Antimicrobial resistance in swine production

Aarestrup, Frank Møller; Duran, Clara; Burch, David

doi:10.1017/s1466252308001503

Cited by 131 publications

(98 citation statements)

References 35 publications

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“…The same situation was found in Denmark, where H. parasuis isolates were fully susceptible to β-lactams (Aarestrup et al 2008). Using breakpoints for amoxicillin (Schwarz et al 2010), high level and very high level of resistance to ampicillin have been found in the United Kingdom (21.1 %) and Spain (66.7 %), respectively after reevaluation of published results by De la Fuente et al (2007).…”

Section: Discussionmentioning

confidence: 58%

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Antimicrobial susceptibility of Pasteurella multocida and Haemophilus parasuis isolates associated with porcine pneumonia

Nedbalcová

Kučerová

2013

Acta Vet. Brno

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Pasteurella multocida and Haemophilus parasuis pig isolates obtained in the Czech Republic were tested for their susceptibility against selected antimicrobial agents by broth microdilution method between 2008 and 2011. A low degree of resistance was observed for ampicillin, amoxicillin/clavulanic acid, ceftiofur, tulathromycin, tilmicosin, florfenicol and enrofloxacin in 20 (6.0%), 15 (4.5 %), 2 (0.6%), 8 (2.4%), 13 (3.9%), 5 (1.5%) and 5 (1.5%) P. multocida isolates as well as for tiamulin, gentamicin, tulathromycin, tilmicosin and ampicillin in 2 (2.4%), 2 (2.4%), 3 (3.6%), 3 (3.6%) and 6 (7.2%) H. parasuis isolates. In addition, moderate level of resistance to tiamulin was found in 60 (18.1%) P. multocida isolates and high level of resistance for tetracycline was detected in 107 (32.2 %) P. multocida isolates and in 23 (27.7 %) H. parasuis isolates. Differences between resistance rates of P. multocida and H. parasuis were significant (P ≤ 0.5) only for tiamulin. These data confirmed that antimicrobial resistance is not very widespread among current porcine P. multocida and H. parasuis isolates in the Czech Republic. Antimicrobial resistance, minimal inhibition concentration, respiratory diseases, pigsPasteurella multocida and Haemophilus parasuis are the causative agents of infectious diseases of porcine respiratory tract which cause major economic losses by their negative impact on the weight gain, feed conversion, and health status (Oliveira and Pijoan 2004;Shin et al. 2005). Antibiotic treatment is one of the commonly used measures for the control of pasteurellosis and H. parasuis infections but the use of antimicrobial agents leads to both selection and increase of resistance (Schwarz and Chaslus-Dancla 2001). Failure to treat infectious disease caused by resistant bacteria leads to increased morbidity and mortality (Kolar et al. 2010). Variations in the antimicrobial use for the control of bacterial pathogens in pigs from one country to another can contribute to evident differences in antimicrobial susceptibility of P. multocida and H. parasuis. In accordance with the recommendation of Schwarz et al. (2010) on the requirement of application of the same methodology and interpretive criteria (which would allow for re-evaluation of the original data if the interpretive criteria change over time), only a limited number of recent studies were conducted regarding the susceptibility of P. multocida and H. parasuis to antimicrobials with the use of microdilution method.Considering the lack of recent studies of antimicrobial susceptibility testing of P. multocida and H. parasuis within the European territory, the aim of this work was to examine a panel of various isolates obtained from different Czech locations to determine their susceptibility to selected antimicrobial agents by the broth microdilution method, in accordance with the guidelines issued by the Clinical and Laboratory Standards Institute (CLSI) in 2008. Materials and Methods SamplingAll P. multocida and H. parasuis isolates were obtained fro...

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Section: Discussionmentioning

confidence: 58%

“…According to available data, florfenicol exhibited an excellent activity against H. parasuis isolates, regardless of their geographic origin (De la Fuente et al 2007;Aarestrup et al 2008). Therefore, florfenicol remains useful for the treatment of H. parasuis infections.…”

Section: Discussionmentioning

confidence: 99%

Antimicrobial susceptibility of Pasteurella multocida and Haemophilus parasuis isolates associated with porcine pneumonia

Nedbalcová

Kučerová

2013

Acta Vet. Brno

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“…Continuous monitoring of antimicrobial resistance and responsible usage of drugs in livestock are very important in protecting against bacterial pathogens (23). Classes of antimicrobials such as cephalosporins and fluoroquinolones are relevant for human health and their use in livestock production should be limited or avoided as far as possible (1). Furthermore, antimicrobial usage in animals increases the possibility of acquiring resistance determinates in target bacteria as well as in commensal and zoonotic bacteria (2).…”

Section: Methodsmentioning

confidence: 99%

Antimicrobial susceptibility of Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples in Serbia

