Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia: report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009–2010

Wang, Hui; Chen, Minjun; Xu, Yingchun; Sun, Hongli; Yang, Qiwen; Hu, Yunjian; Cao, Bin; Chu, Yunzhuo; Liu, Yong; Zhang, Rong; Yu, Yunsong; Sun, Ziyong; Zhuo, Chao; Ni, Yizhao; Hu, Bijie; Tan, Thean Yen; Hsueh, Po-Ren; Wang, Jen-Hsien; Ko, Wen Chien; Chen, Yen-Hsu; Wahjono, Hendro

doi:10.1016/j.ijantimicag.2011.06.015

Cited by 41 publications

(27 citation statements)

References 29 publications

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“…While the development of fluoroquinolone resistance has been linked with fluoroquinolone use (181), the rates of resistance in S. pneumoniae remain relatively low (Ͻ1% in the United States and Ͻ3% in Europe) (182), although higher rates have been reported in Asia (10.5%) (183,184) and Canada (7.3%) (185). Resistance to fluoroquinolones can also develop during treatment, and there are several reports describing treatment failures in pneumococcal infections where fluoroquinolones were used (186,187).…”

Section: Fluoroquinolone Resistancementioning

confidence: 99%

Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective

et al. 2016

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SUMMARYStreptococcus pneumoniaeinflicts a huge disease burden as the leading cause of community-acquired pneumonia and meningitis. Soon after mainstream antibiotic usage, multiresistant pneumococcal clones emerged and disseminated worldwide. Resistant clones are generated through adaptation to antibiotic pressures imposed while naturally residing within the human upper respiratory tract. Here, a huge array of related commensal streptococcal strains transfers core genomic and accessory resistance determinants to the highly transformable pneumococcus. β-Lactam resistance is the hallmark of pneumococcal adaptability, requiring multiple independent recombination events that are traceable to nonpneumococcal origins and stably perpetuated in multiresistant clonal complexes. Pneumococcal strains with elevated MICs of β-lactams are most often resistant to additional antibiotics. Basic underlying mechanisms of most pneumococcal resistances have been identified, although new insights that increase our understanding are continually provided. Although all pneumococcal infections can be successfully treated with antibiotics, the available choices are limited for some strains. Invasive pneumococcal disease data compiled during 1998 to 2013 through the population-based Active Bacterial Core surveillance program (U.S. population base of 30,600,000) demonstrate that targeting prevalent capsular serotypes with conjugate vaccines (7-valent and 13-valent vaccines implemented in 2000 and 2010, respectively) is extremely effective in reducing resistant infections. Nonetheless, resistant non-vaccine-serotype clones continue to emerge and expand.

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Section: Fluoroquinolone Resistancementioning

confidence: 99%

Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective

et al. 2016

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“…Pneumonia is a leading cause of death in the elderly worldwide. Streptococcus pneumoniae causes approximately 20-60% of community-acquired pneumonia cases in the United States [2] and approximately 20-22% of cases in Taiwan [3,4]. Invasive pneumococcal diseases (IPD), which include pneumococcal bacteremia, pneumococcal meningitis and pleural empyema, are associated with a higher risk of mortality compared with other pneumococcal diseases.…”

Section: Introductionmentioning

confidence: 99%

The 23-valent pneumococcal polysaccharide vaccine is effective in elderly adults over 75 years old—Taiwan's PPV vaccination program

Tsai

Hsieh

Chang

et al. 2015

Vaccine

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“…Recently, a study from the CommunityAcquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) from 2009 to 2010 reported that 5.8% of M. catarrhalis isolates were resistant to macrolides and that these isolates were only found in mainland China. 36 Further, the exact mechanisms facilitating this resistance is still unknown. In our study, we confirmed the MIC values obtained by Etest using the broth microdilution method.…”

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confidence: 99%

High Prevalence and Molecular Analysis of Macrolide-NonsusceptibleMoraxella catarrhalisIsolated from Nasopharynx of Healthy Children in China

Liu

Zhao

Zhang

et al. 2012

Microbial Drug Resistance

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Three hundred eighty-three isolates of Moraxella catarrhalis were collected from healthy children aged less than 2 years in China and assessed for antimicrobial resistance. We found that 92.2% (n=353) produced a β-lactamase. Nonsusceptibility rates to erythromycin and azithromycin, determined using Clinical Laboratory Standards Institute (CLSI) breakpoints, were 40.3% and 22.5%, respectively; nonsusceptibility rates determined using pharmacokinetics/pharmacodynamics breakpoints, however, were 59% and 60.1%. The minimal inhibitory concentration (MIC)(90) values were >256 μg/ml. Nonsusceptibility rates varied by region from 9.7% in Dongguan to 75.9% in Jinan. Further, concomitant resistance to β-lactam antibiotics was also observed. Pulsed-field gel electrophoresis analysis of 27/37 high-level macrolide-resistant M. catarrhalis isolates showed that closely related pulsotypes dominated, with a total of 11 different pulsotypes being observed. The closely related pulsotypes were observed in isolates originating from all six Chinese cities investigated, possibly as a consequence of the mobility of the Chinese population. Sixteen patterns of 23S rRNA mutations were found among 97 selected isolates using polymerase chain reaction and sequencing, but no known ermA, ermB, mefA, or mefE genes could be detected. Mutations A2982T and A2796T in 23S rRNA were related to high-level macrolide resistance (MICs ranging from 24 to >256 μg/ml), while an A2983T mutation was associated with low-level macrolide resistance (MICs ranging from 0.19 to 16 μg/ml).

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Antimicrobial susceptibility of bacterial pathogens associated with community-acquired respiratory tract infections in Asia: report from the Community-Acquired Respiratory Tract Infection Pathogen Surveillance (CARTIPS) study, 2009–2010

Cited by 41 publications

References 29 publications

Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective

Biological and Epidemiological Features of Antibiotic-Resistant Streptococcus pneumoniae in Pre- and Post-Conjugate Vaccine Eras: a United States Perspective

The 23-valent pneumococcal polysaccharide vaccine is effective in elderly adults over 75 years old—Taiwan's PPV vaccination program

High Prevalence and Molecular Analysis of Macrolide-NonsusceptibleMoraxella catarrhalisIsolated from Nasopharynx of Healthy Children in China

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