Antimicrobial stewardship in Latin America: Past, present, and future

Fabre, Valeria; Cosgrove, Sara E.; Secaira, Clara; Torrez, Juan Carlos Tapia; Lessa, Fernanda C.; Patel, Twisha S; Quirós, Rodolfo

doi:10.1017/ash.2022.47

Cited by 16 publications

(20 citation statements)

References 34 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Reports of AS programs and activities in the pediatric population in LA are scarce, and most of the publications related to antibiotic stewardship programs come from the adult population [23,31,50,51]. It is possible that the lack of economic resources with no research infrastructure in Latin American health systems makes the process of reporting and publishing data regarding this topic difficult with some information, such as personal communications or information in non-indexed journals [52].…”

Section: Antibiotic Stewardship In Latin Americamentioning

confidence: 99%

Regional Perspective of Antimicrobial Stewardship Programs in Latin American Pediatric Emergency Departments

Yock‐Corrales

Naranjo-Zuñiga

2023

Antibiotics

View full text Add to dashboard Cite

Antibiotic stewardship (AS) programs have become a priority for health authorities to reduce the number of infections by super-resistant microorganisms. The need for these initiatives to minimize the inadequate use of antimicrobials is essential, and the election of the antibiotic in the emergency department usually impacts the choice of treatment if the patients need hospital admission, becoming an opportunity for antibiotic stewardship. In the pediatric population, broad-spectrum antibiotics are more likely to be overprescribed without any evidence-based management, and most of the publications have focused on the prescription of antibiotics in ambulatory settings. Antibiotic stewardship efforts in pediatric emergency departments in Latin American settings are limited. The lack of literature on AS programs in the pediatric emergency departments in Latin America (LA) limits the information available. The aim of this review was to give a regional perspective on how pediatric emergency departments in LA are working towards antimicrobial stewardship.

show abstract

Section: Antibiotic Stewardship In Latin Americamentioning

confidence: 99%

Regional Perspective of Antimicrobial Stewardship Programs in Latin American Pediatric Emergency Departments

Yock‐Corrales

Naranjo-Zuñiga

2023

Antibiotics

View full text Add to dashboard Cite

show abstract

“…Infection rates of VRSA have been shown to mirror those of VRE and VISA. Higher burdens of VRSA disease in lower- and middle-income continents of Africa and Asia have been attributed to poorer hygiene, reduced implementation of antimicrobial stewardship and limitations in epidemiological surveillance [ 279 , 280 , 281 , 282 , 283 , 284 , 285 , 398 ]. There have been no reports of VRSA in Oceania [ 398 , 466 ].…”

Section: Vancomycinmentioning

confidence: 99%

“…One explanation for this is the comparatively higher fitness cost of VISA and VRSA lineages [ 463 , 468 ]. The global distribution of VRSA and VISA in agriculture is unknown, but presumably highest in developing nations due to their high quantity of antimicrobial consumption, high prevalence of intensive farming and lower levels of hygiene, antimicrobial stewardship and surveillance [ 279 , 280 , 281 , 282 , 283 , 284 , 285 , 289 , 398 , 476 , 477 ].…”

Section: Vancomycinmentioning

confidence: 99%

“…In developed European nations with robust stewardship and surveillance programs [ 275 , 276 ], the prevalence of VRE is much lower than in other developed countries with comparatively modest levels of stewardship such as Australia [ 277 , 278 ]. The observation that lower and middle-income countries in Africa, Asia and South America can have comparable or lower prevalence of VRE to some developed nations such as Australia, despite their absence of quality stewardship and surveillance programs however can be explained by the lack of published epidemiological data from these regions [ 279 , 280 , 281 , 282 , 283 , 284 , 285 ]. Therefore, it is likely that the true burden of VRE in Africa, Asia and South America are much higher than the available figures provided from those countries.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Vancomycin Resistance in Enterococcus and Staphylococcus aureus

Walker

Oliveira

2022

Microorganisms

View full text Add to dashboard Cite

Enterococcus faecalis, Enterococcus faecium and Staphylococcus aureus are both common commensals and major opportunistic human pathogens. In recent decades, these bacteria have acquired broad resistance to several major classes of antibiotics, including commonly employed glycopeptides. Exemplified by resistance to vancomycin, glycopeptide resistance is mediated through intrinsic gene mutations, and/or transferrable van resistance gene cassette-carrying mobile genetic elements. Here, this review will discuss the epidemiology of vancomycin-resistant Enterococcus and S. aureus in healthcare, community, and agricultural settings, explore vancomycin resistance in the context of van and non-van mediated resistance development and provide insights into alternative therapeutic approaches aimed at treating drug-resistant Enterococcus and S. aureus infections.

show abstract

“…Important advances have been made in AMS strategies and antimicrobial stewardship programs (ASP), particularly in high-income countries (HICs) [ 6 , 7 , 8 ]. Nevertheless, little data are available from low- and middle-income countries (LMIC) [ 2 , 9 , 10 ].…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Stewardship Programs in Latin America and the Caribbean: A Story of Perseverance, Challenges, and Goals

Restrepo-Arbeláez,

Garcia-Betancur,

Pallares

et al. 2023

Antibiotics

View full text Add to dashboard Cite

Antimicrobial resistance is one of the major global health threats. Antimicrobial stewardship (AMS) has been set as a priority within international action plans to combat this issue. The region of Latin America and the Caribbean are recognized for their high antimicrobial resistance rates; nevertheless, a low number of studies describing implemented interventions for this topic have been published. This review aims to provide an overview of the status of AMS in our region, focusing on the main progress achieved and describing the different published efforts made by countries towards the implementation of antimicrobial stewardship programs (ASP). Common areas of intervention included were (a) education approaches, (b) antimicrobial guideline implementation and monitoring, (c) diagnostic stewardship, (d) technological tools: electronic clinical decision support systems in AMS, (e) pharmacy-driven protocols and collaborative practice agreements, and (f) economic impact. The search demonstrated the varied interventions implemented in diverse healthcare settings; the results accentuate their influence on antimicrobial consumption, antimicrobial resistance, clinical outcomes, and direct economic impact. The integration of multiple strategies within each hospital was highlighted as an essential key to ASP success. Even though the literature found demonstrated clear progress, there is still a special need for strengthening leadership from the top down, defining goals based on needs, and gaining support through policy and financing in LAC.

show abstract

Antimicrobial stewardship in Latin America: Past, present, and future

Cited by 16 publications

References 34 publications

Regional Perspective of Antimicrobial Stewardship Programs in Latin American Pediatric Emergency Departments

Regional Perspective of Antimicrobial Stewardship Programs in Latin American Pediatric Emergency Departments

Vancomycin Resistance in Enterococcus and Staphylococcus aureus

Antimicrobial Stewardship Programs in Latin America and the Caribbean: A Story of Perseverance, Challenges, and Goals

Contact Info

Product

Resources

About