Antimutagenic properties of bell and black peppers

Hamss, Rachid El; Idaomar, Mohamed; Alonso-Moraga, Ángeles; Serrano, A Muñoz

doi:10.1016/s0278-6915(02)00216-8

Cited by 69 publications

(32 citation statements)

References 55 publications

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“…Externally, it is used as rubefacient and local application to relax throat inflammation and some skin diseases. It's also been assessed the antimicrobial property 7 and antimutagenic 8 . But the research on the antibacterial effect of white pepper is lacking.…”

Section: Introductionmentioning

confidence: 99%

White Pepper Extract (Piper nigrum L.) as Antibacterial Agent for Streptococcus mutans In Vitro

Sidarta¹

2013

IOSR-JDMS

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: Streptococcus mutans is a gram-positive bacterium in oral cavity which metabolism produces acid as the common cause of dental caries (tooth decay Result of the research indicates that Minimum Inhibitory Concentration (MIC) is found at concentration 10% of the white pepper extract, where as the Minimum Bactericidal Concentration (MBC) is found at concentration 12,5% of the extract. Data analysis is conducted with non parametric test of Kruskal Wallis. Kruskal Wallis test shows at least there is a difference of the number of colonies as the given concentration (p < 0,05). The correlation test of Spearman reveals a very strong reciprocal correlation between concentration of white pepper extract and the number of Streptococcus mutans colonies growth (Correlation,986; p < 0,05

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Section: Introductionmentioning

confidence: 99%

White Pepper Extract (Piper nigrum L.) as Antibacterial Agent for Streptococcus mutans In Vitro

Sidarta¹

2013

IOSR-JDMS

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“…4) Recent studies on pharmacological properties of bell pepper extracts and their constituents have shown several biological activities including antimutagenic, anticancer, and anti-inflammatory activities. [5][6][7] Since dietary products have the advantage of being safe and easy to take, we have investigated immunostimulating activities in crude extracts of various vegetables and fruits. In this study we found that the extract of red bell pepper flesh potently promoted polyclonal immunoglobulin M (IgM) production by murine B cells.…”

Section: Introductionmentioning

confidence: 99%

Enhancement of Immunoglobulin M Production in B Cells by the Extract of Red Bell Pepper

Goto

Sarker

Ming

et al. 2010

JOURNAL OF HEALTH SCIENCE

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Under immunocompromised conditions such as aging, cancer, diabetes, burns, and sepsis, external agents may be useful for upregulation of the immune system to prevent infection. Dietary products have the advantage of being safe and easy to take. An extract of red bell pepper (Capsicum annuum L.) flesh markedly enhanced immunoglobulin M (IgM) production by murine B cells and their proliferation. The effect of the extract on IgM production was not abrogated by treatment with polymyxin B and was also observed in spleen cells of lipopolysaccharideunresponsive C3H/HeJ mice. Treatment of B cells with the extract resulted in an increase in the number of IgMsecreting cells and cluster of differentiation (CD)138-positive cells. The IgM production-enhancing activity was resistant to trypsin treatment but was heat-labile. The activity was eluted in a peak with a molecular weight of 6000 on gel filtration. These results demonstrated that the extract of red bell pepper enhanced IgM production in B cells and suggest that the active substance(s) in the extract is a non-proteinous heat-labile macromolecule.

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“…The effect could also be attributed to certain molecules that are involved in these oils. El Hamss et al (2003) described the modulating action of bell pepper (Capsicum annuum) and black pepper (Piper nigrum) on the effects of the alkylating agent methyl methanesulfonate and the promutagen urethane when investigated using a D. melanogaster wing spot test. These authors concluding that suppression of metabolic activation or interaction with the active groups of mutagens could be mechanisms by which these spices exert their antimutagenic activity.…”

Section: Discussionmentioning

confidence: 99%

Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster

Silva

Sousa

Gräf³

et al. 2008

Genet. Mol. Biol.

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A Mandevilla velutina crude extract was investigated using the mouse micronucleus test (MNT) and the Drosophila melanogaster somatic mutation and recombination test (SMART) using standard (ST) and high bioactivation (HB) crosses. The MNT used 10 mg, 20 mg or 40 mg per 100 g of body weight (bw) of extract with and without 0.2 mg per 100 g bw peritoneal cyclophosphamide. There was no genotoxicity in the negative control or extract only groups and, compared to the cyclophosphamide control, there was a significant reduction in micronucleated polychromatic erythrocytes in all the groups given extract plus cyclophosphamide. For SMART larvae were fed 5 or 10 mg mL -1 of extract for seven days with and without 0.89 mg mL -1 of urethane given on day seven. The ST and HB flies showed no significant differences in spots between the negative control and the extract only groups. The number of urethane-induced spots was reduced by the highest concentration of extract for the ST flies and by both concentrations of extract for the HB flies. The results suggest that M. velutina extract is not genotoxic but is antigenotoxic.

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Antimutagenic properties of bell and black peppers

Cited by 69 publications

References 55 publications

White Pepper Extract (Piper nigrum L.) as Antibacterial Agent for Streptococcus mutans In Vitro

White Pepper Extract (Piper nigrum L.) as Antibacterial Agent for Streptococcus mutans In Vitro

Enhancement of Immunoglobulin M Production in B Cells by the Extract of Red Bell Pepper

Antigenotoxic effects of Mandevilla velutina (Gentianales, Apocynaceae) crude extract on cyclophosphamide-induced micronuclei in Swiss mice and urethane-induced somatic mutation and recombination in Drosophila melanogaster

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