Antimicrobial susceptibility testing determined by Alfred 60/AST (Alifax®) in a multi-sites lab: performance's evaluation and optimization of workflow

Cupaiolo, Roberto; Cherkaoui, S.; Serrano, Gabriela; Dauby, Nicolás; Georgala, Aspasia; Blumental, Sophie; Maillart, Evelyne; Hites, Maya; Hallin, Marie; Martiny, Delphine

doi:10.1016/j.mimet.2022.106433

Cited by 8 publications

(1 citation statement)

References 21 publications

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“…Over the last few years, many RAST methods performed directly on positive blood culture bottles were developed with the overwhelming objective of reducing turn-around times (TAT). Different reports have highlighted the strengths and weaknesses of each method, with special attention paid to a panel of testable microorganisms and accuracy for detecting various antimicrobial resistance mechanisms ( 1 – 6 ). The value of the RAST has never been more important than it is now, with the large spread of multidrug-resistant (MDR) and extremely drug-resistant (XDR) bacteria among humans, animals, and environmental reservoirs.…”

Section: Introductionmentioning

confidence: 99%

Fully Automated EUCAST Rapid Antimicrobial Susceptibility Testing (RAST) from Positive Blood Cultures: Diagnostic Accuracy and Implementation

et al. 2022

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The objective of this study was to evaluate the accuracy and robustness of a fully automated EUCAST RAST (rapid antimicrobial susceptibility test) directly from positive blood culture and to appreciate its implementation constraints. This study was conducted in two phases: (i) spiked blood culture bottles (BCs) using 779 non-duplicate clinical isolates and (ii) a prospective clinical trial including 534 positive BCs sequentially processed in routine at the Bacteriology Laboratory of Geneva University Hospitals.

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Section: Introductionmentioning

confidence: 99%