Antimony(III) complexes with 2-benzoylpyridine-derived thiosemicarbazones: Cytotoxicity against human leukemia cell lines

Structural Studies and Investigation on the Activity of Imidazole-Derived Thiosemicarbazones and Hydrazones against Crop-Related Fungi

“…In all structures the CNNC(S)N backbone is almost planar with rms distance of atoms from the least-squares plane of 0.0277 Å (1a), 0.0137 Å (2), 0.0705 Å (3), 0.0438 and 0.0669 Å (for C10N3N4C11S1N5 and C30N23N24C31S21N25, respectively, in 4) and 0.0311 Å (5). The bond lengths in the thiosemicarbazone backbone are similar to those previously described in the literature [19,20,24,25]. (5), showing the labeling scheme of the non-H atoms and their displacement ellipsoids at the 50% probability level.…”

“…Microanalyses were compatible with the proposed formulations. The infrared spectra of the thiosemicarbazones showed a very strong band at 3,446-3,145 cm , respectively [19,20]. The NMR spectra of all thiosemicarbazones were recorded in DMSO-d 6 .…”

“…Thiosemicarbazones and hydrazones were prepared according to procedures previously employed by our group [15,19,[31][32][33]. Melting points were determined using the digital Mettler Toledo FP90 equipment.…”

“…The reaction mixture was kept under reflux for 6 h. After cooling to room temperature the resulting solids were filtered off, washed with ethanol and ether and dried in vacuum. (9)(10)(11)(12)(13)(14)(15)(16)(17)(18)(19)(20) The imidazole-derived hydrazones were prepared by mixing equimolar amounts (2 mmol) of 4(5)-imidazole-carboxaldehyde, 4-(1H-imidazole-1-yl)-benzaldehyde and 4-(1H-imidazole-1-yl)-acetophenone with the desired hydrazide in methanol with addition of three drops of acetic acid as catalyst. The reaction mixture was kept under reflux for 6 h. After cooling to room temperature the resulting solids were filtered off, washed with ethanol and ether and dried in vacuum.…”

Spectroscopic and electrochemical characterization of gold(I) and gold(III) complexes with glyoxaldehyde bis(thiosemicarbazones): cytotoxicity against human tumor cell lines and inhibition of thioredoxin reductase activity

“…In many cases coordination to metal ions leads to improvement of the pharmacological properties of this class of compounds (Lessa et al 2011;Reis et al 2010;Ferraz et al 2011). In a previous work we demonstrated that gold(I) complexes with thiosemicarbazones were effective cytotoxic agents against human tumor cell lines and that inhibition of TrxR could be involved in their mechanism of action (Lessa et al 2011).…”