Antimicrobial Strategies in Novel Drug Delivery Systems

Bueno, Juan; Demirci, Fatih; Başer, K. Hüsnü Can

doi:10.1016/b978-0-12-811079-9.00016-1

Cited by 11 publications

(7 citation statements)

References 93 publications

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“…Skin/tissue infections are defined as damage caused by pathogens, with variable resistance and severity [ 56 ]. The most characteristic feature of wound infections is their ability to form a biofilm, which affects the healing process by reducing the efficacy of antibiotics and inducing resistance of the microorganisms to treatment [ 57 ].…”

Section: Resultsmentioning

confidence: 99%

Synergistic Antimicrobial Activity of Magnetite and Vancomycin-Loaded Mesoporous Silica Embedded in Alginate Films

Dolete

Ilie

Chircov

et al. 2023

Gels

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The aim of the present study was to obtain a hydrogel-based film as a carrier for the sustained and controlled release of vancomycin, an antibiotic commonly used in various types of infections. Considering the high-water solubility of vancomycin (>50 mg/mL) and the aqueous medium underlying the exudates, a prolonged release of vancomycin from an MCM-41 carrier was sought. The present work focused on the synthesis of malic acid coated magnetite (Fe3O4/malic) by co-precipitation, synthesis of MCM-41 by a sol-gel method and loading of MCM-41 with vancomycin, and their use in alginate films for wound dressing. The nanoparticles obtained were physically mixed and embedded in the alginate gel. Prior to incorporation, the nanoparticles were characterized by XRD, FT-IR and FT-Raman spectroscopy, TGA-DSC and DLS. The films were prepared by a simple casting method and were further cross-linked and examined for possible heterogeneities by means of FT-IR microscopy and SEM. The degree of swelling and the water vapor transmission rate were determined, considering their potential use as wound dressings. The obtained films show morpho-structural homogeneity, sustained release over 48 h and a strong synergistic enhancement of the antimicrobial activity as a consequence of the hybrid nature of these films. The antimicrobial efficacy was tested against S. aureus, two strains of E. faecalis (including vancomycin-resistant Enterococcus, VRE) and C. albicans. The incorporation of magnetite was also considered as an external triggering component in case the films were used as a magneto-responsive smart dressing to stimulate vancomycin diffusion.

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Section: Resultsmentioning

confidence: 99%

Synergistic Antimicrobial Activity of Magnetite and Vancomycin-Loaded Mesoporous Silica Embedded in Alginate Films

Dolete

Ilie

Chircov

et al. 2023

Gels

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“…As we mentioned, antimicrobial peptides are an up-and-coming alternative for the treatment of infections caused by multidrug-resistant bacteria; however, they present some disadvantages such as their reliability due to their susceptibility to proteases and changes in pH, short half-life, and rapid renal clearance [ 227 ]. Therefore, it is possible to use AMPs in combination with drug delivery systems, such as liposome encapsulation, inorganic (AuNPs or AgNPs), and polymeric (chitosan, or PLGA) nanoparticles [ 228 ].…”

Section: New Therapeutic Strategies: Combinatorial Treatmentsmentioning

confidence: 99%

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

et al. 2022

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Since the discovery of antibiotics, humanity has been able to cope with the battle against bacterial infections. However, the inappropriate use of antibiotics, the lack of innovation in therapeutic agents, and other factors have allowed the emergence of new bacterial strains resistant to multiple antibiotic treatments, causing a crisis in the health sector. Furthermore, the World Health Organization has listed a series of pathogens (ESKAPE group) that have acquired new and varied resistance to different antibiotics families. Therefore, the scientific community has prioritized designing and developing novel treatments to combat these ESKAPE pathogens and other emergent multidrug-resistant bacteria. One of the solutions is the use of combinatorial therapies. Combinatorial therapies seek to enhance the effects of individual treatments at lower doses, bringing the advantage of being, in most cases, much less harmful to patients. Among the new developments in combinatorial therapies, nanomaterials have gained significant interest. Some of the most promising nanotherapeutics include polymers, inorganic nanoparticles, and antimicrobial peptides due to their bactericidal and nanocarrier properties. Therefore, this review focuses on discussing the state-of-the-art of the most significant advances and concludes with a perspective on the future developments of nanotherapeutic combinatorial treatments that target bacterial infections.

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“…Hydrogels facilitate an intrinsic hydrated environment which allows the damaged tissue to regenerate by aiding autolytic debridement [ 7 , 8 ]. The dressings offer a temporary barrier against superficial infections, speeding up the healing process [ 9 ]. An effective dressing for treating wounds must exhibit the following features: excellent biocompatibility, adequate swelling behavior to maintain the wound’s moist environment, good mechanical properties in the wet state and cell adhesion capacity [ 10 , 11 ].…”

Section: Introductionmentioning

confidence: 99%

Novel Nanocomposite Hydrogels Based on Crosslinked Microbial Polysaccharide as Potential Bioactive Wound Dressings

Marin

Kaya

et al. 2023

Materials

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A multitude of dressings have been developed to promote wound repair, such as membranes, foams, hydrocolloids and hydrogels. In this study, a crosslinked polysaccharide hydrogel was mixed with a bioactive ingredient to synthesize a novel nanocomposite material to be used in wound healing. Variation of the ratio between hydrogel components was followed and its effect was analyzed in regard to swelling, degradation rate and thermo-mechanical behavior. The resulting crosslinked structures were characterized by FTIR and microscopy analyses. The antimicrobial activity of the crosslinked hydrogels loaded with bioactive agent was evaluated using two bacterial strains (Gram-positive Staphylococcus aureus and Gram-negative bacteria Escherichia Coli). All the results showed that the new synthesized biopolymer nanocomposites have adequate properties to be used as antibacterial wound dressings.

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Antimicrobial Strategies in Novel Drug Delivery Systems

Cited by 11 publications

References 93 publications

Synergistic Antimicrobial Activity of Magnetite and Vancomycin-Loaded Mesoporous Silica Embedded in Alginate Films

Synergistic Antimicrobial Activity of Magnetite and Vancomycin-Loaded Mesoporous Silica Embedded in Alginate Films

Nanomaterials-Based Combinatorial Therapy as a Strategy to Combat Antibiotic Resistance

Novel Nanocomposite Hydrogels Based on Crosslinked Microbial Polysaccharide as Potential Bioactive Wound Dressings

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