Antimutagenicity of some citrus fruits in Salmonella typhimurium

Bala, Saroj; Grover, I. S.

doi:10.1016/0165-1218(89)90129-8

Cited by 42 publications

(17 citation statements)

References 9 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Citrus are one of the most extensively studied fruit crops because of their medicinal benefits against coronary diseases, chronic asthma, inflammation, tumors, and blood clotting (Alvarez et al 1986;Bala and Grover 1989;Choi et al 2002;Lagha-Benamrouche and Madani 2013). Epidemiological reports link the multiple medicinal properties of citrus to the presence of bioactive compounds such as phenolics, vitamin C, carotenoids, and flavonoids (Carmeli and Fogelman 2009;Abdillahi et al 2011).…”

Section: Introductionmentioning

confidence: 99%

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

Mushtaq¹,

Sultana²,

Bhatti³

et al. 2014

BioResources

View full text Add to dashboard Cite

Enzymatic treatment was used to induce liberation of antioxidant phenolics from under-utilized sweet lime peel (CLP). Small rotatable central composite design (SRCCD) was selected to optimize the conditions of enzymatic processing, i.e., enzyme concentration (2 to 5%), pH (5 to 8), temperature (30 to 75 °C), and incubation time (30 to 120 min). The morphological characterization of enzymatically hydrolyzed CLP was performed using field emission scanning electron microscopy (FESEM). Extracts obtained under suitable conditions were characterized for their phenolic profile by use of reverse-phase high-performance liquid chromatography coupled with a diode array detector (RP-HPLC-DAD) and evaluated for in vitro antioxidant activities. The observed results revealed that optimum enzymatic pre-treatment doubled the recovery of phenolic antioxidants with maximum Trolox equivalent antioxidant capacity (TEAC) and 2,2-diphenyl-1-picrylhydrazyl (DPPH) radical scavenging potential (IC50). The observed results indicate that enzyme-assisted extraction might be a green choice to revalorize agro-processing residues.

show abstract

Section: Introductionmentioning

confidence: 99%

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

Mushtaq¹,

Sultana²,

Bhatti³

et al. 2014

BioResources

View full text Add to dashboard Cite

show abstract

“…There are several ways in which mutagenesis by direct acting mutagens can be reduced or prevented; MNU is decomposed to non-mutagenic products, or the decomposition of MNU to reactive electrophile is accelerated while the electrophile reacts to other nucleophile before reaching DNA extra-or intra cellularly (38). Another possibility is to induce the repair enzyme in Salmonella strain (37). Glycyrrhiza Root ethanolic extract has been suggested not just to be desmutagenic in their antimutagenicity on EMS (44).…”

Section: Discussionmentioning

confidence: 99%

“…The assay has lots of advantages as an inexpensive and ‰exible screen-ing which provides preliminary information on antimutagenesis. There are many reports about the antimutagenicity of herbal medicines (30)(31)(32), vegetables and fruits (33)(34)(35)(36)(37)(38)(39). Many studies have employed indirect acting mutagens (30)(31)(32)(33)(34)(35)39) and direct acting mutagens; N-methyl-N?-nitro-N-nitrosoguanidine (MNNG), ethyl methanesulfonate (EMS) (35,(37)(38)(39), while MNU was less studied (38,39).…”

Section: Introductionmentioning

confidence: 99%

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

Tatsuzaki¹,

Yang²,

Kojo

et al. 2014

Genes and Environment

View full text Add to dashboard Cite

N-Nitroso compounds are suspected to be causative agents for human cancer. N-Methyl-N-nitrosourea (MNU) is a typical direct acting mutagen with alkylation activity of DNA, and has been reported to be formed in vivo. Therefore, it is important for cancer chemoprevention toˆnd some compounds to inhibit mutagenicity induced by MNU. The inhibitory eŠect of plant extracts against the mutagenicity of MNU was evaluated using the Ames assay with Salmonella typhimurium TA1535. Among 43 extracts derived from medicinal and edible plant assayed, Glycyrrhiza aspera ethanolic extract, Glycine max extract with 40% iso‰avone aglycone (ISOMAX AG40) and Zingiber o‹cinale ethanolic extract at the range 0.01-1.0 mg/plate inhibited MNU-induced mutagenicity in S. typhimurium TA1535. No cytotoxicity of the three extracts were observed in Salmonella typhimuirum TA1535, indicating that inhibition of MNU-induced mutagenicity was apparently due to the antimutagenic potency of Glycyrrhiza aspera ethanolic extract, ISOMAX AG40 and Zingiber o‹cinale ethanolic extract. Therefore, the results of relative mutagenicity showed that Glycyrrhiza aspera ethanolic extract and ISOMAX AG40 decreased the mutagenic eŠects to 5.4% and 2.6%, respectively, whereas Zingiber o‹cinale ethanolic extract decreased it to 45%.

show abstract

“…Indeed, the transposition of information from food content to chemical properties to biological effects is complex. To investigate any association between the experimental data and the mutagenic activity of food items, we compiled data on mutagens in foods assayed with the Ames test without the inclusion of a bioactivating system (see supplementary data) (22)(23)(24)(25)(26)(27)(28). Several of the foods high in GRU were also positive, whereas many of the foods with highly negative net GRU levels were protective in assays with known mutagens.…”

Section: Discussionmentioning

confidence: 99%

Total Equivalent of Reactive Chemicals in 142 Human Food Items Is Highly Variable Within and Between Major Food Groups

Openo

McCullough

et al. 2004

The Journal of Nutrition

View full text Add to dashboard Cite

Many reactive electrophilic chemicals (e.g., acrylamide and hydrazine) occur in foods, and these could individually or cumulatively contribute to human cancer or other diseases. Glutathione (GSH) reacts with and detoxifies electrophilic compounds and is used physiologically to protect against a broad range of toxic and mutagenic compounds. To elucidate the distribution of reactive chemicals in foods, we added a known amount of GSH to 142 commonly consumed food items and assayed the relative amounts of reactive chemicals in terms of the amount of GSH lost during homogenization and extraction, defined quantitatively in terms of glutathionereactive units (GRUs). Thirty-four items contained GRUs but no detectable GSH; 53 items contained both GSH and GRUs; 18 items contained no GSH or GRUs; and 37 items contained GSH but no detectable GRUs. Among the food groups, cereals, bread, milk, and milk products had relatively high GRU concentrations and low GSH concentrations; several common beverages also had high GRU concentrations and low GSH concentrations; meats and main course dishes were generally low in GRUs and high in GSH. Fruits and vegetables varied in GRU concentration, but most fresh fruits and vegetables had considerably more GSH than GRUs; exceptions were canned vegetables, which had no GSH or GRUs; fruit drinks, which had moderate levels of GRUs and no GSH; and 3 fruits (blueberries, cherries, and prunes), which had high GRU levels. The results provide a database that can be used with food frequency analyses to evaluate the possible association of health risks with the consumption of foods high in GSH-reactive chemicals.

show abstract

Antimutagenicity of some citrus fruits in Salmonella typhimurium

Cited by 42 publications

References 9 publications

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

Optimization of Enzyme-assisted Revalorization of Sweet Lime (Citrus limetta Risso) Peel into Phenolic Antioxidants

Antimutagenicity Screening of Extracts from Medicinal and Edible Plants against N-Methyl-N-nitrosourea by the Ames Assay

Total Equivalent of Reactive Chemicals in 142 Human Food Items Is Highly Variable Within and Between Major Food Groups

Contact Info

Product

Resources

About