Antimicrobial wound dressing film utilizing cellulose nanocrystal as drug delivery system for curcumin

Tong, Woei Yenn; Abdullah, Ahmad Yassin Kamari bin; Rozman, Nur Amiera Syuhada; Wahid, Muhamad Izul Aimin bin; Hossain, Md. Sohrab; Ring, Leong Chean; Lazim, Yusriah; Tan, Wen-Nee

doi:10.1007/s10570-017-1562-9

Cited by 97 publications

(48 citation statements)

References 19 publications

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“…Curcumin accelerated the wound healing by increasing the level of TGF-β1 which is useful for cell growth and proliferation. Curcumin also protects the skin cells from oxidative damages [ 87 ]. Wathoni and co-workers formulated 2-hydroxypropyl-ϒ-cyclodextrin sacran hydrogel films incorporated with curcumin for wound healing application.…”

Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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Some of the currently used wound dressings have interesting features such as excellent porosity, good water-absorbing capacity, moderate water vapor transmission rate, high drug loading efficiency, and good capability to provide a moist environment, but they are limited in terms of antimicrobial properties. Their inability to protect the wound from microbial invasion results in wound exposure to microbial infections, resulting in a delayed wound healing process. Furthermore, some wound dressings are loaded with synthetic antibiotics that can cause adverse side effects on the patients. Natural-based compounds exhibit unique features such as good biocompatibility, reduced toxicity, etc. Curcumin, one such natural-based compound, has demonstrated several biological activities such as anticancer, antibacterial and antioxidant properties. Its good antibacterial and antioxidant activity make it beneficial for the treatment of wounds. Several researchers have developed different types of polymer-based wound dressings which were loaded with curcumin. These wound dressings displayed excellent features such as good biocompatibility, induction of skin regeneration, accelerated wound healing processes and excellent antioxidant and antibacterial activity. This review will be focused on the in vitro and in vivo therapeutic outcomes of wound dressings loaded with curcumin.

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Section: Curcumin-loaded Wound Dressingsmentioning

confidence: 99%

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

2020

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“…Chitosan/cellulose microcrystal films incorporated with curcumin were fabricated by vapor induced phase inversion (VIPI) [ 12 ]. Antibacterial curcumin/PVA/cellulose nanocrystal films were fabricated as antimicrobial wound dressing film [ 13 ]. Curcumin were entrapped in nanocellulose/chitosan hydrogel by swelling equilibrium method [ 14 ].…”

Section: Introductionmentioning

confidence: 99%

Curcumin-Loaded Bacterial Cellulose/Alginate/Gelatin as A Multifunctional Biopolymer Composite Film

et al. 2020

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Multifunctional biopolymer composites comprising mechanically-disintegrated bacterial cellulose, alginate, gelatin and curcumin plasticized with glycerol were successfully fabricated through a simple, facile, cost-effective mechanical blending and casting method. SEM images indicate a well-distributed structure of the composites. The water contact angles existed in the range of 50–70°. Measured water vapor permeability values were 300–800 g/m2/24 h, which were comparable with those of commercial dressing products. No release of curcumin from the films was observed during the immersion in PBS and artificial saliva, and the fluid uptakes were in the range of 100–700%. Films were stretchable and provided appropriate stiffness and enduring deformation. Hydrated films adhered firmly onto the skin. In vitro mucoadhesion time was found in the range of 0.5–6 h with porcine mucosa as model membrane under artificial saliva medium. The curcumin-loaded films had substantial antibacterial activity against E. coli and S. aureus. The films showed non-cytotoxicity to human keratinocytes and human gingival fibroblasts but exhibited potent anticancer activity in oral cancer cells. Therefore, these curcumin-loaded films showed their potential for use as leave-on skin applications. These versatile films can be further developed to achieve desirable characteristics for local topical patches for wound care, periodontitis and oral cancer treatment.

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“…Moreover, these compounds also protect the skin cells from oxidative damage. Skin histological studies for the test group (with phylum curcumin) show that the area of hair follicles and sebaceous glands in the dermis layer of the skin is protected (Tong et al, 2018).…”

Section: Discussionmentioning

confidence: 99%

“…This research showed that oxygen continuously spreading on the wound significantly caused a higher and faster level of wound closure. (Tong et al, 2018) (Tong et al, 2018) In vitro and in vivo…”

Section: Continuous Diffusion Oxygen (Cdo) Therapymentioning

confidence: 99%

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

Alfaqih

Sinawang

Faizah

et al. 2020

J. Ners

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Background: One of the complications caused by diabetes mellitus is the problem of diabetic foot ulcers (DFU). The management of the DFU problem can be carried out through the wound care focused on the foot using modern dressings. This research was to determine the effectiveness of modern dressings on the healing process of diabetic foot ulcers.Methods: The methods used in arranging this systematic review were (1) the identification of interventions in the literature, (2) the identification of relevant literature based on the topic and title, (3) obtaining the literature in full-text form and (4) the analysis of the results from the various interventions in the literature.Result: The literature search was carried out in several databases such as Scopus, Google Scholar and Pubmed. The samples in this article were research about the effect of modern dressings in the treatment of diabetic foot ulcers. A total of 22 evidence bases found 10 studies using the pre-experimental method, 3 RCTs, 2 quasi-experiments, 2 articles / systematic reviews, 2 perspective studies, 1 medical report, 1 case study and 1 vitro and vivo study.Conclusion: Based on the review, it explains that the research on modern dressings using nanocrystalline silver ion and curcumin can improves wound recovery by increasing the transformation rate of the ß1 growth factor, which is a protein involved in cell growth and proliferation.

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Antimicrobial wound dressing film utilizing cellulose nanocrystal as drug delivery system for curcumin

Cited by 97 publications

References 19 publications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Polymer-Based Materials Loaded with Curcumin for Wound Healing Applications

Curcumin-Loaded Bacterial Cellulose/Alginate/Gelatin as A Multifunctional Biopolymer Composite Film

The Management of Diabetic Foot Ulcers Using the Wound Treatment Techniques of Modern Dressing: A Systematic Review

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