Antimicrobial-resistant bacteria in the community setting

Furuya, E. Yoko; Lowy, Franklin D.

doi:10.1038/nrmicro1325

Cited by 301 publications

(200 citation statements)

References 131 publications

Supporting

Mentioning

192

Contrasting

Unclassified

Order By: Relevance

“…The exact mechanism underlying our finding, though remains to be elucidated, may represent an example of the so-called 'collateral damage,' a term referring to the ecological adverse effects of antibiotic therapy, 71 which is believed to be driven largely by antibiotic selection pressure, and promoted by the spreading of plasmid-mediated antimicrobial-resistant genes within the progeny strains or unrelated resistant strains. 72,73 As mentioned earlier, fluoroquinolone is one of the most common agents linked to this collateral damage, that is, the emergence of various kinds of pathogens. [21][22][23][24][25][27][28][29][30][31][32][33][34][35][36][37][38]71 However, the patterns of emergence vary among studies; no single study has demonstrated the impact of fluoroquinolone use on all of the specific antibiotic-resistant patterns.…”

Section: Discussionmentioning

confidence: 99%

Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Liu

Lai

Huang

et al. 2010

Bone Marrow Transplant

View full text Add to dashboard Cite

This study aimed to determine the impact of blood stream infections (BSIs) on outcome of allogeneic hematopoietic SCT (HSCT), and to examine the influence of old (nonlevofloxacin-containing) and new (levofloxacin-based) prophylactic antibiotic protocols on the pattern of BSIs. We retrospectively enrolled 246 allogeneic HSCT recipients between January 1999 and June 2006, dividing patients into BSI (within 6 months post-HSCT, n ¼ 61) and non-BSI groups (n ¼ 185). We found that Gramnegative bacteria (GNB) predominated BSI pathogens (54%). Multivariate analyses showed that patients with a BSI, compared with those without, had a significantly greater 6-month mortality (hazard ratio, 1.75; 95% confidence interval, 1.09-2.82; P ¼ 0.021) and a significantly increased length of hospital (LOH) stay (70.8 vs 55.2 days, P ¼ 0.014). Moreover, recipients of old and new protocols did not have a significantly different 6-month mortality and time-to-occurrence of BSIs. However, there were significantly more resistant GNB to third-generation cephalosporins and carbapenem in recipients of levofloxacin-based prophylaxis. Our data suggest that BSIs occur substantially and impact negatively on the outcome and LOH stay after allogeneic HSCT despite antibiotic prophylaxis. Levofloxacin-based prophylaxis, albeit providing similar efficacy to non-levofloxacin-containing regimens, may be associated with increased antimicrobial resistance.

show abstract

Section: Discussionmentioning

confidence: 99%

Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Liu

Lai

Huang

et al. 2010

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…For instance, Klebsiella pneumonie have become resistant against cephalosporins and carbapenems, Escherichia coli against cephalosporins and fluoroquinolones, and Staphylococcus aureus adapts rapidly to acquire resistance against penicillin, methicillin, tetracycline, and erythromycin. 2 It is clear from the above that there is an ongoing need in developing new antimicrobial agents. In this sense, antimicrobial polymers offer a high versatility for avoiding microbial contaminations or infections.…”

Section: ■ Introductionmentioning

confidence: 99%

Effect of glycounits on the antimicrobial properties and toxicity behavior of polymers based on quaternized DMAEMA

et al. 2014

View full text Add to dashboard Cite

show abstract

“…4, 6, 7, and 17). The rapid evolution of drug resistance among bacterial pathogens is today a major clinical problem (23,24), and the reports on slow drug resistance evolution are important in that they suggest a combination of efflux pump inhibitory drugs and growth inhibitory drugs as a future strategy for effective treatment of bacterial disease with minimal risk of target resistance development (6). One reason for the slowing down of target resistance emergence by drug efflux pump deficiency may simply be the greatly enhanced drug susceptibility that arises by drug efflux inhibition (6).…”

Section: Target Resistance Masking and The Evolution Of Drug Resistancementioning

confidence: 99%

Drug efflux pump deficiency and drug target resistance masking in growing bacteria

Fange

Nilsson²,

Tenson³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

View full text Add to dashboard Cite

Recent experiments have shown that drug efflux pump deficiency not only increases the susceptibility of pathogens to antibiotics, but also seems to ''mask'' the effects of mutations, that decrease the affinities of drugs to their intracellular targets, on the growth rates of drug-exposed bacteria. That is, in the presence of drugs, the growth rates of drug-exposed WT and target mutated strains are the same in a drug efflux pump deficient background, but the mutants grow faster than WT in a drug efflux pump proficient background. Here, we explain the mechanism of target resistance masking and show that it occurs in response to drug efflux pump inhibition among pathogens with high-affinity drug binding targets, low cell-membrane drug-permeability and insignificant intracellular drug degradation. We demonstrate that target resistance masking is fundamentally linked to growth-bistability, i.e., the existence of 2 different steady state growth rates for one and the same drug concentration in the growth medium. We speculate that target resistance masking provides a hitherto unknown mechanism for slowing down the evolution of target resistance among pathogens.antibiotic resistance ͉ efflux pump inhibition ͉ macrolides

show abstract

Antimicrobial-resistant bacteria in the community setting

Cited by 301 publications

References 131 publications

Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Impact of bloodstream infections on outcome and the influence of prophylactic oral antibiotic regimens in allogeneic hematopoietic SCT recipients

Effect of glycounits on the antimicrobial properties and toxicity behavior of polymers based on quaternized DMAEMA

Drug efflux pump deficiency and drug target resistance masking in growing bacteria

Contact Info

Product

Resources

About