Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua

Park, Kun-Young; Jung, Geun-Ok; Lee, Kyung‐Tae; Choi, Jongwon; Choi, Moo-Young; Kim, Gab-Tae; Jung, Hyun‐Ju; Park, Hee-Juhn

doi:10.1016/j.jep.2003.09.043

Cited by 163 publications

(81 citation statements)

References 15 publications

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“…Rhus verniciflua, a deciduous tree in the anacardiaceae family, exhibits a variety of biological activities such as antioxidant [11,12], anti-microbial [13], anti-cancer [14,15], and anti-platelet properties [16]. However, the chemical components of Rhus verniciflua and their biological properties have not been fully elucidated.…”

Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated fromRhus vernicifluain LPS-stimulated BV2 Microglial Cells

Lee

Cheong

Kim

et al. 2011

Korean J Physiol Pharmacol

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Section: Introductionmentioning

confidence: 99%

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated fromRhus vernicifluain LPS-stimulated BV2 Microglial Cells

Lee

Cheong

Kim

et al. 2011

Korean J Physiol Pharmacol

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“…Unlike the stem bark, which contains allergenic urshinols, the heartwood does not have an allergenic effect and has been traditionally used as a food additive and herbal medicine to treat rheumatoid arthritis. Recently, the methanol extract of Rhus verniciflua heartwood, which contains fustin, showed anti-rheumatoid arthritis and antimutagenic activities which were found to be mediated via antioxidant activity (Choi et al, 2003;Park et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Protective effects of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-hydroxydopamine-induced neuronal cell death

Park

Lee²,

Park³

et al. 2007

Exp Mol Med

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Abstract6-Hydroxydopamine (6-OHDA) is a neurotoxin and is commonly used to generate experimental models of Parkinson's disease (PD). In this study, we investigated the signaling molecules involved in the 6-OHDA-induced cell death using a neuronal catecholaminergic cell line (SK-N-SH cells), and the protective effect of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-OHDA-induced neuronal death. 6-OHDA significantly increased levels of reactive oxygen species (ROS), intracellular Ca 2+ ([Ca 2+ ] i ), and p38 phosphorylation. In addition, this ROS increase by 6-OHDA was reduced by pretreatment with N-acetylcysteine (NAC), a free radical scavenger, but not by bis-(o-aminophenoxy)-ethane-N,N,N,Ntetraacetic acid (BAPTA), a Ca 2+ chelator. However, the [Ca 2+ ] i increase induced by 6-OHDA was suppressed by NAC. Moreover, pretreatment with NAC or BAPTA significantly prevented the 6-OHDAinduced increases in p38 phosphorylation, Bax/ Bcl-2 ratio, and caspase-3 activity. Although 6-OHDA-increased phosphorylation of p38 was prevented by NAC or BAPTA, inhibition of p38 by SB203580 did not suppress ROS, Bax/Bcl-2 ratio, or caspase-3 activity increases, and only partially prevented 6-OHDA-induced cell death, thus demonstrating that p38 activation is a component of a signaling pathway leading to the initiation of 6-OHDA-induced cell death, which acts in parallel with an ROS-Ca 2+ -Bcl-2-caspase-3 pathway. Moreover, fustin not only suppressed 6-OHDA-induced cell death in a concentration-dependent manner but also blocked 6-OHDA-induced increases in ROS, [Ca 2+ ] i , Bax/Bcl-2 ratio, caspase-3 activity, and p38 phosphorylation. These results suggest that fustin exerts neuroprotection against 6-OHDA-induced cell death.

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“…Flavonoids have antioxidant activities, remove free radicals, and exhibit antigenotoxic activity. Procyanidins show a variety of activities, such as antioxidative, anti-inflammatory, and tyrosinase inhibition (Miyake et al, 2008); however, they may have genotoxic effects in high concentrations (Nogueira et al, 2001;Park et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Assessment of toxic, genotoxic, antigenotoxic, and recombinogenic activities of Hymenaea courbaril (Fabaceae) in Drosophila melanogaster and mice

Vale¹,

Silva²,

Oliveira³

et al. 2013

Genet. Mol. Res.

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ABSTRACT. Hymenaea courbaril L., popularly known as jatobá, is a plant species that grows in the forests of South America. The species has been used for culinary purposes and in folk medicine to treat arthritis and inflammations. Due to the increasing use of this plant globally, the present study aimed to evaluate the toxic, genotoxic, recombinogenic, and antigenotoxic effects of H. courbaril sap (Hycs) using the mouse bone marrow micronucleus test and the somatic mutation and recombination test (SMART) in Drosophila melanogaster. To evaluate the aneugenic and clastogenic activities revealed by the micronucleus test, the animals were treated with 3 doses of Hycs (5, 10, and 15 mL/kg body weight). To evaluate the antianeugenic and anticlastogenic activities, the animals were simultaneously treated with Hycs and mitomycin C (4 mg/kg body weight). To assess the mutagenic and recombinogenic activities using SMART, 3-day-old larvae derived from standard and high bioactivation crosses were treated with 3 doses of Hycs (3.0, 1.5, and 0.3 mL) for approximately 48 h. To evaluate antimutagenic and antirecombinogenic Protective effects of jatobá in mice and D. melanogaster activities, larvae derived from both crosses were co-treated with 3 doses of Hycs (3.0, 1.5, and 0.3 mL) and doxorubicin (0.125 mg/ mL). The mouse bone marrow micronucleus test revealed that Hycs exhibited no cytotoxic, clastogenic and/or aneugenic effects, but did show anticytotoxic, anticlastogenic and/or antianeugenic activities. The SMART revealed no mutagenic or recombinogenic effects, but antimutagenic and antirecombinogenic activities were observed in somatic cells of D. melanogaster from both crosses.

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Antimutagenic activity of flavonoids from the heartwood of Rhus verniciflua

Cited by 163 publications

References 15 publications

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated fromRhus vernicifluain LPS-stimulated BV2 Microglial Cells

Anti-inflammatory Activity of 1-docosanoyl Cafferate Isolated fromRhus vernicifluain LPS-stimulated BV2 Microglial Cells

Protective effects of fustin, a flavonoid from Rhus verniciflua Stokes, on 6-hydroxydopamine-induced neuronal cell death

Assessment of toxic, genotoxic, antigenotoxic, and recombinogenic activities of Hymenaea courbaril (Fabaceae) in Drosophila melanogaster and mice

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