Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions

Shon, Mi-Yae; Choi, Seok-Ki; Kahng, Goon-Gjung; Nam, Sanghae; Sung, Nak‐Ju

doi:10.1016/j.fct.2003.12.002

Cited by 250 publications

(132 citation statements)

References 28 publications

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“…AFB1 is produced by some strains of Aspergillus and ingestion of aflatoxin-contaminated food and feed is known to cause hepatotoxicity, teratogenicity, immunotoxicity and even death in farm animals and humans (Guindon et al 2007). The mechanism of cellular damage caused by AFB1 has not been fully elucidated but reactive oxygen species (ROS) and lipid peroxidation (LPO) have been considered to be main mechanisms in the toxicity of AFB1 (Rastogi et al 2001;Shon et al 2004). Finally, AFB1 causes micronucleus (MN), sister chromatid exchanges (SCEs), unscheduled DNA synthesis, and chromosomal strand breaks as well as forms adducts in rodent and human cells (Groopman and Kensler 1999).…”

Section: Introductionmentioning

confidence: 99%

“…So far, antioxidants have attracted much interest with respect to their protective effect against free radical damage that may be the cause of many diseases including cancer (Shon et al 2004). Since the complete avoidance of exposure to AFB1-producing mould is very difficult, chemoprevention is an attractive strategy for protecting humans and animals from the risk of cancer caused by exposure to this mycotoxin.…”

Section: Introductionmentioning

confidence: 99%

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In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

et al. 2012

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A common dietary contaminant, aflatoxin B1 (AFB1), has been shown to be a potent mutagen and carcinogen in humans and many animal species. Since the eradication of AFB1 contamination in agricultural products has been rare, the use of natural or synthetic free radical scavengers could be a potential chemopreventive strategy. Boron compounds like borax (BX) and boric acid are the major components of industry and their antioxidant role has recently been reported. In the present report, we evaluated the capability of BX to inhibit the rate of micronucleus (MN) and sister chromatid exchange (SCE) formations induced by AFB1. There were significant increases (P \ 0.05) in both SCE and MN frequencies of cultures treated with AFB1 (3.12 ppm) as compared to controls. However, co-application of BX (1, 2 and 5 ppm) and AFB1 resulted in decreases of SCE and MN rates as compared to the group treated with AFB1 alone. Borax gave 30-50 % protection against AFB1 induced SCEs and MNs. In conclusion, the support of borax was especially useful in aflatoxintoxicated blood tissue. Thus, the risk on target tissues of AFB1 could be reduced and ensured early recovery from its toxicity.

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

et al. 2012

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“…So far, antioxidants have attracted much interest with respect to their protective effect against damage by free radical that may be the cause for many diseases including cancer (Shon et al 2004). Since the complete avoidance of exposure to PM is very difficult, chemoprevention is an attractive strategy for protecting humans and animals from the risk of cancer caused by exposure to this insecticide.…”

Section: Introductionmentioning

confidence: 99%

Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats

2012

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Permethrin is a common synthetic chemical, widely used as an insecticide in agriculture and other domestic applications. The previous reports indicated that permethrin is a highly toxic synthetic pyrethroid pesticide to human and environmental health. Therefore, the present experiment was undertaken to determine the effectiveness of olive leaf extract in modulating the permethrin induced genotoxic and oxidative damage in rats. The animals used were broadly divided into four (A, B, C and D) experimental groups. Group A rats served as control animals and received distilled water intraperitoneally (n = 5). Groups B and C rats received intraperitoneal injections of permethrin (60 mg kg -1 b.w) and olive leaf extract (500 mg kg -1 b.w), respectively. Group D rats received permethrin (60 mg kg -1 b.w) plus olive leaf extract (500 mg kg -1 b.w). Rats were orally administered their respective feed daily for 21 days. At the end of the experiment rats were anesthetized and serum and bone marrow cell samples were obtained. Genotoxic damage was assessed by micronucleus and chromosomal aberration assays. Total antioxidant capacity and total oxidant status were also measured in serum samples to assess oxidative status. Treatment of Group B with permethrin resulted in genotoxic damage and increased total oxidant status levels. Permethrin treatment also significantly decreased (P \ 0.05) total antioxidant capacity level when compared to Group A rats. Group C rats showed significant increases (P \ 0.05) in total antioxidant capacity level and no alterations in cytogenetic parameters. Moreover, simultaneous treatments with olive leaf extract significantly modulated the toxic effects of permethrin in Group D rats. It can be concluded that olive leaf extract has beneficial influences and could be able to antagonize permethrin toxicity. As a result, this investigation clearly revealed the protective role of olive leaf extract against the genetic and oxidative damage by permethrin in vivo for the first time.

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“…The mechanism of cellular damage caused by AFB 1 has not been fully elucidated (Rastogi et al 2001). Reactive oxygen species (ROS) and lipid peroxidation (LPO) have been considered to be main mechanisms in the toxicity of AFB 1 (Shon et al 2004). Finally, AFB 1 causes micronucleus (MN), sister chromatid exchanges (SCEs), unscheduled DNA synthesis, and chromosomal strand breaks as well as forms adducts in rodent and human cells (Groopman and Kensler 1999).…”

Section: Introductionmentioning

confidence: 99%

“…So far, antioxidants have attracted much interest with respect to their protective effect against damage by free radical that may be the cause for many diseases including cancer (Shon et al 2004). Since the complete avoidance of exposure to AFB 1 -producing mould is very difficult, chemoprevention is an attractive strategy for protecting humans and animals from the risk of cancer caused by exposure to this mycotoxin.…”

Section: Introductionmentioning

confidence: 99%

Boric acid: a potential chemoprotective agent against aflatoxin b1 toxicity in human blood

Türkez

Geyikoğlu

2010

Cytotechnology

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Aflatoxin B 1 is the most potent pulmonary and hepatic carcinogen. Since the eradication of Aflatoxin B 1 contamination in agricultural products has been difficult, the use of natural or synthetic free radical scavengers could be a potential chemopreventive strategy. Boric acid is the major component of industry and its antioxidant role has recently been reported. The present study assessed, for the first time, the effectiveness of boric acid following exposure to Aflatoxin B 1 on human whole blood cultures. The biochemical characterizations of glutathione and some enzymes have been carried out in erythrocytes. Alterations in malondialdehyde level were determined as an index of oxidative stress. The sister-chromatid exchange and micronucleus tests were performed to assess DNA damages in lymphocytes. Aflatoxin B 1 treatment significantly reduced the activities of antioxidants by increasing malondialdehyde level (30.53 and 51.43%) of blood, whereas, the boric acid led to an increased resistance of DNA to oxidative damage induced by Aflatoxin B 1 in comparison with control values (P \ 0.05). In conclusion, the support of boric acid was especially useful in Aflatoxin-toxicated blood. Thus the risk on tissue targeting of Aflatoxin B 1 could be reduced ensuring early recovery from its toxicity.

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Antimutagenic, antioxidant and free radical scavenging activity of ethyl acetate extracts from white, yellow and red onions

Cited by 250 publications

References 28 publications

In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

In vitro studies on chemoprotective effect of borax against aflatoxin B1-induced genetic damage in human lymphocytes

Olive leaf extract modulates permethrin induced genetic and oxidative damage in rats

Boric acid: a potential chemoprotective agent against aflatoxin b1 toxicity in human blood

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