Antimicrobial Surgical Sutures: Fabrication and Application of Infection Prevention and Wound Healing

Li, Hongbin; Wang, Zixuan; Robledo-Lara, Juan Antonio; He, Jinmei; Huang, Yudong; Cheng, Feng

doi:10.1007/s12221-021-0026-x

Cited by 9 publications

(3 citation statements)

References 93 publications

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“…In order to provide sutures with favorable antimicrobial, anti-inflammatory and other healingpromoting properties, most of the different coating methods have been employed, including impregnation/impregnation, [91][92][93] layer-by-layer deposition 94 and grafting. 95,96 Viju et al's research team successfully prepared one-dimensional structured silk-protein braided fabrics using the braiding technique and introduced chitosan and tetracycline hydrochloride for antimicrobial treatment by surface modification. 97,98 The final product was a silk-protein-based suture with excellent antimicrobial function.…”

Section: Biomedical Applicationsmentioning

confidence: 99%

Silk-based intelligent fibers and textiles: structures, properties, and applications

Yang,

Wang,

Wang

et al. 2024

Chem. Commun.

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Section: Biomedical Applicationsmentioning

confidence: 99%

Silk-based intelligent fibers and textiles: structures, properties, and applications

Yang,

Wang,

Wang

et al. 2024

Chem. Commun.

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“…достаточно быстро колонизируются микрофлорой, образующей на поверхности изделия биопленку, защищающую их от воздействия как факторов иммунной защиты организма, так и антимикробных препаратов. С учетом этой ситуации целесообразно воздействие на микроорганизмы изнутри, т. е. непосредственно с поверхности имплантата, содержащего соответствующие лекарственные препараты, что позволяет снизить их концентрацию в организме и локализовать воздействие [1][2][3][4][5][6][7][8].…”

Section: Introductionunclassified

Imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization

Zhukovskiy

Khokhlova

Filipenko

et al. 2022

Vestn. Voronež. gos. univ. inž. tehnol.

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The study of the types and properties of surgical threads, as well as the experience in the production of suture surgical material and its use shows that the most promising for surgical practice are threads with antimicrobial properties. Of the methods for fixing medicinal compounds with chemical bonds for suture materials, the most expedient is their attachment by the reaction of ion-exchange interaction. Since polycaproamide (PCA) practically does not contain functional groups, a preliminary modification stage is required to impart ion-exchange properties to PCA fibrous materials. One of these stages of modification is the process of graft polymerization of methacrylic acid (MAA) in order to create active groups on the fiber, for example, peroxide or hydroperoxide. Modification of chemical fibers by graft copolymerization with inogenic monomers is one of the widespread methods of obtaining fibrous ion exchangers. Principles, new approaches and technologies for imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization have been developed. Regularities in the production of fibrous PCA of sorption active materials by chemical initiation by a redox system (Fe2++H2O2) located in a modifying bath, as well as by pre-oxidation of fiber PCA in order to create peroxide and hydroperoxide groups on the fiber, are revealed.

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“…Consequently, levofloxacin (LVFX, C 18 H 20 FN 3 O 4 , ( S )-9-fluoro-2,3-dihydro-3-methyl-10-(4-methylpiperazin-1-yl)-7-oxo-7 H -pyrido[1,2,3-de]-1,4-benzoxazine-6-carboxylic acid) (Figure ) is another choice for use as a replacement for the TC antimicrobial drug to enhance the SSI inhibition. Nonetheless, presently, only a few investigations on the efficiency of LVFX-coated PLC sutures for reducing SSI have been reported. − Therefore, this paper now describes the synthesis, characterization, fiber fabrication and mechanical strength improvement, and LVFX coating of a synthesized medical-grade PLC copolymer for potential use as a long-term absorbable monofilament surgical suture.…”

Section: Introductionmentioning

confidence: 99%

Development of an Antimicrobial-Coated Absorbable Monofilament Suture from a Medical-Grade Poly(l-lactide-co-ε-caprolactone) Copolymer

et al. 2021

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In this study, a medical-grade poly(l-lactide-co-ε-caprolactone) (PLC) copolymer with a monomer ratio of l-lactide (L) to ε-caprolactone (C) of 70:30 mol % for use as an absorbable surgical suture was synthesized via ring-opening polymerization (ROP) using a novel soluble liquid tin(II) n-butoxide (Sn(OnC4H9)2) as an initiator. In fiber fabrication, the process included copolymer melt extrusion with a minimal draw followed by sequential controlled hot-drawing and fixed-annealing steps to obtain oriented semicrystalline fibers with improved mechanical strength. For healing enhancement, the fiber was dip-coated with “levofloxacin” by adding the drug into a solution mixture of acetone, poly(ε-caprolactone) (PCL), and calcium stearate (CaSt) in the ratio of acetone/PCL/CaSt = 100:1% w/v:0.1% w/v. The tensile strength of the coated fiber was found to be increased to ∼400 MPa, which is comparable with that of commercial polydioxanone (PDS II) of a similar size. Finally, the efficiency of the drug-coated fiber regarding its controlled drug release and antimicrobial activity was investigated, and the results showed that the coated fiber was able to release the drug continuously for as long as 30 days. For fiber antimicrobial activity, it was found that a concentration of 1 mg/mL was sufficient to inhibit the growth of Staphylococcus aureus (MRSA), Escherichia coli O157:H7, and Pseudomonas aeruginosa, giving a clear inhibition zone range of 20–24 mm for 90 days. Cytotoxicity testing of the drug-coated fibers showed a %viability of more than 70%, indicating that they were nontoxic.

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Antimicrobial Surgical Sutures: Fabrication and Application of Infection Prevention and Wound Healing

Cited by 9 publications

References 93 publications

Silk-based intelligent fibers and textiles: structures, properties, and applications

Silk-based intelligent fibers and textiles: structures, properties, and applications

Imparting ion-exchange properties to fibrous polycaproamide materials by chemically initiated graft copolymerization

Development of an Antimicrobial-Coated Absorbable Monofilament Suture from a Medical-Grade Poly(l-lactide-co-ε-caprolactone) Copolymer

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