Antimicrobial-resistant foodborne pathogens in the Middle East: a systematic review

Alsayeqh, Abdullah F.; Baz, Amany Hassan Attia; Darwish, Wageh Sobhy

doi:10.1007/s11356-021-17070-9

Cited by 10 publications

(16 citation statements)

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“…e absence of L. monocytogenes in the examined yoghurt samples might be attributed to the antimicrobial activities of some compounds secreted by lactic acid bacteria present in yoghurt [34]. e abuse of antimicrobials during animal farming and livestock production might lead to the development of antimicrobial resistance [12,41]. e achieved results in this study revealed that 100% of the recovered L. monocytogenes isolates showed resistance against streptomycin and erythromycin, while more than 70% of the isolates showed resistance against oxytetracycline, nalidixic acid, sulfamethoxazole, cephalothin, and amikacin.…”

Section: Discussionmentioning

confidence: 99%

Prevalence of Multidrug-Resistant Listeria monocytogenes in Dairy Products with Reduction Trials Using Rosmarinic Acid, Ascorbic Acid, Clove, and Thyme Essential Oils

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Elabbasy

Mohamed

et al. 2022

Journal of Food Quality

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Continuous monitoring of Listeria spp., particularly Listeria monocytogenes, in foods is a mandatory task for food safety and microbiology sectors. This study aimed to determine the prevalence and antimicrobial resistance patterns of L. monocytogenes in milk and dairy products retailed in Egypt. Furthermore, an experimental trial was conducted to investigate the antilisterial effects of some phytochemicals. A total of 200 samples (market raw milk, Kareish cheese, Damietta cheese, and plain yoghurt, 50 each) were collected and examined for detection of Listeria spp. The results revealed that 8, 12, 1, and 0 samples of market raw milk, Damietta cheese, Kareish cheese, and plain yoghurt were contaminated with Listeria spp., respectively. Antimicrobial sensitivity testing revealed that all L. monocytogenes isolates (15) were resistant to streptomycin and erythromycin. Molecular analysis revealed that 86.67% of L. monocytogenes harbored hylA virulent gene. Use of rosmarinic acid, ascorbic acid, thyme, and clove essential oils significantly ( P < 0.05 ) reduced L. monocytogenes growth in soft cheese—artificially contaminated with L. monocytogenes throughout a 4-week incubation period. In conclusion, strict hygienic conditions should be adopted during the preparation and distribution of dairy products. In addition, rosmarinic acid, ascorbic acid, clove, and thyme essential oils are good candidates as food preservatives with antilisterial activities.

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Section: Discussionmentioning

confidence: 99%

Prevalence of Multidrug-Resistant Listeria monocytogenes in Dairy Products with Reduction Trials Using Rosmarinic Acid, Ascorbic Acid, Clove, and Thyme Essential Oils

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Elabbasy

Mohamed

et al. 2022

Journal of Food Quality

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“…Antimicrobial resistance (AMR) is a major public health concern mainly resulting from the use and misuse of antimicrobial agents. AMR occurs when bacteria, fungi, parasites, and viruses change over time and are no longer susceptible to medicines, making infections difficult to treat and increasing the risk of spreading the infection, intensifying the severity of the disease, and raising death rates [15,16]. After the bacteria has acquired resistance, AMR disseminates by clonal spreads of the bacteria and horizontal gene transfer (HGT), that is, by integrons or plasmids, leading to the accumulation of antimicrobial resistance genes (ARGs) in pathogenic and non-pathogenic bacteria within an individual organism [16].…”

Section: Introductionmentioning

confidence: 99%

“…After the bacteria has acquired resistance, AMR disseminates by clonal spreads of the bacteria and horizontal gene transfer (HGT), that is, by integrons or plasmids, leading to the accumulation of antimicrobial resistance genes (ARGs) in pathogenic and non-pathogenic bacteria within an individual organism [16]. Rising antimicrobial use contributes to the sharing of resistant bacteria and resistance genes between food animals and humans through the food production chain [15]. AMR in Campylobacter spp.…”

