Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies

Schumacher, Brianna M. Lyttle; Jukic, Anne Marie Z.; Steiner, Anne Z.

doi:10.1016/j.fertnstert.2018.01.039

Cited by 64 publications

(54 citation statements)

References 27 publications

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“…Prior studies have suggested that low anti-Mullerian hormone level (≤0.4ng/mL) is associated with an increased risk of miscarriage [20]. In the current study, a statistically significant relationship was determined between AMH and the antral follicle count.…”

Section: Discussionmentioning

confidence: 56%

“…Reduced rates of becoming pregnant, together with increased rates of the birth of infants with anomalies and rates of miscarriage are seen with increasing age and decreasing ovarian reserve [10,11]. The probable reason for this is thought to be the diminished quality of the eggs remaining in the reduced ovarian reserve associated with increasing age [12]. The extended exposure of eggs to toxic mutant agents due to increased maternal age may be the cause of a deterioration in quality due to DNA damage and the formation of DNA methylation [13].…”

Section: Discussionmentioning

confidence: 99%

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Ovarian reserve testing in the prediction of recurrent pregnancy loss

KÜKRER¹,

Arlıer²,

Karaman³

2020

Journal of Surgery and Medicine

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Aim: Approximately 1-2% of reproductive women have faced recurrent pregnancy loss (RPL). Ovarian reserve testing in the prediction of recurrent pregnancy loss is not usually performed. In this study, we aim to evaluate whether there were any differences between patients with and without a history of recurrent pregnancy loss (RPL) with regards to anti-Mullerian hormone (AMH), follicle stimulating hormone (FSH), luteinizing hormone (Lh), estradiol (E2) levels and basal follicle count. Methods: This case-control study was conducted between 1 January 2013 and 1 January 2015 in the Gynecology and Obstetrics Clinic of Adana Numune Training and Research Hospital. A total of 370 patients aged 17-37 years with a diagnosis of RPL during that 2-year period were contacted by telephone. Further evaluation was made of 40 patients who met the study criteria and gave verbal consent. Patients were called to the Gynecology Polyclinic for assessment on the 3rd day of their menstrual cycle, and a control group was formed of 40 patients with similar demographic characteristics who were referred to the Gynecology Polyclinic and met the study criteria. Results: The mean basal follicle count was determined as 9.4 (2.7) in the study group and 8.9 (2.5) in the control group (P=0.092). The mean AMH values in the RPL and control groups were 3.50 (1.92) ng/mL and 3.66 (2.14) ng/mL, respectively (P=0.718). The mean FSH values in the RPL and control groups were 6.77 (1.87) mIU/mL and 7.01 (1.90) mIU/mL, respectively (P=0.494). Mean LH values were measured as 5.6 (1.8) mIU/mL in the study group and 4.9 (1.7) mIU/mL in the control group. Mean E2 values were 87.7 (83.9) pg/mL and 48.4 (27.9) pg/mL in the study and control groups, respectively. Conclusion: While no difference was found between the RPL and control groups in respect of AMH and FSH values in the ovarian reserve tests, the basal follicle count of the patients with recurrent pregnancy loss was found lower than that of the control group.

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Section: Discussionmentioning

confidence: 56%

Section: Discussionmentioning

confidence: 99%

Ovarian reserve testing in the prediction of recurrent pregnancy loss

KÜKRER¹,

Arlıer²,

Karaman³

2020

Journal of Surgery and Medicine

View full text Add to dashboard Cite

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“…They also showed that maternal age did not affect the relationship between serum AMH concentration and risk of abortion, suggesting that low AMH is an independent risk factor for spontaneous abortion. 16 In contrast, Zarek et al 9 reported that serum AMH was not associated with clinical pregnancy loss after unassisted conception among women with 1-2 previous pregnancy losses. In their study, neither low (<1.0 ng/mL) nor high (>3.5 ng/mL) AMH relative to normal values (1.0-3.5 ng/mL) was associated with clinical pregnancy loss.…”

Section: Discussionmentioning

confidence: 96%

“…Although this has been previously reported, only a few studies have been conducted among women with a naturally conceived pregnancy. Lyttle Schumacher et al . reported that women with a severely diminished ovarian reserve (AMH, ≤0.4 ng/mL) were at increased risk of abortion, which in turn reversed with rising AMH concentrations.…”

