Antimutagenic Constituents from the Thorns of Gleditsia sinensis

Chemical Constituents of Kosteletzkya batacensis (Blanco) Fern.-Vill.

“…β-Sitosterol (5a) inhibited human breast MCF-7 and MDA-MB-231 adenocarcinoma cells [26], used for the treatment of benign prostatic hyperplasia [27], chemopreventive potential against colon cancer [28], attenuated β-catenin and PCNA expression, inhibited the expression of NPC1L1 [29], induced apoptosis mediated by the activation of ERK and down regulated Akt in MCA-102 murine fibrosarcoma cells [30]. Stigmasterol (5b) showed therapeutic efficacy against Ehrlich ascites carcinoma in mice [31], lowered plasma cholesterol levels, inhibited intestinal cholesterol and plant sterol absorption, suppressed hepatic cholesterol and classic bile acid synthesis in Winstar and WKY rats [32], exhibited cytostatic activity against Hep-2 and McCoy cells [33], markedly inhibited tumour promotion in two stage carcinogenesis experiments [34] and exhibited antimutagenic [35], topical antiinflammatory [36], antiosteoarthritic [37] and antioxidant [38] activities.…”

Osteoclast-Forming Suppressive Compounds from Makomotake,Zizania latifoliaInfected withUstilago esculenta

“…Compound 2 has been isolated as an antimutagenic constituent from the thorns of Gleditsia sinebsis, and the full assignments of all the 1 H-and 13 C-NMR signals and determination of the stereochemistry were made by various spectral data. 4,5) Compounds 1 and 2 were evaluated in an osteoclastforming suppression assay. The addition of 1 (25 mg/ml, 53 mM) and 2 (25 mg/ml, 58 mM) reduced the respective number of TRAP-(+) multinucleated cells to 49% and 19% without cytotoxicity.…”

Isolation and structure identification of new cytokinins from Gleditsia caspia

“…8 Our literature survey indicated that triterpenoidal saponins, steroids, alkaloids, and flavonoids have been isolated from the genus Gleditsia. [9][10][11] We report here the isolation and structural characterization of three new cytokinins isolated for the first time from the natural source. …”