Antimutagenic potential of the Thai herb, Mucuna collettii Lace

Cherdshewasart, Wichai; Sutjit, Wandee; Pulcharoen, Kade; Panriansaen, Rattana; Chulasiri, Malyn

doi:10.1016/j.jep.2007.09.008

Cited by 11 publications

(7 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…To some extents, it is therefore, logical to say that there is a direct relationship between phenolic contents, antioxidant and antimutagenic activities. This is in line with the opinions of some investigators who previously used Ames test to evaluate mutagenicity and antimutagenicity of plant extracts and fruit juices (Zahin et al, 2010;Schneider et al, 1997;Cherdshewasart et al, 2008;Ham et al, 2009;Karekar et al, 2000;Oh et al, 2008;Rauscher et al, 1998;Son et al, 2003). In the other of FDFJ except M. fragrans, induction of negative percentage reduction of CP-induced CA or total arrest of cell division by the mixture of the FDFJ and CP at certain concentrations may be due to prooxidative activity of phenoilc compounds, causing generation of ROS to cause more DNA damages.…”

Section: Effects Of the Fdfj On A Cepa Chromosomessupporting

confidence: 85%

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Akinboro¹,

Mohamed²,

Asmawi³

et al. 2011

Afr. J. Biotechnol.

View full text Add to dashboard Cite

Mutagenic and antimutagenic activities of freeze dried fruit juices (FDFJ) ofTesting the mutagenic activity, onions were suspended in solution of different concentrations of FDFJ alone in tap water for 48 h. Thereafter, root tips were prepared and observed for dividing cells and chromosomal aberrations using a light microscope. Antimutagenicity screening was similar to the mutagenic evaluation, except that the solution of FDFJ was combined with 0.1% cylophosphamide-CP. Free radicals (2,2-diphenyl-1-picrylhyrazyl) scavenging activity of the FDFJ was tested using butylated hydroxylanisole (BHA) and butylated hydroxytoluene (BHT) as the standards and their phenolic contents were evaluated by comparing with gallic acid equivalents (GAE). The free radicals scavenging power of M. fragrans at 1 mg/ml was almost similar to that of BHA and BHT and its phenolic content was 21 ± 6.0 mg GAE/g, the highest among the tested juices. A. cepa cell division was inhibited in a dose-dependent manner by the FDFJ of M. fragrans, while the induced chromosomal aberrations were non dose dependent. The cytotoxicity and chromosomal aberrations of CP were suppressed throughout the tested concentrations of M. fragrans, unlike the effects of other four juices. These results suggest that the observed activities of FDFJ of M. fragrans may be due to the quantity and quality of phenolic compounds with antioxidant activity, suggesting its use in preventing the DNAdamaging effects of mutagens.

show abstract

Section: Effects Of the Fdfj On A Cepa Chromosomessupporting

confidence: 85%

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Akinboro¹,

Mohamed²,

Asmawi³

et al. 2011

Afr. J. Biotechnol.

View full text Add to dashboard Cite

show abstract

“…Antimutagenic activity in the Ames test revealed that the P. mirifica extracts exhibited a higher antimutagenic than either the P. lobata extracts or puerarin, the key plant isoflavonoids. However, the antimutagenic potentials of these two plant extracts were still lower than that of another Thai herb, Mucuna collettii submitted to the same test (30). Thus, although not mutagenic, these two herbs are not likely to be preferred to others such as M. collettii for preventive medication against cancer, but are likely to continue to be used for the current purposes.…”

Section: (Unpaired Student T-test)mentioning

confidence: 91%

The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata

Cherdshewasart

Sutjit

Pulcharoen

et al. 2009

Braz J Med Biol Res

View full text Add to dashboard Cite

Pueraria mirifica is a Thai phytoestrogen-rich herb traditionally used for the treatment of menopausal symptoms. Pueraria lobata is also a phytoestrogen-rich herb traditionally used in Japan, Korea and China for the treatment of hypertension and alcoholism. We evaluated the mutagenic and antimutagenic activity of the two plant extracts using the Ames test preincubation method plus or minus the rat liver mixture S9 for metabolic activation using Salmonella typhimurium strains TA98 and TA100 as indicator strains. The cytotoxicity of the two extracts to the two S. typhimurium indicators was evaluated before the mutagenic and antimutagenic tests. Both extracts at a final concentration of 2.5, 5, 10, or 20 mg/plate exhibited only mild cytotoxic effects. The plant extracts at the concentrations of 2.5, 5 and 10 mg/plate in the presence and absence of the S9 mixture were negative in the mutagenic Ames test. In contrast, both extracts were positive in the antimutagenic Ames test towards either one or both of the tested mutagens 2-(2-furyl)-3-(5-nitro-2-furyl)-acrylamide and benzo(a)pyrene. The absence of mutagenic and the presence of anti-mutagenic activities of the two plant extracts were confirmed in rec-assays and further supported by a micronucleus test where both plant extracts at doses up to 300 mg/kg body weight (equivalent to 16 g/kg body weight plant tuberous powder) failed to exhibit significant micronucleus formation in rats. The tests confirmed the non-mutagenic but reasonably antimutagenic activities of the two plant extracts, supporting their current use as safe dietary supplements and cosmetics.

show abstract

“…Herbal medicinal products are easily accessible and can be found at informal markets, pharmacies, health-food stores or bought online (3) . Even though the use of herbal remedies generally targets well-being there is an increased demand for immune and energy boosters, as well as detoxifi ers (4) . Herbal remedies are also used to treat various ailments (such as immune disorders, multidrug resistant microbial infections and carcinomas) due to the local abundance, cultural signifi cance and inexpensive procurement, when compared to Western pharmaceuticals (5) .…”

Section: Introductionmentioning

confidence: 99%

Drug interactions in African herbal remedies

Cordier

Steenkamp

2011

Dmdi

View full text Add to dashboard Cite

Herbal usage remains popular as an alternative or complementary form of treatment, especially in Africa. However, the misconception that herbal remedies are safe due to their "natural" origins jeopardizes human safety, as many different interactions can occur with concomitant use with other pharmaceuticals on top of potential inherent toxicity. Cytochrome P450 enzymes are highly polymorphic, and pose a problem for pharmaceutical drug tailoring to meet an individual's specific metabolic activity. The influence of herbal remedies further complicates this. The plants included in this review have been mainly researched for determining their effect on cytochrome P450 enzymes and P-glycoprotein drug transporters. Usage of herbal remedies, such as Hypoxis hemerocallidea, Sutherlandia frutescens and Harpagophytum procumbensis popular in Africa. The literature suggests that there is a potential for drug-herb interactions, which could occur through alterations in metabolism and transportation of drugs. Research has primarily been conducted in vitro, whereas in vivo data are lacking. Research concerning the effect of African herbals on drug metabolism should also be approached, as specific plants are especially popular in conjunction with certain treatments. Although these interactions can be beneficial, the harm they pose is just as great.

show abstract

Antimutagenic potential of the Thai herb, Mucuna collettii Lace

Cited by 11 publications

References 12 publications

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

Mutagenic and antimutagenic potentials of fruit juices of five medicinal plants in Allium cepa L.: Possible influence of DPPH free radical scavengers

The mutagenic and antimutagenic effects of the traditional phytoestrogen-rich herbs, Pueraria mirifica and Pueraria lobata

Drug interactions in African herbal remedies

Contact Info

Product

Resources

About