Antimicrobial susceptibility of Helicobacter pylori strains isolated from children in Israel

Pastukh, Nina; Peretz, Avi; Brodsky, Diana; Isakovich, Natlya; Azrad, Maya; On, Avi

doi:10.1016/j.jgar.2017.10.004

Cited by 14 publications

(14 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…In Israel, primary resistance of H. pylori to clarithromycin is high (consistently > 20%), and eradication rates even with concomitant therapy remain suboptimal. It follows that esomeprazole should be favored in the context of quadruple therapy in our region [23][24][25].…”

Section: Discussionmentioning

confidence: 99%

Comparative Effect of Proton-Pump Inhibitors on the Success of Triple and Quadruple Therapy for Helicobacter pylori Infection

Boltin

Levi

Gingold‐Belfer

et al. 2020

Dig Dis

View full text Add to dashboard Cite

Introduction: Suppression of gastric acid secretion with proton-pump inhibitors (PPI) is an integral part of the treatment of Helicobacter pylori infection. Esomeprazole has been shown to be superior to other PPIs when used in the context of triple therapy; however, comparative data for PPI efficacy in quadruple therapy are lacking. Current guidelines recommend H. pylori eradication with quadruple therapy in areas with high clarithromycin resistance. Objective: To determine whether esomeprazole is more effective than other PPIs in the context of quadruple therapy for H. pylori eradication. Methods: We retrospectively identified 25-to 60-yearold subjects with a positive 13 C-urea breath test and no prior laboratory or endoscopic test for H. pylori infection. Pharmacy dispensation data were retrieved. Results: A total of 7,896 subjects including 2,856 (36.2%) males, aged 40.4 ± 10.6 years, were identified. Of those, 78.1% received omeprazole, 20.1% received lansoprazole, 1.5% received esomeprazole, and 0.34% received pantoprazole together with antibiotics for H. pylori eradication. Esomeprazole was associated with a greater proportion of successful eradication (85.0 vs. 77.5%, esomeprazole vs. omeprazole, OR 1.64; 95% CI 0.99-2.72; p = 0.05). A nonsignificant trend favored esomeprazole over omeprazole among subjects receiving quadruple therapy (90.0 vs. 82.0%, respectively, OR 1.98; 95% CI 0.68-5.72; p = 0.16). Independent predictors of treatment success included older age and quadruple therapy. Conclusion: Esomeprazole is more beneficial than other PPIs for H. pylori eradication. Studies with larger subgroups are necessary to confirm our findings among subjects receiving quadruple therapy.

show abstract

Section: Discussionmentioning

confidence: 99%

Comparative Effect of Proton-Pump Inhibitors on the Success of Triple and Quadruple Therapy for Helicobacter pylori Infection

Boltin

Levi

Gingold‐Belfer

et al. 2020

Dig Dis

View full text Add to dashboard Cite

show abstract

“…In a Chinese study, the authors investigated levofloxacin resistance in 36 children aged 6‐18 years and found no levofloxacin resistance in any child . On the other hand, the fluoroquinolone resistance has been shown to be 2% in Israel, 3.6% in Spain, and 0% in Australia . A meta‐analysis in Portugal revealed that levofloxacin resistance was not detected in children while ciprofloxacin resistance was detected in 4.5% and 4.6% of the children in two studies .…”

Section: Discussionmentioning

confidence: 99%

Helicobacter pylori resistance to clarithromycin and fluoroquinolones in a pediatric population in Turkey: A cross‐sectional study

2019

View full text Add to dashboard Cite

Background Helicobacter pylori antimicrobial resistance is gradually increasing around the world. However, there are a limited number of studies reporting on this issue in the pediatric population. In this study, we aimed to determine H pylori resistance to clarithromycin and fluoroquinolones in the pediatric patients living in Kırıkkale province that were detected with H pylori in gastric biopsies. Moreover, we also aimed to investigate the concordance between the histopathologic and molecular methods used in the diagnosis of H pylori infection. Materials and Methods Patients aged 2‐18 years who had a history of epigastric pain and/or nausea persisting for longer than 1 month underwent upper gastrointestinal endoscopy. Biopsies were taken from the gastric antral mucosa. In the samples detected with H pylori in the histopathologic examination, the presence of H pylori and H pylori resistance to clarithromycin and fluoroquinolones was investigated using the GenoType HelicoDR test which allows the detection of wild‐type and mutant genes. The strains detected with more than one mutant gene are defined as hetero‐resistant strains. Results The 93 patients that underwent DNA extraction and amplification included 68 (73.1%) girls and 25 (26.9%) boys with a median age of 15 ± 2.62 (range 6‐17) years. The overall concordance for the diagnosis of H pylori infection between histopathology and PCR was 94%, and H pylori resistance to clarithromycin and fluoroquinolones was 27% and 15%, respectively. Conclusions The high H pylori resistance to clarithromycin and fluoroquinolones among the pediatric patients in our region implicates that the antibiotic sensitivity of strains should be studied prior to administration in accordance with the recommendations provided in the guidelines. Moreover, the presence of hetero‐resistant strains in our patients may be a reason for treatment failure.

show abstract

“…pylori culture in 154 children with positive RUT [3]. In another study conducted on children and adolescents, the sensitivity for H. pylori culture was 79.3%, and the specificity was 100% [11].…”

Section: 68%mentioning

confidence: 94%

A Study of the Correlation between Bacterial Culture and Histological Examination in Children with Helicobacter pylori Gastritis

Galoș¹,

Năstase²,

Boboc³

et al. 2019

Histology

View full text Add to dashboard Cite

Helicobacter pylori (H. pylori) is one of the most common chronic bacterial infections in the world, and it is currently estimated that approximately half of the world's population is infected with the bacterium. The correct diagnosis and effective treatment of H. pylori gastric infection are essential in controlling this condition. The available diagnostic methods have advantages and limitations related to factors such as age of patients, technical difficulty level, costs and extensive accessibility in hospitals. The eradication therapy of H. pylori infection is still a challenge for gastroenterologists. One of the main causes of failure in H. pylori eradication is antibiotic resistance. Biopsy cultures are the most widely used methods among the antimicrobial susceptibility tests. In case of a negative culture, H. pylori can be clearly recognised in histological sections. The sensitivity and specificity of histology for the diagnosis depend on clinical settings, density of colonisation and the experience of the histopathologist. A prospective study was performed in order to analyse patients with H. pylori gastric infection with positive histology and positive culture versus positive histology and negative culture.

show abstract

Antimicrobial susceptibility of Helicobacter pylori strains isolated from children in Israel

Cited by 14 publications

References 12 publications

Comparative Effect of Proton-Pump Inhibitors on the Success of Triple and Quadruple Therapy for <b><i>Helicobacter pylori</i></b> Infection

Comparative Effect of Proton-Pump Inhibitors on the Success of Triple and Quadruple Therapy for <b><i>Helicobacter pylori</i></b> Infection

Helicobacter pylori resistance to clarithromycin and fluoroquinolones in a pediatric population in Turkey: A cross‐sectional study

A Study of the Correlation between Bacterial Culture and Histological Examination in Children with Helicobacter pylori Gastritis

Contact Info

Product

Resources

About