Sexually transmitted infections (STIs) are caused by a wide spectrum of bacteria, viruses and parasites. These agents can be easily transmitted by direct genital or oral sexual contact. Recently, the World Health Organization (WHO), reported that more than 1 million STIs are acquired every day worldwide. Each year, there are an estimated 357 million new infections with one of the following four STIs: chlamydia, gonorrhea, syphilis and trichomoniasis. There are few studies and official reports published on the prevalence of STIs in most Arab countries. However, a few recent studies showed indicate an increased prevalence of certain STIs in some Arab countries, and few data is available on their antimicrobial susceptibility.