Antimicrobial resistance patterns of Pseudomonas aeruginosa isolated from canine clinical cases at a veterinary academic hospital in South Africa

Abstract

Although Pseudomonas aeruginosa (P. aeruginosa) can infect both animals and humans, there is a paucity of veterinary studies on antimicrobial resistance of P. aeruginosa in South Africa. Secondary data of canine clinical cases presented at the hospital from January 2007 to December 2013 was used. The following information was recorded: type of sample, the date of sampling and the antimicrobial susceptibility results. Frequencies, proportions and their 95% confidence intervals were calculated for all the categorical variables. In total, 155 P. aeruginosa isolates were identified and included in this study. All the isolates were resistant to at least one antimicrobial (AMR), while 92% were multi-drug resistant (MDR). Most isolates were resistant to lincomycin (98%), penicillin-G (96%), orbifloxacin (90%), trimethoprim-sulfamethoxazole (90%) and doxycycline (87%). A low proportion of isolates was resistant to imipenem (6%), tobramycin (12%), amikacin (16%) and gentamicin (18%). A high proportion of MDR-P. aeruginosa isolates was resistant to amoxycillin-clavulanic acid (99%), tylosin (99%), chloramphenicol (97%) and doxycycline (96%). Few (6%) of MDR-P. aeruginosa isolates were resistant to imipenem. Pseudomonas aeruginosa was associated with infections of various organ systems in this study. All P. aeruginosa isolates of P. aeruginosa exhibited resistance to β-lactams, fluoroquinolones and lincosamides. Clinicians at the hospital in question should consider these findings when treating infections associated with P. aeruginosa.

Otitis eksternalı köpeklerden izole edilen Pseudomonas aeruginosa suşlarının antibiyotik direnç profilleri

“…In this study, MDR prevalence (39.53%) of P. aeruginosa strains was found to be similar to the MDR prevalence of the studies reported by Dos Santos In these studies, sulphonamide, tetracycline, fluoroquinolone and aminoglycoside group antibiotics, which are known to exhibit intrinsic resistance in P. aeruginosa, were found at high levels in MDR profile combinations (Turkyilmaz 2008;Eliasi et al 2020). In addition, the ability of P. aeruginosa to develop acquired resistance also contributes to the formation of MDR (Pang et al 2019).…”

Cultivation of bacterial pathogens and antimicrobial resistance in canine periapical tooth abscesses

“…The findings of this study indicated that Pseudomonas was highly penicillin-resistant; likewise, Eliasi et al (2020) reported that it was highly resistant to amoxicillin-clavulanic acid (92.0%). Interestingly, the results of our study indicated that Pseudomonas could lead to imipenem resistance, which is consistent with the findings of Eliasi et al (2020). Additionally, Klebsiella species were found to be resistant Vet Integr Sci Vet Integr Sci Chawnan et al Vet Integr Sci.…”

“…The bata-lactamase intrinsic resistance pathway of Pseudomonas has arisen as a result of low membrane permeability and AmpC beta-lactamase production (Pechère and Köhler, 1999). The findings of this study indicated that Pseudomonas was highly penicillin-resistant; likewise, Eliasi et al (2020) reported that it was highly resistant to amoxicillin-clavulanic acid (92.0%). Interestingly, the results of our study indicated that Pseudomonas could lead to imipenem resistance, which is consistent with the findings of Eliasi et al (2020).…”

Antibacterial Potential by Rupture Membrane and Antioxidant Capacity of Purified Phenolic Fractions of Persea americana Leaf Extract

“…In this sense, P. aeruginosa and S. choleraesuis show the lowest susceptibility to non-fractioned extract because their growth was inhibited at concentrations above 1400 µg/mL. Additionally, the formation of compact biofilm could conferrer them a major resistance that protects them from the antibacterial properties of the extract [ 38 , 39 ].…”