Žutić¹,

Pavlovic²,

Radanović³

et al. 2016

Medycyna Weterynaryjna

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SummaryPorcine pleuropneumonia, caused by Actinobacillus pleuropneumoniae is one of the most important bacterial diseases of the pig respiratory tract. One hundred and forty eight Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples were tested for their susceptibility to 11 antimicrobials by disk diffusion method. Isolates were obtained from the pathoanatomically altered pig's lung that died with signs of respiratory disease. Antimicrobial discs with following concentration were used: ampicillin 10 µg, amoxicillin 10 µg, amoxicillin/clavulanic acid 20/10 µg, cefotaxime 30 µg, gentamicin 10 µg, penicillin 10 IU, streptomycin 10 µg, tetracycline 30 µg, enrofloxacin 5 µg, lincospectin 15/200 µg, florfenicol 30 µg and trimethoprim/sulfamethoxazole 1.25/23.75 µg. Isolated strains showed various susceptibility to tested antimicrobials. Seventy-five percent of isolates were resistant to one or more drugs frequently used in the treatment of pig's diseases at farms in Serbia. All 148 isolates were susceptible to cefotaxime, enrofloxacin and florfenicol, while 96% of them were susceptible to amoxicillin/clavulanic acid and lincospectin. Susceptibility of isolates to amoxicillin, gentamicin and trimethoprim/sulfamethoxazole were 91%, 77% and 64%, respectively. The highest resistance rates were determined for tetracycline and streptomycin, 34% and 31%, respectively. When compared to our previous results, we noticed a decrease in resistance to tetracyclines and trimethoprim/sulfamethoxazole. Our results indicate that A. pleuropneumoniae strains isolated from pig's clinical samples in Serbia show high susceptibility to antimicrobial agents which are most often used in the pig industry.

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“…The heavy reliance on mechanistically similar drugs, to which resistance in other organisms has been shown to develop by a common mechanism, highlights the potential impact of resistance emergence and the clinical value of laboratorytest-guided therapeutic selection. Although there is no consensus method for determining the antimicrobial susceptibility of Brachyspira, trends of decreasing susceptibility among B. hyodysenteriae for the macrolides and pleuromutilins have been described in Europe and the United States (Lobová et al 2004;Aarestrup et al 2008;Prášek et al 2014;Rugna et al 2015;Mirajkar et al 2016a). …”

Section: Treatmentmentioning

confidence: 99%

A review of the current state of antimicrobial susceptibility test methods forBrachyspira

Kulathunga

Rubin

2017

Can. J. Microbiol.

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Abstract:The re-emergence of swine dysentery (Brachyspira-associated muco-haemorrhagic colitis) since the late 2000s has illuminated diagnostic challenges associated with this genus. The methods used to detect, identify, and characterize Brachyspira from clinical samples have not been standardized, and laboratories frequently rely heavily on in-house techniques. Particularly concerning is the lack of standardized methods for determining and interpreting the antimicrobial susceptibility of Brachyspira spp. The integration of laboratory data into a treatment plan is a critical component of prudent antimicrobial usage. Therefore, the lack of standardized methods is an important limitation to the evidence-based use of antimicrobials. This review will focus on describing the methodological limitations and inconsistencies between current susceptibility testing schemes employed for Brachyspira, provide an overview of what we do know about the susceptibility of these organisms, and suggest future directions to improve and standardize diagnostic strategies.Key words: Brachyspira, susceptibility test, method standardization, veterinary diagnostics, swine dysentery.Résumé : La réémergence de la dysenterie porcine (colite muco-hémorragique associée à Brachyspira) depuis la fin des années 2000 a mis en lumière les défis diagnostiques associés à ce genre. Les méthodes utilisées pour détecter, identifier et caractériser Brachyspira à partir d'échantillons cliniques n'ont jamais été standardisées et les laboratoires dépendent fréquemment et fortement de méthodes maison. L'absence de méthodes standardisées pour déterminer et interpréter la susceptibilité antimicrobienne de Brachyspira spp. est particulièrement inquiétante. L'intégration de données expérimentales à un plan de traitement est une composante importante de l'utilisation avisée d'antimicrobiens, et l'absence de méthodes standardisées constitue conséquemment une limite importante à l'utilisation d'antimicrobiens fondée sur des données probantes. Cette synthèse se concentrera sur la description des limites méthodologiques et des incohérences actuelles qui existent entre les programmes de tests utilisés pour Brachyspira, fournira un exposé général de ce que les auteurs connaissent de la susceptibilité de ces organismes et suggérera des orientations afin d'améliorer et standardiser les stratégies diagnostiques. [Traduit par la Rédaction] Mots-clés : Brachyspira, test de susceptibilité, standardisation de méthodes, diagnostics vétérinaires, dysenterie porcine.

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Antimicrobial resistance in swine production

Cited by 131 publications

References 35 publications

Antimicrobial susceptibility of Pasteurella multocida and Haemophilus parasuis isolates associated with porcine pneumonia

Antimicrobial susceptibility of Pasteurella multocida and Haemophilus parasuis isolates associated with porcine pneumonia

Antimicrobial susceptibility of Actinobacillus pleuropneumoniae strains isolated from pig's clinical samples in Serbia

A review of the current state of antimicrobial susceptibility test methods forBrachyspira

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