Antimutagenic and anticarcinogenic effects of wheat bran in vivo

Pesarini, João Renato; Zaninetti, Paula Thaissa; Mauro, M O; Carreira, Clisia Mara; Dichi, Jane Bandeira; Ribeiro, L.R; Mantovani, Mário Sérgio; Oliveira, Rodrigo Juliano

doi:10.4238/2013.may.14.5

Cited by 19 publications

(29 citation statements)

References 38 publications

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“…The collection of blood samples (caudal puncture) was carried out on 24 h (T1) to evaluate the (anti) genotoxicity by the comet assay and 24, 48, and 72 h, corresponding to T1, T2, and T3, respectively, to evaluate the (anti) mutagenicity using the micronucleus test. At the end of the experimentation period (12 weeks) the animals were euthanized for evaluation of (anti) carcinogenicity through the foci of aberrant crypts Pesarini et al, 2013;Navarro et al, 2015). The control group received distilled water by gavage every day until the 12th week.…”

Section: Experimental Designmentioning

confidence: 99%

“…administered twice a week for two consecutive weeks, intraperitoneally (ip) (Ishii et al, 2011;Mauro et al, 2013;Cantero et al, 2015;Navarro et al, 2015). During the use, DMH was diluted in EDTA solution (0.37 mg/mL) with the same solution used as a vehicle for the control group treatment (Ishii et al, 2011;Mauro et al, 2013;Pesarini et al, 2013;Cantero et al, 2015;Navarro et al, 2015). DMH is an indirect trigger of colorectal carcinogenesis andone of the most used drugs in experimental models (Jucá et al, 2014).…”

Section: Induction Of Colorectal Carcinogenesismentioning

confidence: 99%

“…In contrast, high intake of fiber (prebiotics) can reduce the risk of colon cancer (Ishii et al, 2011;Pesarini et al, 2013;Mauro et al, 2013;Cantero et al, 2015;Navarro et al, 2015). Besides prebiotics and probiotics (Cui et al, 2013), the symbiotic relationship between immune cells and gut microbiota (Yamamoto and Matsumoto, 2016) in the prevention of this disease also needs to be highlighted.…”

Section: Introductionmentioning

confidence: 99%

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Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

et al. 2017

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ABSTRACT. Colorectal cancer is a global public health issue. Studies have pointed to the protective effect of probiotics on colorectal carcinogenesis. Activia ® is a lacto probiotic product that is widely consumed all over the world and its beneficial properties are related, mainly, to the lineage of traditional yoghurt bacteria combined with a specific bacillus, DanRegularis, which gives the product a proven capacity to intestinal regulation in humans. The aim of this study was to evaluate the antigenotoxic, antimutagenic, and anticarcinogenic proprieties of the Activia product, in response to damage caused by 1,2-dimethylhydrazine (DMH) in Swiss mice. Activia does not have shown antigenotoxic activity. However, the percent of DNA damage reduction, evaluated by the antimutagenicity assay, ranged from 69.23 to 96.15% indicating effective chemopreventive action. Activia reduced up to 79.82% the induction of aberrant crypt foci by DMH. Facing the results, it is inferred that Activia facilitates the weight loss, prevents DNA damage and pre-cancerous lesions in the intestinal mucosa.

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Section: Experimental Designmentioning

confidence: 99%

Section: Induction Of Colorectal Carcinogenesismentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

et al. 2017

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“…The animals were treated for 120 days according to the protocols of Mauro et al (2013) and Pesarini et al (2013), with modifications. The experimental groups are described below.…”

Section: Experimental Designmentioning

confidence: 99%

“…Diets with these characteristics are generally rich in pre-and probiotics (Burns and Rowland, 2004;Mauro et al, 2013;Pesarini et al, 2013).…”

Section: Introductionmentioning

confidence: 99%

Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses

Cantero¹,

Takahachi²,

Mauro³

et al. 2015

Genet. Mol. Res.

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ABSTRACT. The present study investigated the effects of restricting protein and calories and supplementation of inulin, a fiber comprising a linear type of polydisperse carbohydrates composed primarily of 2423 ©FUNPEC-RP www.funpecrp.com.br Genetics and Molecular Research 14 (1): 2422-2435 (2015) Inulin prevents cancer in malnourished animals fructil-fructose bonds (β-(2→1), on the deficiency statuses of animals in which genomic lesion development and colorectal carcinogenesis had been induced. This experiment involved adult male Swiss mice (N = 11/group). The experimental groups were as follows: Negative Control (vehicle), Positive Control, 1,2-dimethylhydrazine (DMH), Inulin, and Associate. DMH, which promoted colorectal cancer, was administered intraperitoneally in 4 20-mg/kg body weight (bw) doses during a 2-week period; inulin was administered orally at a daily dose of 50 mg/kg bw. Each group was bifurcated; half of each group was fed a normal protein diet and the other half was fed a low-protein diet. The results indicated that a correlation existed between malnutrition and an increased frequency of genomic lesions but that malnutrition did not predispose animals to colorectal cancer development. Inulin exhibited genotoxic activity, which requires further investigation, and low antigenotoxic activity. Moreover, inulin reduced the levels of intestinal carcinogenesis biomarkers in both malnourished and healthy animals. These data suggest that inulin holds therapeutic potential and is a strong candidate for inclusion among the functional foods used for cancer prevention in both properly nourished and malnourished individuals.

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Dietary Fiber and Colon Cancer

Maldonado¹,

Urango

2016

Dietary Fiber Functionality in Food and Nutraceuticals

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Antimutagenic and anticarcinogenic effects of wheat bran in vivo

Cited by 19 publications

References 38 publications

Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

Prevention of DNA damage and anticarcinogenic activity of Activia<sup>®</sup> in a preclinical model

Genomic lesions and colorectal carcinogenesis: the effects of protein-calorie restriction and inulin supplementation on deficiency statuses

Dietary Fiber and Colon Cancer

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