of drugs [9]. Therefore, new therapeutic drugs are urgently needed for clinical treatment.…”

Section: Introductionmentioning

confidence: 99%

Study on inhibitory effect of cinnamaldehyde on Salmonella based on iTRAQ technology

Liang¹,

Chen²,

He³

et al. 2020

Preprint

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BackgroundSalmonella is one of the most concerned pathogenic bacterium worldwide. In our previous experiments, cinnamaldehyde showed prominent antibacterial effects on Salmonella Typhimurium (S. Typhimurium), indicating that it could be developed as a novel therapeutic drugs for Salmonella.ResultsIn this assay, the mechanism of cinnamaldehyde inhibiting S. Typhimurium was investigated. We studied the antibacterial mechanism of cinnamaldehyde using isobaric tags for relative and absolute quantification (iTRAQ) with two-dimensional liquid chromatography/tandem mass spectrometry (2D-LC-MS/MS), combining with bioinformatics. There were 2,212 proteins detected by iTRAQ, of which 73 proteins were up-regulated, and 82 of proteins were down-regulated. The differently expressed proteins were connected with 10 cellular components, 9 molecular functions and 13 biological processes as well as 57 Kyoto Encyclopedia of Genes and Genomes (KEGG) pathways. There were some differently expressed proteins involved into biosynthesis and metabolism of amino, redox reaction, energy metabolism, toxins and drug-resistance. Cinnamaldehyde may have the potential to become a novel drug for Salmonella infection.ConclusionsBased on the iTRAQ technology, this paper explores the mechanism of cinnamaldehyde on Salmonella typhimurium at the protein level, digs the target of action, lays a theoretical foundation for further exploration, and provides new ideas for the clinical use and development of cinnamaldehyde.Therefore, cinnamaldehyde may have the potential to be used combined with antibiotics.

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Antimicrobial resistance in Salmonella that caused foodborne disease outbreaks: United States, 2003–2012

Cited by 37 publications

References 24 publications

Survey of Salmonella spp. in beef meat for export at slaughterhouses in Brazil

Survey of Salmonella spp. in beef meat for export at slaughterhouses in Brazil

Antibiogram Profiles and Risk Factors for Multidrug Resistance of Salmonella enterica Recovered from Village Chickens (Gallus gallus domesticus Linnaeus) and Other Environmental Sources in the Central and Southern Peninsular Malaysia

Study on inhibitory effect of cinnamaldehyde on Salmonella based on iTRAQ technology

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