Antimicrobial resistance in patients with endodontic infections: A systematic scoping review of observational studies

Medina, C.M. Ardila; Bedoya-García, Jader-Alexander; González‐Arroyave, Daniel

doi:10.1111/aej.12680

Cited by 10 publications

(14 citation statements)

References 36 publications

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“…Low susceptibility to erythromycin was also previously described in endodontic infections [ 42 ], and the augmentation of anaerobic resistance to clindamycin was also indicated in a recent systematic scoping review [ 42 ] with outcomes consistent with the great resistance of Prevotella spp. against penicillin [ 43 ].…”

Section: Discussionmentioning

confidence: 66%

“…against penicillin [ 43 ]. These findings are predominantly caused by the facility for beta-lactamase production among anaerobes [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

“…Antibiotic resistance is an international challenge, wherein several nations are demonstrating greater resistance [ 42 , 44 ]. With this background, it is pertinent to emphasize that a current investigation denoted that antimicrobial-resistance genes were perceived in the plaque of more than 50% of healthy persons [ 45 ].…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review

Medina

Vivares-Builes

2022

IJERPH

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The implementation of adjunctive antibiotics has been recommended for the therapy of peri-implantitis (PI). In this review, antibiotic resistance patterns in PI patients were assessed. A systematic scoping review of observational studies and trials was established in conjunction with the PRISMA extension for scoping reviews. The SCOPUS, PubMed/MEDLINE, EMBASE, SCIELO, Web of Science, and LILACS databases were reviewed along with the gray literature. The primary electronic examination produced 139 investigations. Finally, four observational studies met the selection criteria. These studies evaluated 214 implants in 168 patients. Porphyromonas gingivalis and Fusobacterium nucleatum mainly presented high resistance to tetracycline, metronidazole, and erythromycin in PI patients. Similarly, Aggregatibacter actinomycetemcomitans was also highly resistant to clindamycin and doxycycline. Other microorganisms such as Tannerella forsythia, Parvimonas micra, and Prevotella intermedia/nigrescens also presented significant levels of resistance to other antibiotics including amoxicillin, azithromycin, and moxifloxacin. However, most microorganisms did not show resistance to the combination amoxicillin metronidazole. Although the management of adjunctive antimicrobials in the therapy of PI is controversial, in this review, the resistance of relevant microorganisms to antibiotics used to treat PI, and usually prescribed in dentistry, was observed. Clinicians should consider the antibiotic resistance demonstrated in the treatment of PI patients and its public health consequences.

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Section: Discussionmentioning

confidence: 66%

“…against penicillin [ 43 ]. These findings are predominantly caused by the facility for beta-lactamase production among anaerobes [ 42 ].…”

Section: Discussionmentioning

confidence: 99%

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Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review

Medina

Vivares-Builes

2022

IJERPH

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“…It is important to note that the heterogeneity of the randomized clinical trials examined in this systematic review precluded a more thorough study. Some recent systematic reviews [ 47 , 48 ] have revealed the exact same issues. The diverse behavior of systematic reviews, in terms of the clinical trials included, justifies the standardization of clinical techniques so that comparisons between clinical trials may be made without prejudice.…”

Section: Discussionmentioning

confidence: 87%

A Systematic Review of Randomized Clinical Trials Evaluating the Efficacy of Minimally Invasive Surgery for Soft Tissue Management: Aesthetics, Postoperative Morbidity, and Clinical Results

2023

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Background and Objectives: The necessity for less invasive and patient-friendly surgical therapies guided the development of the “minimally invasive surgical technique” (MIST). The aim of this systematic review was to evaluate the efficacy of MIST for soft tissue management considering aesthetic results, postoperative morbidity, and clinical outcomes. Materials and Methods: Several databases were used to conduct a thorough analysis of the scientific evidence. To investigate randomized clinical trials (RCTs), MeSH terms and keywords were provided. Results: Eleven RCTs were chosen. These experiments included 273 patients. The trials that explored MIST for papilla preservation presented greater efficacy in increasing papillary height (p < 0.05). MIST showed stable clinical outcomes for the management of excessive gingival display and with a flapless technique for single implant placement. Considering the treatment of gingival recessions, some RCTs presented greater root coverage with MIST (p < 0.05), while other trials did not show differences between groups. Regarding aesthetic perception, five RCTs indicated high patient satisfaction with MIST (p < 0.05). Similarly, six RCTs reported that patients in the MIST group presented significantly less post-surgical pain and lower wound healing scores (p < 0.01). Conclusions: It was concluded that using MIST resulted in more clinical studies reporting better clinical outcomes. Considering aesthetic appearance, slightly more than half of the clinical trials also showed improved results with MIST. Likewise, regarding postoperative morbidity, 60% of the clinical trials also described better scores with MIST. All of this indicates that MIST is a good alternative for the management of soft tissues.

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“…However, resistance to vancomycin was not observed in our collection. A systematic review by Ardilla et al [11], found no reports of vancomycin-resistant E. faecalis from root canals.…”

Section: Discussionmentioning

confidence: 99%

Diversity in endodontic Enterococcus faecalis from Brazil with high occurrence of ST 397 clone

LINS,

FREITAS,

VICENTE

2024

Preprint

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Objectives: The aim of this study was to assess the genetic relatedness of E. faecalis strains from primary endodontic infections in Brazil, test the hypothesis of clones infecting unrelated individuals, and examine the antimicrobial resistance profile. Materials and Methods: The genetic relationship of 32 endodontic E. faecalis were investigated by multilocus sequecing typing (MLST). These isolates were collected from unrelated patients with primary endodontic infection treated in Brazil between 2010 and 2023. Antimicrobial susceptibility testing was performed using the disk diffusion technique according to the Clinical Laboratory Standard Institute. Results: 12 sequence types (STs) were detected, of which 8 STs contained only one strain. We found clones of ST 30, ST40, ST 97 and ST 397, with a high frequency of the latter (15/32). Susceptibility to the antimicrobial agents tested varied, with the highest percentage of resistance observed for clindamycin (100%), tetracycline (34.4%), azithromycin (31.2%) and ciprofloxacin (19.2%). One isolate was multidrug resistant. Conclusions: MLST of endodontic E. faecalis showed clones infecting different individuals in different cities up to 10 years apart with high occurrence of ST 397. This data, together with the literature, raise the concern that there may be clones specialized in endodontic infections. Further MLST studies are needed, as well as surveillance for antimicrobial resistance in endodontic isolates. Clinical Relevance: Enterococcus faecalis is a common cause of nosocomial infections and is frequently associated with root canal infections. The identification of clones specialized in endodontic infections may lead to more effective therapeutic strategies.

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Antimicrobial resistance in patients with endodontic infections: A systematic scoping review of observational studies

Cited by 10 publications

References 36 publications

Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review

Antibiotic Resistance in Patients with Peri-Implantitis: A Systematic Scoping Review

A Systematic Review of Randomized Clinical Trials Evaluating the Efficacy of Minimally Invasive Surgery for Soft Tissue Management: Aesthetics, Postoperative Morbidity, and Clinical Results

Diversity in endodontic Enterococcus faecalis from Brazil with high occurrence of ST 397 clone

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