Antimicrobial vs Placebo Prophylaxis in Noncardiac Thoracic Surgery

Truesdale, Richard A.

doi:10.1001/jama.1979.03290380030022

Cited by 31 publications

(8 citation statements)

References 13 publications

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“…To specify this point, an independent physician recorded temperature, expectoration, and data from x-ray films of the chest daily. We think that this infection rate might have been under-evaluated in other studies, and that the authors gave different definitions [2,3,16]. In addition, we have used consensus criteria [11,12] to standardize the diagnosis of pneumonia.…”

Section: Discussionmentioning

confidence: 99%

Antibiotic Prophylaxis in Elective Thoracic Surgery: Cefuroxime versus Cefepime

Turna¹,

Kutlu²,

Özalp³

et al. 2003

Thorac cardiovasc Surg

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Section: Discussionmentioning

confidence: 99%

Antibiotic Prophylaxis in Elective Thoracic Surgery: Cefuroxime versus Cefepime

Turna¹,

Kutlu²,

Özalp³

et al. 2003

Thorac cardiovasc Surg

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“…In the first reported, randomized, controlled trial, Kvale et al [18] found that the use of a 5-day course of antibiotics (cefazolin followed by cephalexin) resulted in a significantly smaller number of postoperative infections after pulmonary resections. In another study, in which prophylactic antibiotics (cefazolin followed by cephalothin) were administered for 48 h, no difference in the incidence of postoperative infections was observed between the drug and the placebo groups [19] . In yet another study in 200 patients undergoing major thoracic surgery, a single dose of cefuroxime 1.5 g did not reduce infections of the wound, pleural space, and urinary tract significantly compared with placebo [7] .…”

Section: Discussionmentioning

confidence: 92%

A Randomized Trial of Antimicrobial Prophylaxis in Patients Undergoing Medical Thoracoscopy (APT)

Dhooria

Sehgal²,

Prasad³

et al. 2017

Respiration

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Background: There is no data on the role of prophylactic antibiotics in patients undergoing medical thoracoscopy. Objective: In this study, we evaluated the efficacy and safety of a single dose of intravenous cefazolin in subjects undergoing medical thoracoscopy. Methods: Subjects undergoing medical thoracoscopy were randomized 1:1 to receive either intravenous cefazolin 2 g (antibiotic group) or intravenous saline (control group). The primary outcome was the incidence of infections (surgical site infections and empyema) in the study groups, while the secondary outcomes were complications related to intravenous antibiotics. Results: Of the 121 subjects screened, 100 (mean age ± SD: 52.2 ± 15.2 years; 38 [38%] women) were randomized to the study groups. The incidence of postprocedural infections was not different between the antibiotic and the control group (4 [8%] vs. 6 [12%], p = 0.28). Surgical site infection occurred in 1 subject (2%) in the antibiotic group and 3 subjects (6%) in the saline group (p = 0.62); empyema occurred in 3 subjects (6%) in each group (p = 1.00). There was no association between age, comorbid illness (diabetes mellitus or chronic kidney disease), study group allocation, type of thoracoscope used, duration of procedure, histological diagnosis (benign or malignant), and the occurrence of infections in the postprocedural period. Conclusion: The use of a single dose of cefazolin prior to medical thoracoscopy was not associated with a reduction in the occurrence of postprocedural infection.

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“…Whether PX is reducing these complications cannot be a nswered by our study. According to Truesdale (14) Frimodt -Moller (4), lives (7), a nd Aznar (1) empyema and pneumonia cannot be reduced significantly. There is no advantage of 3 doses of antibiotic over 1 dose in our study considering all infections.…”

Section: Discussionmentioning

confidence: 99%

Perioperative Antibiotic Prophylaxis in General Thoracic Surgery

Wertzel¹,

Swoboda²,

Joos-Würtemberger³

et al. 1992

Thorac cardiovasc Surg

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A prospective study of the efficacy of ampicillin in combination with sulbactam, a beta-lactamase inhibitor, (A/S) in perioperative prophylaxis was performed. The study consisted of two independent parts performed at the same time. Part I included 60 patients with lobectomies and segmentectomies. Group A (A/S 1 x 3 g "single shot") was compared with group B (A/S 3 x 3 g). Superficial wound infections occurred in 3 patients of group A and in 2 patients of group B. There was no empyema. Bronchitis and pneumonia were found in 10 patients of group A and in 7 patients of group B. Part II examined 25 pneumonectomies receiving A/S 3 x 3 g for 3 days. Concentrations of ampicillin and sulbactam in serum and lung tissue were determined and showed adequate levels to cope with usual bacteria in lung surgery. There was one superficial wound infection, 2 cases of bronchitis, and 2 cases of pneumonia.

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Antimicrobial vs Placebo Prophylaxis in Noncardiac Thoracic Surgery

Cited by 31 publications

References 13 publications

Antibiotic Prophylaxis in Elective Thoracic Surgery: Cefuroxime versus Cefepime

Antibiotic Prophylaxis in Elective Thoracic Surgery: Cefuroxime versus Cefepime

A Randomized Trial of Antimicrobial Prophylaxis in Patients Undergoing Medical Thoracoscopy (APT)

Perioperative Antibiotic Prophylaxis in General Thoracic Surgery

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