Antimicrobial Screening of Cotinus Coggyggria Scop Leaves Extract for Its Application in Endodontics

Abstract

For the new Millennium our knowledge of persistent bacteria, disinfecting agents and safety concerns has greatly increased and to achieve predictable, complete disinfection of the root canal system with minimal side-effects, there is no doubt that more innovative basic and biological approach is needed. In this sense, the search of alternative natural preparations for the disinfection of root canals remains relevant. The aim of our research was determination the antimicrobial activity of Cotinus coggygria leaves extract water solutions against Enterococcus faecalis. Microbiological study was conducted at the Laboratory of General Microbiology of Bacteriophage Analytical Diagnostic Center. The In vitro studies seems encouraging as 2% extract was found to be most effective against Streptococcus spp., while extract 10% solutions were observed to be most effective against Enterococcus faecalis. Pronounced antibacterial activity suggests successful application of Cotinus coggygria Scop extract solutions in Endodontic Practice. The in vivo study is in progress for recommending this novel herbal preparation as an alternative antimicrobial endodontic irrigating solution.

​Comparative safety study of the phenolic constituents of smokebush (Cotinus coggygria) leaves

“…The wound-healing and antibacterial properties of flavonoids are explained by their interactions with dermal collagen fibers and tannin-induced precipitation of bacterial proteins, respectively. 2,3 Pentagalloyl glucose (1,2,3,4,6-penta-O-galloyl-β-Dglucopyranose), the ester of glucose with five moieties of gallic acid, has been one of the first tannins identified from the plant. 4 Due to the numerous phenolic hydroxy groups in its structure, pentagalloyl glucose exhibits antioxidant, antiinflammatory, anti-bacterial, anti-diabetic, and anti-cancer activity.…”