Antimicrobial usage and presence of extended-spectrum β-lactamase-producing Enterobacteriaceae in animal-rearing households of selected rural and peri-urban communities

Multi‐drug resistant, biofilm‐producing high‐risk clonal lineage of Klebsiella in companion and household animals

“…Higher prevalence of ESBL-producing Klebsiella in companion animals was associated with therapeutic exposure to the third-generation cephalosporins which the owners could afford (Table S1). Prevalence of ESBL-producing Klebsiella in infected dogs and cats varied between the study locations and antibiotic exposure such as The finding in the present study in companion animals is even higher than the prevalence of ESBL-producing Klebsiella in healthy dogs in France and Nigeria (14%, Poirelet al 2013;Okpara et al 2018).…”

“…The isolates were found sensitive to imipenem-EDTA (100Á0%) and gentamicin (43Á0%; Table 3). Similarly, phenotypical resistance to tetracycline, quinolones and chloramphenicol was observed in Klebsiella strains isolated from companion and household animals (Haenni et al 2011;Poirel et al 2013;Harada et al 2016;Okpara et al 2018). Resistance to tetracycline, doxycycline and quinolone is associated with direct exposure to the antibiotics as the drugs are commonly used in dogs, cats and goats during therapy.…”

“…Similarly, lower prevalence of ESBL‐producing Klebsiella / E. coli was detected in household sheep and goats (8·7–17·7%) in Nigeria which was not correlated with antimicrobial usage (Okpara et al . 2018). Occurrence of ESBL‐producing Klebsiella in household animals in absence of the direct exposure to the third‐generation cephalosporins can be correlated with the exposure to the environmental resistance gene pool.…”

“…2018; Okpara et al . 2018). The CTX‐M‐15‐producing K. pneumoniae (international clone ST15) are associated with nosocomial infection in both human and animal population throughout the world (Haenni et al .…”

Ten-year narrative review on antimicrobial resistance in Singapore

“…ESBLproducing Enterobacteriaceae have been reported in livestock and wildlife. (20,21) Reports of livestock-associated MRSA, which are genetically distinct from human isolates, have steadily increased. (18) This is probably due to the overcrowded conditions of food animals in most commercial farms, along with extensive use of antibiotics as growth promoters, prophylaxis or metaphylaxis.…”