Antimutagenic Activities of Phenolic Plant Flavonoids

Abstract

Total phenolic plant fiavonoids obtained from Thuia accidentalis L. and Cupressus sempevirens L. showed antimutagenic effects on benzofa) pyrene [B(a)P] in Salmonella typhimurium strains TAlOO and TA98. The n-butanol extract was more effective then chloroform and petrol eum-ether extracts, respectively. Aqueous extracts exhibited no inhibition in both strains. Total Javonoids from C. sempevirens showed more antimutagenic activity than fiavonoids from T. accidentalis. None of the extracts revealed any cytotoxic or mutagenic activity on the bacterial tester strains.