Antimicrobial Resistance in Nontyphoidal Salmonellae

McDermott, Patrick F.

doi:10.1128/9781555817534.ch17

Cited by 13 publications

(13 citation statements)

References 208 publications

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“…In humans, salmonellosis is usually a self‐limiting diarrhoea that does not warrant antimicrobial therapy. However, these infections can also lead to life‐threatening systemic infections that require effective chemotherapy (McDermott ). Fluoroquinolones and extended‐spectrum cephalosporins are the agents of choice for such chemotherapy (NARMS, ).…”

Section: Discussionmentioning

confidence: 99%

“…Salmonella enterica subsp. enterica serovar Typhimurium ( Salmonella Typhimurium) has a broad host range and is one of the most common serovars in food animals and humans (McDermott ). Over the past 50 years, this serovar has often been characterized by successive waves of dominant multidrug‐resistant clones (McDermott ; Petrovska et al ).…”

Section: Introductionmentioning

confidence: 99%

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Trends in the serovar and antimicrobial resistance in clinical isolates of Salmonella enterica from cattle and pigs between 2002 and 2016 in Japan

et al. 2019

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Aims Given the significance of Salmonella enterica in both human and animal health, and a recent global dissemination of Salmonella 4,[5],12:i:‐, changes in the prevalent serovars and antimicrobial resistance in clinical isolates of Salmonella from cattle and pigs were investigated in Japan. Methods and Results The serovars and antimicrobial susceptibilities of 1605 Salmonella enterica isolated from cattle (n = 894) and swine (n = 711) between 2002 and 2016 were examined. The most common serovar among all samples was Salmonella Typhimurium. However, its monophasic variant with antigenic structure S. 4,[5],12:i:‐, which was first detected in cattle in 2006 and swine in 2010, has been rapidly increasing in incidence and resistance. Resistance rates to cefotaxime and ciprofloxacin were generally low (<10% in the cattle isolates and <5% in the swine isolates); however, isolates resistant to more than five antimicrobials, which often include these antimicrobials, were recently detected in Salmonella Dublin, S. 4,[5],12:i:‐, S. Typhimurium, Salmonella Newport, Salmonella Choleraesuis and Salmonella 6,7:c:‐. Among them, two S. 4,[5],12:i:‐ isolates possessed extended‐spectrum β‐lactamase‐encoding genes; blaSHV‐12 or blaCTX‐M‐55, respectively, while all the five S. Typhimurium isolates possessed AmpC‐type β‐lactamase gene of blaCMY‐2. Conclusions S. 4,[5],12:i:‐ has been rapidly increasing and exhibiting a remarkable change in antimicrobial resistance in Japan. Considering certain serovars are characterized by multidrug resistance including medically important antimicrobials, continuous monitoring and appropriate measures are required to protect public health and veterinary husbandry. Significance and Impact of the Study This study presents a trend in the serovars and antimicrobial resistance in clinical isolates of Salmonella from cattle and pigs in Japan, and showed that there were certain types of Salmonella serovars depending on the animal origin which needs more attention.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Trends in the serovar and antimicrobial resistance in clinical isolates of Salmonella enterica from cattle and pigs between 2002 and 2016 in Japan

et al. 2019

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“…Over the years, ampicillin, chloramphenicol, and cotrimoxazole (trimethoprim/sulfamethoxazole) were first-line antimicrobials for treatment of severe salmonellosis [ 1 , 44 ], but in developing countries like Ghana, chloramphenicol, fluoroquinolone, or third-generation cephalosporins are now commonly used as ampicillin, and cotrimoxazole have become ineffective due to development of resistance [ 25 , 45 ]. Our susceptibility testing indicates moderate resistance to chloramphenicol (33.9%) and fluoroquinolones (25.0%), which means that although they are still a useful choice for empirical treatment of blood stream infections with Salmonella in Ghana, care must be taken to maintain or minimize increase in resistance.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and characterization of Salmonella among humans in Ghana

et al. 2017

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BackgroundNon-typhoidal Salmonella (NTS) is a public health problem worldwide and particularly in Africa with high disease burden. This study characterized Salmonella isolates from humans in Ghana to determine serovar distribution, phage types, and antimicrobial resistance. Further, the clonal relatedness among isolates was determined.MethodsOne hundred and thirty-seven Salmonella isolates (111 clinical and 26 public toilet) were characterized using standard serotyping, phage typing, and antimicrobial susceptibility testing methods. The molecular epidemiology of common serovars (Salmonella Typhimurium and Salmonella Enteritidis) was established by pulsed field gel electrophoresis (PFGE).ResultsTwenty-two serovars were identified with S. Enteritidis, S. Typhimurium, and Salmonella Derby as the most dominant. One hundred and twelve isolates showed resistance to more than one antimicrobial. Fifty-eight (n = 58/112; 54.5%) strains were multi-resistant with low resistance to cephalosporins ceftazidime (8.0%), cefotaxime (4.5%), and cefoxitin (2.7%) with synergy to clavulanic acid indicating possible ESBLs. Isolates showed high resistance to trimethoprim (66.1%), tetracycline (61.6%), ampicillin (57.1%), sulfamethoxazole (46.4%), chloramphenicol (33.9%), and ciprofloxacin (25.0%). The most common resistance pattern of multi-resistant serovars was to ampicillin, chloramphenicol, sulphonamide, and trimethoprim. S. Enteritidis (18/43) strains reacted with typing phages but did not conform to any phage type with PT14B and PT4 as predominant definitive phage types. Six S. Typhimurium strains reacted but did not conform to any recognized phage type while seven were non-typable. The predominant definitive phage types were DT1 and DT22. PFGE patterns of human S. Enteritidis were closely related to patterns of poultry isolates obtained in a previous study in Ghana.ConclusionsCephalosporin resistance is uncommon among Salmonella from humans in Ghana. Poultry may be an important source of human salmonellosis. There is an urgent need for the implementation of routine surveillance of antimicrobial use and bacterial resistance among humans in Ghana.

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“…The frequency and extent of resistance in Salmonella varies according to the antimicrobial use and the ecological differences in its epidemiology [ 67 ]. Some multidrug-resistant Salmonella strains with extensive resistance profiles pose greater threats to public health and have been associated with higher mortality and morbidity rates [ 41 ].…”

Section: Antimicrobial Resistance In Zoonotic Pathogens Associated With Poultry Productsmentioning

confidence: 99%

Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry

Saraiva

Lim²,

Monte

et al. 2021

Braz J Microbiol

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Antimicrobial Resistance in Nontyphoidal Salmonellae

Cited by 13 publications

References 208 publications

Trends in the serovar and antimicrobial resistance in clinical isolates of Salmonella enterica from cattle and pigs between 2002 and 2016 in Japan

Trends in the serovar and antimicrobial resistance in clinical isolates of Salmonella enterica from cattle and pigs between 2002 and 2016 in Japan

Prevalence and characterization of Salmonella among humans in Ghana

Antimicrobial resistance in the globalized food chain: a One Health perspective applied to the poultry industry

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