Antimicrobial resistance, society and environment: A glocal syndemic

Ferrinho, Paulo; Viveiros, Miguel; Fronteira, Inês

doi:10.1016/j.onehlt.2023.100512

Cited by 8 publications

(6 citation statements)

References 16 publications

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“…To solve this problem there we need to nd alternatives to reduce the pressure on current antibiotics on these environments. 55,56 As part of the response to this situation, here we analyzed the antimicrobial effect of 1, 2, 3 and 4 against Gram-negative (Escherichia coli) and Gram-positive (Staphylococcus aureus) by exposing two bacterial cultures to a glass surface covered with each compound for 24 hours. All tested compounds show strong antibacterial effects against E. coli and S. aureus whereas the antibacterial effect on E. coli was slightly higher for each sample and the growth rate of the same microorganisms on the mentioned surface was considerably low.…”

Section: Antibacterial Studiesmentioning

confidence: 99%

Lysine-based non-cytotoxic ultrashort self-assembling peptides with antimicrobial activity

Özbek,

Vilarrocha,

Jover

et al. 2024

RSC Adv.

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Section: Antibacterial Studiesmentioning

confidence: 99%

Lysine-based non-cytotoxic ultrashort self-assembling peptides with antimicrobial activity

Özbek,

Vilarrocha,

Jover

et al. 2024

RSC Adv.

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“…A multidisciplinary panel of experts has proposed guidelines for structuring and reporting full-scale AMR and antimicrobial consumption/antimicrobial residue surveillance data across the three sectors. 44,45 A scoping review has been initiated to identify and synthesize knowledge on mathematical and statistical models of AMR among bacteria in animals, humans, and environmental compartments. 46 Meanwhile, the usage of biodiversity data for research into disease dynamics, particularly for emerging infectious diseases, has not been fully leveraged, although it is consistently contributing to disease ecology research.…”

Section: Holis Tic and Inter Dis Cip Lin Ary Approache S To Safeg Uar...mentioning

confidence: 99%

“…The One Health approach is essential to address the complex problem of antimicrobial resistance (AMR). A multidisciplinary panel of experts has proposed guidelines for structuring and reporting full‐scale AMR and antimicrobial consumption/antimicrobial residue surveillance data across the three sectors 44,45 . A scoping review has been initiated to identify and synthesize knowledge on mathematical and statistical models of AMR among bacteria in animals, humans, and environmental compartments 46 .…”

Section: Holistic and Interdisciplinary Approaches To Safeguard Healthmentioning

confidence: 99%

The One Health approach for allergic diseases and asthma

Jutel

Mosnaim

Bernstein

et al. 2023

Allergy

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The One Health approach is a collaborative and interdisciplinary strategy with focal point on human, animal, and environmental health interconnections. One Health can support the advanced management of allergic diseases and asthma, as complex, multifactorial diseases driven by interactions between the resilience response to the exposome. According to the One Health concept allergic diseases and asthma arising from exposures to a wide range of allergens, infectious agents and irritants (such as pollutants) occurring indoors and outdoors can be heavily influenced by environmental health (air, water, and soil quality) intermingled with animal health. These are currently heavily impacted by climate change, land use, urbanization, migration, overpopulation, and many more. Thus, a coordinated response to address the underlying factors that contribute to the development of allergic diseases and asthma needs to focus on the environment, human, and animal health altogether. Collaborative efforts across multiple sectors, including public health, veterinary medicine, environmental science, and community engagement are thus needed. A wide range of activities, including monitoring and surveillance of environmental and health data, targeted interventions to reduce exposures to allergens and irritants, and research on the underlying mechanisms that drive the development of allergic diseases and asthma are needed to move the field forward. In this consensus document elaborated by the European Academy of Allergy and Clinical Immunology (EAACI) and American Academy of Allergy, Asthma, and Immunology (AAAAI) under the practical allergy (PRACTALL) series, we provide insights into the One Heath approach aiming to provide a framework for addressing the complex and multifactorial nature of allergic diseases and asthma.

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“…In the past decades, the rapid evolution of drug-resistant bacteria has become a global challenge due to the abuse of antibiotics. − Particularly, Gram-positive (G+) drug-resistant bacteria, such as methicillin-resistant Staphylococcus aureus (MRSA) and vancomycin-resistant Enterococcus (VRE), have captured much attention. − Presently, MRSA and VRE are two major causes of nosocomial infections, while the available drugs for treating them are limited . Thus, selective inhibition of G+ bacteria is of significance in practice. , Fortunately, compared with the cell wall structure of Gram-negative (G−) bacteria, the G+ bacterial cell walls do not contain an outer membrane composed of lipids, proteins, and lipopolysaccharides, making them more susceptible to antibiotics or other antibacterial agents. − Meanwhile, bacteria prefer to use d -amino acids in the biosynthesis of the peptidoglycan cell wall, while mammalian cells exclusively uptake l -amino acids. − This property reveals the feasibility of d -amino acids for the selective killing of G+ bacteria. − …”

Section: Introductionmentioning

confidence: 99%

Chiral Sulfur Nanosheets for Dual-Selective Inhibition of Gram-Positive Bacteria

Huang

Zhang

et al. 2023

ACS Nano

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Elemental sulfur is the oldest known antimicrobial agent. However, conventional sulfur in the clinic suffers from poor aqueous solubility and limited antibacterial activity, greatly hindering its practical use. Herein, we report a reform strategy coupling dimension engineering with chirality transfer to convert conventional 3D sulfur particles into chiral 2D sulfur nanosheets (S-NSs), which exhibit 50-fold improvement of antibacterial capability and dualselective inhibition against Gram-positive bacteria. Benefiting from the inherent selectivity of S-NSs and chirality selectivity from decorated Dhistidine, the obtained chiral S-NSs are proven to precisely kill Gram-positive drug-resistant bacteria, while no obvious bacterial inhibition is observed for Gram-negative bacteria. Mechanism studies reveal that S-NSs produce numerous reactive oxygen specipoes and hydrogen sulfide after incubation with bacteria, thus causing bacterial membrane destruction, respiratory chain damage, and ATP production inhibition. Upon spraying chiral S-NSs dispersions onto MRSA-infected wounds, the skin healing process was greatly accelerated in 8 days due to metabolism inhibition and oxidative damage of bacteria, indicating the excellent treatment efficiency of MRSA-infected wounds. This work converts the traditional well-known sulfur into modern antibacterial agents with a superior Gram-selectivity bactericidal capability.

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Antimicrobial resistance, society and environment: A glocal syndemic

Cited by 8 publications

References 16 publications

Lysine-based non-cytotoxic ultrashort self-assembling peptides with antimicrobial activity

Lysine-based non-cytotoxic ultrashort self-assembling peptides with antimicrobial activity

The One Health approach for allergic diseases and asthma

Chiral Sulfur Nanosheets for Dual-Selective Inhibition of Gram-Positive Bacteria

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