Antimicrobial Resistance in the Environment

Waseem, Hassan; Williams, Maggie R.; Jameel, Sana; Hashsham, Syed A.

doi:10.2175/106143018x15289915807056

Cited by 13 publications

(7 citation statements)

References 32 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Antibiotic resistance is one of the biggest public health challenges in every country over the world [1,2]. The economic costs, due to clinical interventions and productivity losses, account for 9 billion EUR and 20 billion USD in Europe and the USA, respectively.…”

Section: Introductionmentioning

confidence: 99%

Occurrence of Antibiotic Resistance in the Mediterranean Sea

et al. 2022

View full text Add to dashboard Cite

Seawater could be considered a reservoir of antibiotic-resistant bacteria and antibiotic resistance genes. In this communication, we evaluated the presence of bacterial strains in seawater collected from different coasts of Sicily by combining microbiological and molecular methods. Specifically, we isolated viable bacteria that were tested for their antibiotic resistance profile and detected both antibiotic and heavy metal resistance genes. Both antibiotic-resistant Gram-negative bacteria, Vibrio and Aeromonas, and specific antibiotic resistance genes were found in the seawater samples. Alarming levels of resistance were determined towards cefazolin, streptomycin, amoxicillin/clavulanic acid, ceftriaxone, and sulfamethoxazole/trimethoprim, and mainly genes conferring resistance to β-lactamic and sulfonamide antibiotics were detected. This survey, on the one hand, presents a picture of the actual situation, showing the pollution status of the Tyrrhenian coast of Sicily, and, on the other hand, can be considered as a baseline to be used as a reference time for future analysis.

show abstract

Section: Introductionmentioning

confidence: 99%

Occurrence of Antibiotic Resistance in the Mediterranean Sea

et al. 2022

View full text Add to dashboard Cite

show abstract

“…(CPK) isolates in clinical settings are increasingly being reported [ 12 , 13 ]. Several studies including Waseem et al [ 14 ] have reported CPK and ARGs in non-clinical environments, Proia et al [ 15 ] (2018); Khan et al [ 16 ] in wastewater treatment plants (WWTPs), Uyaguari et al [ 17 ], in agricultural samples and Stange et al [ 18 ] in rivers and lakes. However, none of these studies investigated at the same time the occurrence of relevant carbapenem-resistance genes (CRGs) in isolates recovered from environmental samples.…”

Section: Introductionmentioning

confidence: 99%

Detection of Carbapenem-Resistance Genes in Klebsiella Species Recovered from Selected Environmental Niches in the Eastern Cape Province, South Africa

Ebomah

Okoh

2020

Antibiotics

View full text Add to dashboard Cite

Carbapenemase-producing Enterobacteriaceae (CPE) have been heavily linked to hospital acquired infections (HAI) thereby leading to futility of antibiotics in treating infections and this have complicated public health problems. There is little knowledge about carbapenemase-producing Klebsiella spp. (CPK) in South Africa. This study aimed at determining the occurrence of CPK in different samples collected from selected environmental niches (hospitals, wastewater treatment plants, rivers, farms) in three district municipalities located in the Eastern Cape Province, South Africa. Molecular identification and characterization of the presumptive isolates were determined using polymerase chain reaction (PCR) and isolates that exhibited phenotypic carbapenem resistance were further screened for the possibility of harbouring antimicrobial resistance genes. One hundred (43%) of the 234 confirmed Klebsiella spp. isolates harboured carbapenem-resistance genes; 10 isolates harboured blaOXA-48-like; 17 harboured blaKPC; and 73 isolates harboured blaNDM-1. The emergence of blaKPC, blaOXA-48-like, and blaNDM-1 carbapenem-resistance genes in Klebsiella species associated with environmental sources is of great concern to public health.

show abstract

“…The occurrence of MDR organisms, resistance genes, and antibiotic residues in surface water bodies is well established outside Bangladesh, among similar settings in Asia (O'Flaherty and Cummins, 2017;Qiao et al, 2018;Waseem et al, 2018;Zhang et al, 2019;Singh et al, 2019;Reddy and Dubey, 2019;Ahammad et al, 2014). Natural flow of untreated wastewater into surface water bodies including rivers, lakes or canals is commonly observed in many LMICs and is likely a key driver of environmental transmission of clinically important antibiotic resistant organisms (Rabbani et al, 2017;Karkman et al, 2017;Islam et al, 2017).…”

Section: Discussionmentioning

confidence: 99%