Antimicrobial susceptibility profiles of Mycobacterium abscessus complex isolates from respiratory specimens in Shanghai, China

Guo, Qian; Wei, Jianhao; Zou, Wenda; Li, Qiongxian; Qian, Xueqin; Zhu, Zhaoqin

doi:10.1016/j.jgar.2021.02.024

Cited by 12 publications

(12 citation statements)

References 30 publications

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“…Relative to M. kansasii, MAC has much greater rates of resistance to amikacin, isoniazid, rifampicin, ethambutol, doxycycline, clarithromycin, linezolid, and moxifloxacin [19]. M. abscessus is the most problematic species because of its high rates of resistance to rifamycin, macrolides (including clarithromycin and azithromycin), and other key therapeutic drugs [20,21], potentially due to induced drug resistance or drug resistance caused by mutations [22]. Our results showed that M. abscessus had extremely high resistance to all first-line anti-TB drugs, and was only sensitive to amikacin (74.9%).…”

Section: Discussionmentioning

confidence: 99%

Section: Abundances Of Different Ntm Species In Patients With Ntmpdmentioning

confidence: 99%

“…The 56 other species were M. szulgai (8), M. scrofulaceum (11), M. chelonae (12), M. xenopi (8), M. gordonae (4), M. fortuitum (5), unidentified NTM species ( 6), and M. malmoense (2). The 37 cases of mixed infections were M. tuberculosis with NTM (8), M. abscessus with M. intracellulare (22), M. abscessus with M. avium (4), and M. scrofulaceum with M. intracellulare (3). Among all positive mycobacterial cultures from samples of sputum and BALF, the overall NTM positivity rate increased steadily over time (2014: 9.1%; 2015: 10.9%; 2016: 12.1%; 2017: 13.7%; 2018: 15.5%).…”

Section: Abundances Of Different Ntm Species In Patients With Ntmpdmentioning

confidence: 99%

“…The overall median time of treatment was 19.1 months (95%CI: 18.6, 19.6) in the treatment success group and 23.9 months (95%CI: 23.8, 24.1) in the treatment failure group (Table 2). In treatment success and failure groups, we also compared the median duration of therapy for patients with M. kansasii infections (13.5 months [95%CI: 12.9, 14.0] vs. 22 a p-value corrected using Fisher's exact method when the expectation was below 5, -: no statistical value. MAC: Mycobacterium avium complex.…”

Section: Outcomes and Sputum Culture Conversion Rates Of Isolates Fro...mentioning

confidence: 99%

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Factors Associated with Treatment Outcome in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Large Population-Based Retrospective Cohort Study in Shanghai

et al. 2022

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Infectious diseases caused by nontuberculous mycobacteria (NTM) are increasingly common. This retrospective cohort study examined factors associated with outcomes in patients from Shanghai who had NTM pulmonary disease (NTMPD) from January 2014 to December 2018. The causative bacterial species, drug susceptibility test results, treatment outcomes, sputum culture conversion rate, and risk factors associated with treatment failure were determined. The most common species were Mycobacterium avium complex (MAC) (50%), M. abscessus (28%), and M. kansasii (15%). Over five years, the proportions of M. kansasii and M. abscessus increased, and that of MAC decreased. The treatment success rate was significantly greater for patients infected with M. kansasii (89.9%) than MAC (65.0%, p < 0.001) and M. abscessus (36.1%, p < 0.001). Multivariate analysis indicated the risk factors for treatment failure were pathogenic NTM species (M. abscessus: aOR = 9.355, p < 0.001; MAC: aOR = 2.970, p < 0.001), elevated ESR (>60 mm/h: aOR = 2.658, p < 0.001), receipt of retreatment (aOR = 2.074, p < 0.001), and being middle-aged or elderly (>60 years-old: aOR = 1.739, p = 0.021; 45–60 years-old: aOR = 1.661, p = 0.034). The main bacterial species responsible for NTMPD were MAC, M. abscessus, and M. kansasii. Patients who were infected by M. abscessus or MAC, with elevated ESR, received retreatment, and were middle-aged or elderly had an increased risk of treatment failure.

