“…Another problem in our patient sample which is the result of repeated oral antibiotic therapy, involves detrimental alterations of the oropharyngeal microflora. These alterations include jncreased colonization with Gram negative pathogens and Candida albicans (14), antibiotic resistant Staphylococcus aureus (27)(28)(29)(30), Streptococcus mitis (31) and Hemophilus influenzae (32). We have confirmed all such observations in a similar acutely ill patient sample being treated with antibiotics (1).…”