Section: Introductionmentioning

confidence: 99%

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Systematic Review and Meta-Analysis of Integrated Studies on Salmonella and Campylobacter Prevalence, Serovar, and Phenotyping and Genetic of Antimicrobial Resistance in the Middle East—A One Health Perspective

et al. 2022

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Background:Campylobacter and Salmonella are the leading causes of foodborne diseases worldwide. Recently, antimicrobial resistance (AMR) has become one of the most critical challenges for public health and food safety. To investigate and detect infections commonly transmitted from animals, food, and the environment to humans, a surveillance–response system integrating human and animal health, the environment, and food production components (iSRS), called a One Health approach, would be optimal. Objective: We aimed to identify existing integrated One Health studies on foodborne illnesses in the Middle East and to determine the prevalence, serovars, and antimicrobial resistance phenotypes and genotypes of Salmonella and Campylobacter strains among humans and food-producing animals. Methods: The databases Web of Science, Scopus, and PubMed were searched for literature published from January 2010 until September 2021. Studies meeting inclusion criteria were included and assessed for risk of bias. To assess the temporal and spatial relationship between resistant strains from humans and animals, a statistical random-effects model meta-analysis was performed. Results: 41 out of 1610 studies that investigated Campylobacter and non-typhoid Salmonella (NTS) in the Middle East were included. The NTS prevalence rates among human and food-producing animals were 9% and 13%, respectively. The Campylobacter prevalence rates were 22% in humans and 30% in food-producing animals. The most-reported NTS serovars were Salmonella Enteritidis and Salmonella Typhimurium, while Campylobacter jejuni and Campylobacter coli were the most prevalent species of Campylobacter. NTS isolates were highly resistant to erythromycin, amoxicillin, tetracycline, and ampicillin. C. jejuni isolates showed high resistance against amoxicillin, trimethoprim–sulfamethoxazole, nalidixic acid, azithromycin, chloramphenicol, ampicillin, tetracycline, and ciprofloxacin. The most prevalent Antimicrobial Resistance Genes (ARGs) in isolates from humans included tetO (85%), Class 1 Integrons (81%), blaOXA-61 (53%), and cmeB (51%), whereas in food-producing animals, the genes were tetO (77%), Class 1 integrons (69%), blaOXA-61 (35%), and cmeB (35%). The One Health approach was not rigorously applied in the Middle East countries. Furthermore, there was an uneven distribution in the reported data between the countries. Conclusion: More studies using a simultaneous approach targeting human, animal health, the environment, and food production components along with a solid epidemiological study design are needed to better understand the drivers for the emergence and spread of foodborne pathogens and AMR in the Middle East.

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“…Pathogenic bacteria in foods of animal origin may exhibit antibiotic resistance patterns that can be transmitted through foods. This phenomenon is of great concern, especially since antibiotic-resistant pathogenic bacteria are increasingly found in foods, including those of animal origin (Gourama, 2020 ; Alsayeqh et al ., 2021 ).…”

Section: Introductionmentioning

confidence: 99%

Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region

et al. 2022

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The aim of the present study was to investigate the resistome and virulome diversity of 43 isolates of Listeria monocytogenes, Salmonella enterica and S. aureus collected from artisanal fermented meat and dairy products and their production environments in Portugal, Spain, Italy and Morocco. After DNA extraction, genomes were sequenced, and de novo assembled. Genetic relationships among genomes were investigated by SNP calling and in silico 7- loci MLST. Genomes of the same species belonged to different ST-types demonstrating the circulation of different clones in in the same artisanal production plant. One specific clone included genomes of S. Paratyphi B belonging to ST43 and repeatedly isolated for more than a year in an artisanal sausage production plant. No genomes but three (belonging to Salmonella enterica), were predicted as multiresistant to different antimicrobials classes. Regarding virulence, genomes of L. monocytogenes belonging to ST1, ST3 and ST489, as well as genomes of S.enterica enterica (ST43, ST33, ST314, ST3667, ST1818, ST198) and ST121 S. aureus were predicted as virulent and hypervirulent. The occurrence of virulent and hypervirulent L. monocytogenes, Salmonella enterica and S. aureus strains in artisanal fermented meat and dairy productions as well as in their finished products suggests the need for a specific focus on prevention and control measures able to reduce the risk of these biological hazards in artisanal food productions.

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Antimicrobial-resistant foodborne pathogens in the Middle East: a systematic review

Cited by 10 publications

References 218 publications

Prevalence of Multidrug-Resistant Listeria monocytogenes in Dairy Products with Reduction Trials Using Rosmarinic Acid, Ascorbic Acid, Clove, and Thyme Essential Oils

Prevalence of Multidrug-Resistant Listeria monocytogenes in Dairy Products with Reduction Trials Using Rosmarinic Acid, Ascorbic Acid, Clove, and Thyme Essential Oils

Systematic Review and Meta-Analysis of Integrated Studies on Salmonella and Campylobacter Prevalence, Serovar, and Phenotyping and Genetic of Antimicrobial Resistance in the Middle East—A One Health Perspective

Resistome and virulome diversity of foodborne pathogens isolated from artisanal food production chain of animal origin in the Mediterranean region

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