Antimicrobial surface functionalization of plastic catheters by silver nanoparticles

Abstract

A method to coat plastic catheters with bioactive silver nanoparticles was developed. These catheters are non-toxic and are capable of targeted and sustained release of silver at the implantation site. Because of their demonstrated antimicrobial properties, they may be useful in reducing the risk of infectious complications in patients with indwelling catheters.

Nanomedicine opened new horizons for metal nanoparticles to treat multi-drug resistant organisms

“…Metalis nowadays used on medical devices to support anti-biofilm activity. Biofilms from clinical isolates of P. aeruginosa were treated with gum arabic capped-metal nanoparticles (GA-NPs) showing a concentration dependent inhibition of bacterial growth and treatment of catheters with GA-NPs at50 μg/mL resulted in 95% inhibition of bacterial colonization of the plastic catheter surface (88).Other authors have also shown the applications of nanometal as antibiofilms for coating catheters with positive results against both Gram-positive and Gramnegative bacteria (92,94). Furthermore, no significant accumulation of metal was detected in the main organs of the test animals in which engineered catheters had been implanted (92).…”

Silver doped perfluoropolyether-urethane coatings: Antibacterial activity and surface analysis

“…No surface silver was observed on the coating after exposure to PBS. The daily exchange of anionic species such as chlorides and phosphates in the PBS would have depleted the available surface silver, by the possible formation of AgCl and Ag 3 PO 4 precipitates on the coating surface [27]. No visible precipitates were observed in the PBS solutions after silver release.…”

“…The bacterial cells that reside near the substratum are in anoxic regions and are thus slow growing, leading to an intrinsic tolerance to antibiotic dosage -relative to the aerobic cells in the peripheral layers of the biofilm [30]. S. epidermidis is the most common bacterium isolated from medical devices such as vascular catheters, prosthetic implants and intrauterine devices [27]. Several strategies have been investigated in preventing biofilm growth on indwelling biomaterials [31].…”

Degradation of Malachite Green (Dye) by using Photo-Catalytic Biogenic Silver Nanoparticles Synthesized using Red Algae (Gracilaria corticata) Aqueous Extract

“…Among all nanoparticles noble metal nanoparticles have enormous applications in diverse areas such as bioimaging, sensor, diagnosis, and novel therapeutic in biomedical field (Salata, 2004). Metallic silver and silver nanoparticles were recently applied as antimicrobial agents in various products such as cosmetics (Kokura et al, 2010), animal feed (Hojberg et al, 2005), Coating of catheters (Roe et al, 2008), wound dressing (Fernandez et al, 2008), and water purification (Choi et al, 2008) with a minimal risk of toxicity in humans. Nowadays the biological systems were eagerly used for nanoscale material synthesis and assembly is an alternative method of physical and chemical process.…”