Antimicrobial Susceptibility of 471 Enterococcal Strains Responsible for Infections at 101 French Hospitals

Pangon, B.; Pina, P.; Gazagne, Louise; Chauvel, Murielle; Godard, Thierry; Courvalin, Patrice; Allouch, P.

doi:10.1007/s100960050414

Cited by 8 publications

(3 citation statements)

References 6 publications

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“…The distribution of species according to isolation sources, observed in this study, was similar to what was previously found by other authors in different areas (8,18,19,27), with a predominance of isolation of E. faecalis (92.8%) and E. faecium (2.9%), and urine (70.3%) and various secretions (20.7%) as the Urine 310 8 ---1 1 -320 Secretions 83 2 2 5 --2 -94 Blood 11 ------1 12 Catheter 10 -1 -----11 Other 8 3 4 -2 1 --18 Total 422 13 7 5 2 2 3 1 455 most frequent sources of isolation. This is in agreement with literature reports, which point to E. faecalis as the main species involved in human infections, followed by E. faecium (20)(21)(23)(24).…”

Section: Discussionsupporting

confidence: 92%

“…E. faecium strain arouses more attention owing to its unique characteristics of antimicrobial resistance (35), something which was also found in this study. Although the other enterococcal species of physiological groups I and II identified in this study (E. avium, E. casseliflavus, E. gallinarum e E. raffinosus) are less frequently isolated, they have been also reported as etiological agents of infections in humans (10,15,27).…”

Section: Discussionmentioning

confidence: 74%

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Antimicrobial susceptibility among Enterococcus isolates from the city of Porto Alegre, RS, Brazil

d’Azevedo

Dias

Lemos³

et al. 2004

Braz. J. Microbiol.

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Resistance to several classes of antimicrobial agents is a remarkable characteristic of enterococcal strains increasingly reported worldwide. Information about strains isolated in the southern region of Brazil is still limited. In this study, a total of 455 consecutive enterococcal isolates recovered from patients living in Porto Alegre, Brazil, were identified at species level and evaluated for their antimicrobial susceptibilities by agar diffusion testing. The most frequent species was E. faecalis (92.8%), followed by E. faecium (2.9%), E. gallinarum (1.5%), E. avium (1.1%), E. hirae (0.7%), E. casseliflavus (0.4%), E. durans (0.4%), and E. raffinosus (0.2%). According to the results of disk tests 62.0% of the strains were resistant to tetracycline, 42.6% to erythromycin, 24.8% to chloramphenicol, 22.6% to ciprofloxacin, 22.0% to norfloxacin, 3.5% to ampicillin, 3.5% to nitrofurantoin. High level resistance to aminoglycosides was found in 37.8% of the isolates, with 23.5% being resistant to gentamicin, 14.3% to streptomycin, and 2.8% to both gentamicin and streptomycin. No vancomycin resistant or b-lactamase producing isolates were found. The results indicate that a significant percentage of isolates are resistant to different antimicrobials, pointing out the need for control strategies to avoid dissemination of resistant isolates and for continuous surveillance for the detection of emerging resistance traits.

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Section: Discussionsupporting

confidence: 92%

Section: Discussionmentioning

confidence: 74%

Antimicrobial susceptibility among Enterococcus isolates from the city of Porto Alegre, RS, Brazil

d’Azevedo

Dias

Lemos³

et al. 2004

Braz. J. Microbiol.

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“…faecalis was the species more frequently isolated from all clinical samples as reported in previous studies (Murray 1990;Guiney and Urwin 1993;Facklam and Sahm 1995;Pangon et al 1999). The finding that approximately 25% of E. faecalis isolates and over 75% of E. faecium isolates were resistant to penicillin and ampicillin has great importance, since penicillin and ampicillin are the main drugs in the treatment of enterococcal infections (Murray 2000).…”

Section: Discussionsupporting

confidence: 61%

Susceptibility Patterns of Enterococci Causing Infections

Öncü

Punar

Eraksoy

2004

Tohoku J. Exp. Med.

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Enterococci are among the common organisms associated with hospital-acquired infections. We examined in vitro activities of different antibiotics to 103 enterococcal isolates. Minimal inhibitory concentrations (MICs) of penicillin G, ampicillin, gentamicin, ciprofloxacin, ofloxacin, levofloxacin, grepafloxacin, trovafloxacin and gemifloxacin were determined by broth microdilution testing method. Among the isolates 71 (69%) were identified as E. faecalis and 32 (31%) as E. faecium. While over 75% of E. faecium isolates were resistant to penicillin and ampicillin, approximately 25% of E. faecalis isolates were resistant to penicillin and ampicillin. None of the E. faecalis and E. faecium isolates were resistant to vancomycin. While 17 (52%) of E. faecium isolates exhibited high-level gentamicin resistance (HLGR), high level streptomycin resistance (HLSR) was detected in 24 (74%) of the isolates. In contrast, HLGR and HLSR rates for E. faecalis were 14 (20%) and 22 (31%), respectively. Both HLGR and HLSR were detected with higher frequency in ampicillin resistant isolates. Among fluoroquinolones, gemifloxacin and trovafloxacin were the most potent antibiotics tested. There was no increase in MIC 90 values of the fluoroquinolones in ampicillin resistant isolates in comparison with ampicillin susceptible isolates. Our data suggest newer fluoroquinolones would be good alternative agents to use especially for combination drug therapy where enterococci with ampicillin resistance and HLAR are prevalent.enterococci; susceptibility; infection

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