Antimicrobial susceptibility pattern of &lt;i&gt;Neisseria gonorrhoeae&lt;/i&gt; isolated from fertile and infertile women

Azizmohammadi, Susan; Azizmohammadi, Sima

doi:10.4314/tjpr.v15i12.17

Cited by 4 publications

(6 citation statements)

References 12 publications

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“…In a previous study conducted in Tehran, the prevalence of NG was 5.2% and 16.9% among fertile and infertile women, respectively. 3 Another report from Qom showed a similar rate (5.7%) to the findings of our study, since the symptomatic patients were also included in that study. 20 Four cases of co-infection were found in this research, indicating that approximately 17% of women with gonorrhea also had chlamydia; accordingly, this may justify the need for co-treatment for these infections.…”

Section: Discussionsupporting

confidence: 89%

“…29 As mentioned above, Azizmohammadi and Azizmohammadi detected gonococci in 16.9% of infertile females in their studied population. 3 Further, infection with CT and NG was significantly related to ectopic pregnancy. The current study provides further evidence of these infections increasing the risk of ectopic pregnancy and infertility in Iran.…”

Section: Discussionmentioning

confidence: 93%

“…1 So far, few studies have examined the prevalence of these STIs in Iran, and of the studies conducted to date, the results have likely been affected by research limitations, such as a low sample numbers and insensitive diagnostic methods. 2,3 Nevertheless, the limited amount of pertinent data to date indicates an average prevalence rate of 12.3% for CT and 0%–5.7% for NG, 4,5 and that the prevalence of TV varies under different epidemiological conditions from 0.4% to 42%. 2…”

Section: Introductionmentioning

confidence: 99%

See 2 more Smart Citations

Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study

et al. 2020

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The present study investigates the prevalence of Chlamydia trachomatis (CT), Neisseria gonorrhoeae (NG), and Trichomonas vaginalis (TV) among women with genitourinary infection and pregnancy-related complications in Tehran. It also evaluates the demographic information, symptoms, and sequelae. Endocervical samples were obtained over a period of eight months from 360 women including 180 symptomatic patients and 180 patients with pregnancy-related complications and infertility. CT, NG, and TV were detected in 10.8%, 6.9%, and 8.3% of all patients, respectively. The prevalence of CT, NG, and TV among women in the symptomatic group was 11.1%, 7.2%, and 13.3%, respectively, and among women with pregnancy-related complications and infertility was 10.6%, 6.7%, and 3.3%, respectively. Associations between chlamydia and ectopic pregnancy ( p = 0.001), and infertility ( p < 0.001) were observed. Abortion ( p = 0.008), infertility ( p = 0.005), and ectopic pregnancy ( p < 0.001) were associated with gonorrhea. Abnormal vaginal discharge ( p = 0.02) and vulvar itching ( p = 0.02) were associated with trichomoniasis. Overall, the prevalence rates of CT, NG, and TV were high in these patient groups. These high prevalences suggest that screening programs are required to reduce the burden of these sexually transmitted infections and their effects on genitourinary symptoms, pregnancy-related complications, and infertility.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 93%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study

et al. 2020

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“…[29] All the isolates were resistant to at least three of the antimicrobial agents used, representing a multi-drug resistance of 100%. The high level of resistance to ampicillin, tetracycline and erythromycin observed in this study has also been reported elsewhere [27,28,[30][31][32]. Erythromycin and tetracycline are the recommended drugs for the treatment of chlamydial infections, [33] and most cases of gonorrheae also present with chlamydial coinfection.…”

Section: Discussionsupporting

confidence: 85%

“…Reports from South Africa indicate that ciprofloxacin is no longer used to treat presumptive gonococcal infections in the country [37]. Additionally, N. gonorrhoeae resistance to ciprofloxacin greater than 50% has been reported in other parts of the world, [27,30,38] suggesting a widespread resistance.…”

Section: Discussionmentioning

confidence: 99%

Prevalence and Antimicrobial Susceptibility Pattern of Neisseria gonorrhoeae in Kumasi, Ghana

Acheampong

Opoku

Adokoh

et al. 2018

JAMB

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Background: In most African countries, including Ghana, treatment of the Neisseria gonorrhoeae infection is based on syndromic management owing to lack of laboratory equipment and resources in primary care facilities where most patients first visit. Aim: The aim of this study was to determine the prevalence of Neisseria gonorrhoeae and evaluate its susceptibility pattern to standard antimicrobials used for empirical treatment of the infection in patients that attended Ellolab Diagnostic Centre at Kumasi from November 2014 to July 2017. Methodology: Four hundred and twenty-seven (427) clinical specimens from suspected patients were cultured on chocolate agar. Positive cultures were tested for resistance against twelve Original Research Article

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Antimicrobial resistance and molecular characteristics of Neisseria gonorrhoea isolates in Ghana

Musah,

Addy,

Dufailu

2024

Access Microbiology

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Introduction. Gonorrhoea is a disease associated with humans and caused by Neisseria gonorrhoea. N. gonorrhoea’s ability to evolve and evade various treatment regimens can lead to untreatable gonorrhoea. In the absence of a viable vaccine and a national database on the antimicrobial resistance (AMR) and molecular characteristics of N. gonorrhoea, and with reliance on a syndromic management regime, continuous national antimicrobial resistance surveillance and molecular characterization of N. gonorrhoea remain imperative. Only two gonococcal studies have described N. gonorrhoea’s molecular characteristics linked to AMR in Ghana. Methods. Secondary N. gonorrhoea isolates (n=4) were collected from two metropolises in Ghana: Tamale in the northern sector (n=1) and Accra in the southern sector (n=3). The isolates were confirmed and characterized using polymerase chain reaction (PCR) targeting the porB and tbpB genes, and the disc diffusion method was used to evaluate AMR. N. gonorrhoea multi-antigen sequence typing (NG-MAST) and porin B (porB) gene sequence analyses were employed to reveal the molecular epidemiology and evolutionary trajectory, respectively. Results. All four isolates showed resistance to at least four of the tested antibiotics. One isolate showed resistance to all seven antibiotics, i.e. ceftriaxone, azithromycin, ciprofloxacin, tetracycline, erythromycin, togamycin and penicillin. NG-MAST typing revealed isolate S3 (MZ313864) as ST211. The locus of S2 (MZ313863) (transferrin-binding protein B; tbpB) was identified as tbpB1844, and its porB locus, as porB6412, with only 4 closely related variants but with 15 nucleotide differences. However, its sequence type does not exist. The porB analysis identified isolate S3 (MZ313864) to be found globally, while S2 (MZ313863) is unique to this study. Discussion. Despite the small number of isolates tested, this study recorded multidrug resistance and previously unknown gonococcal variants based on porB gene. Additionally, the molecular typing schemes revealed a disparity between NG-MAST and the National Center for Biotechnology Information (NCBI) platforms. There is a need for continuous gonococcal AMR and molecular surveillance in Ghana to contribute to the global efforts to describe circulating strains and support proper application of the syndromic management regime to gonorrhoea.

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Antimicrobial susceptibility pattern of <i>Neisseria gonorrhoeae</i> isolated from fertile and infertile women

Cited by 4 publications

References 12 publications

Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study

Chlamydia trachomatis, Neisseria gonorrhoeae, and Trichomonas vaginalis among women with genitourinary infection and pregnancy-related complications in Tehran: A cross-sectional study

Prevalence and Antimicrobial Susceptibility Pattern of Neisseria gonorrhoeae in Kumasi, Ghana

Antimicrobial resistance and molecular characteristics of Neisseria gonorrhoea isolates in Ghana

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