Antimicrobial Resistance: We Must Pursue a Collaborative, Global Approach and Use a “One Health” Approach

Lonsdale, Derrick; Lipman, Jeffrey

doi:10.3390/antibiotics8040237

Cited by 2 publications

(2 citation statements)

References 19 publications

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“…The type and dosage of antibiotic is usually decided by the clinician taking into account the available knowledge, though previous experiences are also considered ( 1 , 4 ). However, antibiotic prescription also may be affected by patient expectations and beliefs ( 5 - 9 ).…”

Section: Introductionmentioning

confidence: 99%

Patient perception about the need for antibiotics after tooth extractions: A cross-sectional study

Pérez-Amate¹,

Figueiredo²,

Cortés-Peral³

et al. 2021

J Clin Exp Dent

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Section: Introductionmentioning

confidence: 99%

Patient perception about the need for antibiotics after tooth extractions: A cross-sectional study

Pérez-Amate¹,

Figueiredo²,

Cortés-Peral³

et al. 2021

J Clin Exp Dent

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“…Optimization of antimicrobial therapy requires the selection of appropriate treatment that must be administered as quickly as possible 1 . This is particularly challenging in the hospital setting, where antimicrobial resistance (AMR) is a major barrier to effective treatment selection 2 .…”

Section: Introductionmentioning

confidence: 99%

A nested cohort 5-year Canadian surveillance of Gram-negative antimicrobial resistance for optimized antimicrobial therapy

Blondeau,

Charles,

Loo

et al. 2023

Sci Rep

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We analyzed 5 years (2016–2020) of nested Canadian data from the Study for Monitoring Antimicrobial Resistance Trends (SMART) to identify pathogen predominance and antimicrobial resistance (AMR) patterns of adult Gram-negative infections in Canadian health care and to complement other public surveillance programs and studies in Canada. A total of 6853 isolates were analyzed from medical (44%), surgical (18%), intensive care (22%) and emergency units (15%) and from respiratory tract (36%), intra-abdominal (25%), urinary tract (24%) and bloodstream (15%) infections. Overall, E. coli (36%), P. aeruginosa (18%) and K. pneumoniae (12%) were the most frequent isolates and P. aeruginosa was the most common respiratory pathogen. 18% of Enterobacterales species were ESBL positive. Collective susceptibility profiles showed that P. aeruginosa isolates were highly susceptible (> 95%) to ceftolozane/tazobactam and colistin, though markedly less susceptible (58–74%) to other antimicrobials tested. Multi-drug resistance (MDR) was present in 10% of P. aeruginosa isolates and was more frequent in those from respiratory infections and from ICU than non-ICU locations. Of P. aeruginosa isolates that were resistant to combinations of ceftazidime, piperacillin/tazobactam and meropenem, 73–96% were susceptible to ceftolozane/tazobactam over the period of the study. These national data can now be combined with clinical prediction rules and genomic data to enable expert antimicrobial stewardship applications and guide treatment policies to optimize adult patient care.

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Antimicrobial Resistance: We Must Pursue a Collaborative, Global Approach and Use a “One Health” Approach

Abstract: Treating infection is a key part of the work of most clinicians. Whilst new drug technologies like biologics have begun a revolution in the treatment of cancer and autoimmune disease, there has been a conspicuous absence of new classes of antibiotic over the last 30 years. [...]

Cited by 2 publications

References 19 publications

Patient perception about the need for antibiotics after tooth extractions: A cross-sectional study

Patient perception about the need for antibiotics after tooth extractions: A cross-sectional study

A nested cohort 5-year Canadian surveillance of Gram-negative antimicrobial resistance for optimized antimicrobial therapy

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