Antimicrobial resistance of Shigella sonnei in Korea during the last two decades^Note

Abstract

Eighty-eight strains of Shigella sonnei isolated in Korea during the period 1980 to 1999 were tested for susceptibility to 13 antimicrobial agents. S. sonnei isolates demonstrated high frequencies of resistance to sulfamethoxazole (97.7%), tetracycline (96.6%), and trimethoprim (95.5%). S. sonnei isolates from the 1990s were more resistant to nalidixic acid than isolates from the 1980s (100 vs 7.7%), while isolates from the 1990s were more susceptible to chloramphenicol than isolates from the 1980s (0 vs 100%). Ampicillin-resistant S. sonnei isolates produced the TEM-1 beta-lactamase with a pI of 5.4. The TEM-1 gene was located on conjugally transferable plasmids in the majority of isolates. S. sonnei isolates were all susceptible to cefotaxime, cefoxitin, ceftazidime, ciprofloxacin, and norfloxacin. These results indicate that cephalosporins and quinolones may be alternative antibiotics for the treatment of S. sonnei infections in Korea.

Frequency and antimicrobial susceptibility of Shigella species isolated in Children Medical Center Hospital, Tehran, Iran, 2001-2006

“…1,22,23,27,28 In our study, S. fl exneri was more multiresistant than other species, which is very important due to its frequency. Ceftriaxone and ciprofl oxacin have been shown to be highly effective for shigellosis.…”

“…5,[17][18][19][20][21] In our study Shigella species were sensitive to aminoglycosides, except kanamycin. Kanamycin is a member of aminoglycosides, which resistance to it was reported before by Lee et al (2001) and Jeong et al (2003). 22,23 They had reported the emergence of kanamycin-resistant S. sonnei isolates in Korea.…”

“…Kanamycin is a member of aminoglycosides, which resistance to it was reported before by Lee et al (2001) and Jeong et al (2003). 22,23 They had reported the emergence of kanamycin-resistant S. sonnei isolates in Korea. 1 Although resistance to fl uoroquinolones has been rarely reported, nearly all Shigella isolates are susceptible to these agents.…”

Frequency of serovars and antimicrobial resistance in Shigella spp. from Brazil

“…Multiple resistant strains have oc-curred in Europe (Maraki et al 1998), Africa (Egah et al 2003), Asia (Lee et al 2001), and South America (Fulla et al 2005). In the United States, the most common resistance rates among 620 Shigella isolates (86% of which were S. sonnei) were to ampicillin (77%), streptomycin (54%), trimethoprim-sulfamethoxazole (37%), sulfamethoxazole (32%), and tetracycline (31%) (CDC 2004).…”

Changes in Patterns of Antimicrobial Susceptibility and Integron Carriage among Shigella sonnei Isolates from Southwestern Korea during Epidemic Periods

“…Ampicillin or trimethoprim combined with sulfamethoxazole has been used to treat shigellosis during the last 2 decades. However, a high proportion of S. sonnei isolates from Korea were resistant to these antimicrobial agents (2,4). Integrons are known to be a novel mechanism for dissemination of resistance genes among gram-negative bacteria (1).…”