Antimicrobial susceptibilities of anaerobic bacteria isolated from female genital tract infections

Abstract

Certain species or subspecies of anaerobic bacteria are isolated with higher frequency from female genital tract infections than from other anatomic sites. To gain susceptibility data more specific to the treatment of these infections, nine antimicrobial agents were tested by an agar dilution technique against 230 anaerobic bacteria isolated solely from obstetric and gynecological infections. These genital isolates were, in general, very susceptible to imipenem (most active, inhibiting all gram-negative rods at s1 ,ug/ml), clindamycin (all isolates inhibited at s4 ,ug/ml), metronidazole (all gram-negative rods inhibited at s4 ,ug/ml), and chloramphenicol. Penicillin G had generally low activity against Bacteroides spp., not restricted to just the Bacteroides fragilis group, although it was very active against gram-positive species. Bacteroides bivius, a species uniquely common in female genital infections, was particularly resistant (90% MIC, 64 U/ml). Also, the Bacteroides melaninogenicus isolates were less susceptible than previously reported for isolates not

Resistance of Peptostreptococcus spp. to macrolides and lincosamides: inducible and constitutive phenotypes

“…Scattered information on this topic can nevertheless be obtained in publications dealing with the comparative effects of different antimicrobial agents on anaerobic bacteria. Most published work confirms the general susceptibilities of the isolates to erythromycin or clindamycin (5,9,10). However, clindamycin-and/or erythromycin-resistant strains were found in some studies (1,3,15).…”

Beta-lactamase production and susceptibility of US and European anaerobic gram-negative bacilli to beta-lactams and other agents

“…Later studies showed an increase in the frequency of detection of IMactamase producing fusobacteria. In 1983 Aldridge et al However, other recent studies did not find any penicillin-resistant fusobacteria in 31 strains studied (4,8,31). Tuner and her co-workers (17) described a l~-lactamase in Fusobacterium nucleatum in 1985 (17), and in 1987 reported 4 of 40 fusobacteria to be 13-1actamase producers (32).…”

Beta-lactamase production and susceptibilities to amoxicillin, amoxicillin-clavulanate, ticarcillin, ticarcillin-clavulanate, cefoxitin, imipenem, and metronidazole of 320 non-Bacteroides fragilis Bacteroides isolates and 129 fusobacteria from 28 U.S. centers

“…3-lactamase-negative strains was 2 ,ug/ml; that for 3-lactamelaninogenicus (two), B. intermedius (one), F. mortiferum mase-positive strains was 8 ,ug/ml (Tables 3 and 4 (5). Other recent studies did not find any penicillin-resistant fusobacteria in 31 strains studied (7,16,23 ,ug/ml. Our findings confirm previous reports of susceptibility to these agents (3,9,12,18,19,23,30 The results of the current study emphasize significant rates of P-lactamase production in non-B.…”

“…Although the Bacteroides fragilis group comprises the most important group of anaerobic gram-negative pathogens, infections with other Bacteroides species and fusobacteria are increasingly encountered (2,11,16,17,26,28). As the susceptibility patterns of these organism groups has been assumed to be relatively stable, routine susceptibility testing has not been regarded as necessary (24,27,28).…”