Antimutagenic potential of homoisoflavonoids from Muscari racemosum

Miadoková, Eva; Maśterová, I; Vlčková, Viera; Dúhová, V.; Toth, John P.

doi:10.1016/s0378-8741(02)00135-6

Cited by 49 publications

(29 citation statements)

References 22 publications

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“…Brachycerine, as well as the leaf extract of P. brachyceras, showed a pronounced effect at all doses tested (Table III). This antimutagenic action is probably due to the antioxidant activity of these substances, as previously observed for extracts of other medicinal plant species [Weisburger et al, 1996;Miadoková et al, 2002;Saha et al, 2004;Bruni et al, 2006].…”

Section: Discussionsupporting

confidence: 70%

Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras

Nascimento

Fragoso

Moura

et al. 2007

Environ and Mol Mutagen

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The monoterpene indole alkaloid brachycerine from Psychotria brachyceras has been shown to be induced by UV and to have in vitro antioxidant activity, indicating a possible protective role against the secondary effects of this radiation. In this work, we have studied the antioxidant properties of brachycerine and a crude foliar extract from P. brachyceras by using Saccharomyces cerevisiae strains proficient and deficient in antioxidant defenses. The mutagenic and antimutagenic potential of these substances were assayed in S.cerevisiae N123 strain in the presence and absence of H2O2. In addition, we tested the antioxidant capacity of brachycerine and a crude foliar extract from P. brachyceras on hydroxyl radicals (OH) using the hypoxanthine/xanthine oxidase assay. The results show that brachycerine and the crude foliar extract of P. brachyceras have antioxidant and antimutagenic effects in yeast and probably this action is mainly due to the scavenging of OH radicals.

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Section: Discussionsupporting

confidence: 70%

Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras

Nascimento

Fragoso

Moura

et al. 2007

Environ and Mol Mutagen

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“…are homoisoflavonoids, that confer a strong antioxidant capacity and have antimutagenic properties. 30 The effect of antioxidants on the scavenging activity of DPPH radical is due to their hydrogen-donating ability, with the reduction of the stable free radical DPPH to the yellow-colored 1,1-diphenyl-2-picrylhydrazyl free radical. This method offers the first approach for evaluating the antioxidant potential of a compound, an extract or other biological sources.…”

Section: Antioxidant Activitymentioning

confidence: 99%

Antioxidant, Enzyme-Inhibitory and Antitumor Activity of the Wild Dietary Plant Muscari comosum (L.) Mill.

Casacchia

Sofo

Casaburi

et al. 2017

IJPB

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Conventional medicines used to treat obesity and cancer frequently exhibit high side effects, so that researchers are focusing on new therapies and drugs based on natural products. Total extracts from bulbs of Muscari comosum were tested for i) free radical scavenging activity, ii) in vitro enzymatic inhibition of pancreatic α-amylase and lipase, and iii) inhibition of the growth of breast adenocarcinoma cells. Three treatments were considered: bulbs boiled in water for 15 min (traditional cooking method; BB); bulbs steam-cooked for 15 min (alternative cooking method; SB); raw bulbs (RB). The polyphenol content and antioxidant capacity of bulb extracts were related to the inhibition of pancreatic lipase and α-amylase, whose activities have been found to have a half maximal inhibitory concentration (IC 50 ) of 0.28, 2.14 and 3.22 mg/mL for lipase, and 0.16, 0.73 and 0.69 mg/mL for α-amylase in RB, SB and BB, respectively. The analysis on breast adenocarcinoma MCF-7 cells revealed that RB extracts, and in a lesser extent BB, exerted a dose-dependent inhibition on cell proliferation. Considering that the potential of natural products for the treatment of obesity are under exploration, M. comosum could be an excellent plant for the development of future anti-obesity drugs, also able to prevent cancer.

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“…Therefore, the development of new compounds with antidepressant properties which additionally display antimutagenic and possibly chemopreventive properties is of great practical and therapeutic significance. 9 To evaluate mutagenic activity of new compounds many short-term and highly sensitive tests were introduced. 10,11 A general strategy behind mutagenicity testing is to apply a diversified set of tests to cover all of the main mutagenicity endpoints.…”

Section: Introductionmentioning

confidence: 99%

Preliminary Safety Assessment of New Azinesulfonamide Analogs of Aripiprazole using Prokaryotic Models

Powroźnik¹,

Słoczyńska²,

Marciniec³

et al. 2016

Adv Pharm Bull

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IntroductionOver the last decades the involvement of reactive oxygen species (ROS) in the molecular mechanisms related to psychiatric disorders such as depression or schizophrenia became evident. [1][2][3] In rat models of depression a decreased activity of antioxidant enzymes such as glutathione peroxidase (GSH-Px) followed by increased lipid peroxidation were observed. [4][5][6] Furthermore, in patients with depression the elevated plasma ROS levels were observed to effectively amplify oxidative stress.

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Antimutagenic potential of homoisoflavonoids from Muscari racemosum

Cited by 49 publications

References 22 publications

Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras

Antioxidant and antimutagenic effects of the crude foliar extract and the alkaloid brachycerine of Psychotria brachyceras

Antioxidant, Enzyme-Inhibitory and Antitumor Activity of the Wild Dietary Plant Muscari comosum (L.) Mill.

Preliminary Safety Assessment of New Azinesulfonamide Analogs of Aripiprazole using Prokaryotic Models

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