Section: Discussionmentioning

confidence: 99%

“…Although this has been previously reported, only a few studies have been conducted among women with a naturally conceived pregnancy. Lyttle Schumacher et al 16 reported that women with a severely diminished ovarian reserve (AMH, ≤0.4 ng/mL) were at increased risk of abortion, which in turn reversed with rising AMH concentrations. They also showed that maternal age did not affect the relationship between serum AMH concentration and risk of abortion, suggesting that low AMH is an independent risk factor for spontaneous abortion.…”

Section: Discussionmentioning

confidence: 99%

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Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Kostrzewa

Żyła

Horzelski

et al. 2020

Intl J Gynecology & Obste

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Objective To assess anti‐Müllerian hormone (AMH) levels as a marker of early abortion in the first trimester among women younger than 35 years. Methods Prospective study of women aged 18–34 years with a spontaneous pregnancy at less than 12.6 gestational weeks in Łódź, Poland, between January 2017 and November 2018. Cases of anembryonic abortion and assisted conception were excluded. Blood samples were collected and assayed for serum AMH levels. Data were compared between women with an embryo with no cardiac activity by ultrasound (n=30) and those with a normal embryo (n=33) by using Statistica12 software. Results The 10th and 90th percentiles of serum AMH concentration among control women were used to identify a reference AMH range (1.1–4.5 ng/mL). Risk of pregnancy loss in the first trimester was found to be higher for both low AMH (<1.1 ng/mL; relative risk [RR], 3.66; 95% confidence interval [CI], 2.1–6.4; P<0.001) and high AMH (>4.5 ng/mL; RR, 3.0; 95% CI, 1.61–5.59; P<0.001). Conclusions Both very low and very high AMH concentrations were found to significantly increase the risk of abortion in the first trimester of pregnancy. Serum AMH might be a valuable marker to predict the risk of early abortion.

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Evaluating the efficacy of ovulation stimulation with intrauterine insemination in women with diminished ovarian reserve compared to women with normal ovarian reserve

Kaleli

Kervancıoğlu

Erol

et al. 2022

Intl J Gynecology & Obste

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Objective To assess the efficacy of ovulation induction and intrauterine insemination (IUI) in couples with diminished ovarian reserve (DOR). Methods Women aged 20–39 years and men younger than 50 years were included. Four “ovarian reserve groups” were created according to anti‐Müllerian hormone (AMH) and the partner's age. Gestational sac finding on ultrasound examination was the primary outcome measure. Results The study was carried out on a total of 770 cycles of 362 women in an infertility cohort that consisted of 75 women with DOR treated by 153 cycles and 287 women without DOR treated by 617 cycles. The pregnancy rate was similar in the four ovarian reserve groups in terms of first, second, third plus fourth, and total attempts of IUI cycles. Moreover, the pregnancy rate, miscarriage rate, and multiple pregnancy rate were similar. We found no difference in the cumulative pregnancy rate among the groups after four IUI cycles. Multivariate logistic regression analysis of the entire cohort revealed that infertility duration, post‐wash sperm count, and follicle number greater than 11 mm on the day of human chorionic gonadotropin trigger were independent predictors of pregnancy (P < 0.001). Neither age nor AMH predicted pregnancy after ovulation stimulation and IUI. Conclusions Ovulation stimulation and IUI are equally effective in women with DOR and in women with normal ovarian reserve in terms of pregnancy rate, multiple pregnancy rate, and miscarriage rate per IUI cycle or cumulative pregnancy rate after four cycles of IUI.

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Antimüllerian hormone as a risk factor for miscarriage in naturally conceived pregnancies

Abstract: AMH levels are inversely associated with the risk of miscarriage. Women with severely diminished ovarian reserve are at an increased risk of miscarriage.

Cited by 64 publications

References 27 publications

Ovarian reserve testing in the prediction of recurrent pregnancy loss

Ovarian reserve testing in the prediction of recurrent pregnancy loss

Anti‐Müllerian hormone as a marker of abortion in the first trimester of spontaneous pregnancy

Evaluating the efficacy of ovulation stimulation with intrauterine insemination in women with diminished ovarian reserve compared to women with normal ovarian reserve

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