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Section: Discussionmentioning

confidence: 99%

Section: Abundances Of Different Ntm Species In Patients With Ntmpdmentioning

confidence: 99%

Section: Abundances Of Different Ntm Species In Patients With Ntmpdmentioning

confidence: 99%

Section: Outcomes and Sputum Culture Conversion Rates Of Isolates Fro...mentioning

confidence: 99%

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Factors Associated with Treatment Outcome in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Large Population-Based Retrospective Cohort Study in Shanghai

et al. 2022

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“…Relative to M.kansasii, MAC has much greater rates of resistance to amikacin, isoniazid, rifampicin, ethambutol, doxycycline, clarithromycin, linezolid, and moxi oxacin [18] . M.abscessus is the most problematic species, because of its high rates of resistance to rifamycin, macrolides (including clarithromycin and azithromycin), and other key therapeutic drugs [19,20] , potentially due to induced drug resistance or drug resistance caused by mutations [21] . Our results showed that M.abscessus had an extremely high drug resistance rate to all the rst-line anti-TB drugs, only sensitive to amikacin (74.9%).…”

Section: Discussionmentioning

confidence: 99%

Factors Associated With Treatment Outcome in Patients With Nontuberculous Mycobacterial Pulmonary Disease: a Large Population-based Retrospective Cohort Study in Shanghai

Chen

Hai

et al. 2021

Preprint

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Background: Investigate factors associated with treatment outcome in patients with nontuberculous mycobacterial pulmonary disease (NTMPD). Methods: This retrospective cohort study examined NTMPD patients in Shanghai from January 2014 to December 2018. The distribution and incidence of the different causative species were determined. The outcomes of patients infected with different NTM species were compared. Univariate and multivariate binary logistic regression analyses were used to determine the odds ratios (ORs) and 95% confidence intervals (CIs) for the association of different factors with treatment failure. Results: The most common species were Mycobacterium avium complex (MAC) (50%), M. abscessus (28%), and M. kansasii (15%). Over five years, the proportions of M. kansasii and M. abscessus increased, and that of MAC decreased. The treatment success rate was significantly greater for patients infected with M. kansasii (89.9%) than MAC (65.0%, P<0.001) and M. abscessus (36.1%, P<0.001). Multivariate analysis indicated the risk factors for treatment failure were pathogenic NTM species (M. abscessus: aOR=9.355, P<0.001; MAC: aOR=2.970, P=0.021), having an elevated ESR (>60mm/h: aOR=2.658, P<0.001), receipt of retreatment (aOR=2.074, P<0.001), middle-aged and elderly (>60 years-old: aOR=1.739, P=0.021; 45–60 years-old: aOR=1.661, P=0.034). Conclusions: The main bacterial species responsible for NTMPD infections in Shanghai were MAC, M. abscessus, and M. kansasii. Patients with M. kansasii infections had a higher rate of treatment success. Multiple factors including infection by M. abscessu or MAC, an elevated ESR, receiving retreatment, middle-aged and elderly were associated with treatment failure.

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In vitro antimicrobial activity of doxycycline, minocycline, and tigecycline against Mycobacterium abscessus complex: A meta-analysis study

Zhang,

Dong,

Men

et al. 2024

Diagnostic Microbiology and Infectious Disease

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Antimicrobial susceptibility profiles of Mycobacterium abscessus complex isolates from respiratory specimens in Shanghai, China

Cited by 12 publications

References 30 publications

Factors Associated with Treatment Outcome in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Large Population-Based Retrospective Cohort Study in Shanghai

Factors Associated with Treatment Outcome in Patients with Nontuberculous Mycobacterial Pulmonary Disease: A Large Population-Based Retrospective Cohort Study in Shanghai

Factors Associated With Treatment Outcome in Patients With Nontuberculous Mycobacterial Pulmonary Disease: a Large Population-based Retrospective Cohort Study in Shanghai

In vitro antimicrobial activity of doxycycline, minocycline, and tigecycline against Mycobacterium abscessus complex: A meta-analysis study

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