2020
DOI: 10.1016/j.ajic.2019.12.023
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Antimicrobial stewardship program achieved marked decrease in Clostridium difficile infections in a Veterans Hospital

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Cited by 5 publications
(8 citation statements)
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“…Our study found that the ASP was associated with a reduction in HO-CDI incidence, which was consistent with previous reports in geriatric settings [3,9]. However, ASPs that target only high-cost, broad-spectrum antimicrobials can miss opportunities to reduce HO-CDI due to the overuse of unaudited low-cost and often unnecessary antimicrobials [10].…”
Section: Discussionsupporting
confidence: 91%
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“…Our study found that the ASP was associated with a reduction in HO-CDI incidence, which was consistent with previous reports in geriatric settings [3,9]. However, ASPs that target only high-cost, broad-spectrum antimicrobials can miss opportunities to reduce HO-CDI due to the overuse of unaudited low-cost and often unnecessary antimicrobials [10].…”
Section: Discussionsupporting
confidence: 91%
“…Consequently, patients receiving antibiotics during acute care (AGU) are at high risk of HO-CDI in the weeks following acute care, i.e., during their stay in GRU. Other studies have reported a strong association between HO-CDI and antibiotic consumption [3][4][5][6][7][8], and other ASPs have been successful in decreasing HO-CDI incidence in geriatric hospitals [3,9]. Despite the constant reduction in antibiotic consumption in the AGU, HO-CDI in the GRU increased again in 2018.…”
Section: Discussionmentioning
confidence: 96%
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“…By 2017, 76% of acute-care hospitals reported meeting the CDC Core Stewardship Elements, compared to 41% in 2014. 31,32 Several investigators have reported an association of antibiotic stewardship programs with decreased hospital-onset CDI, [33][34][35] which may explain the decrease we and others have noted in HCA-CDI in recent years. In contrast, antibiotic stewardship b All comparisons of incidence rates between commercially insured and Medicaid-insured persons were significant with P < .001, except cystic fibrosis (P = .025) and nephrotic syndrome (P = .002).…”
Section: Discussionmentioning
confidence: 85%
“…By 2017, 76% of acute-care hospitals reported meeting the CDC Core Stewardship Elements, compared to 41% in 2014. 31,32 Several investigators have reported an association of antibiotic stewardship programs with decreased hospital-onset CDI, 3335 which may explain the decrease we and others have noted in HCA-CDI in recent years. In contrast, antibiotic stewardship programs have gained much less traction in the outpatient setting, 36,37 despite the facts that most antibiotics are prescribed in ambulatory settings and an estimated 30%–50% of these antibiotic prescriptions are considered inappropriate.…”
Section: Discussionmentioning
confidence: 88%