2016
DOI: 10.1152/ajplung.00373.2015
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Antimitogenic effect of bitter taste receptor agonists on airway smooth muscle cells

Abstract: -Airway remodeling is a hallmark feature of asthma and chronic obstructive pulmonary disease. Clinical studies and animal models have demonstrated increased airway smooth muscle (ASM) mass, and ASM thickness is correlated with severity of the disease. Current medications control inflammation and reverse airway obstruction effectively but have limited effect on remodeling. Recently we identified the expression of bitter taste receptors (TAS2R) on ASM cells, and activation with known TAS2R agonists resulted in A… Show more

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Cited by 54 publications
(65 citation statements)
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References 59 publications
(97 reference statements)
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“…Our previous study using human ASM cells suggest that TAS2R agonists inhibit mitogen-induced ASM growth21. The anti-remodeling effect of TAS2R agonists observed in this study may involve anti-mitogenic effect of TAS2R agonists.…”
Section: Resultssupporting
confidence: 64%
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“…Our previous study using human ASM cells suggest that TAS2R agonists inhibit mitogen-induced ASM growth21. The anti-remodeling effect of TAS2R agonists observed in this study may involve anti-mitogenic effect of TAS2R agonists.…”
Section: Resultssupporting
confidence: 64%
“…Activation of PKA is central to ASM relaxation and ASM cell growth inhibition by beta agonists9. TAS2R agonists on the other hand do not activate cAMP/PKA pathway, yet induce a robust bronchodilatory and anti-proliferative effect on airways21. These studies suggest TAS2R agonists activate novel signal transduction mechanisms in airways cells to promote anti-asthma effects.…”
Section: Discussionmentioning
confidence: 90%
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“…Cells were plated in a 96‐well plate and maintained in complete Ham's F12 medium supplemented with 10% FBS until 90% confluent. Cells were then switched to serum‐free Ham's F12 medium, and 24 h later pretreated with indicated agonists or vehicle 30 min before addition of 10 ng/ml PDGF as per (42, 43). After 72 h treatment of PDGF with vehicle or agonists, medium was changed to assay buffer containing CyQuant dye, and fluorescence intensity was measured as per the manufacturer's instructions.…”
Section: Methodsmentioning
confidence: 99%