Antimycins, Inhibitors of ATP-Citrate Lyase, from a Streptomyces sp.

Barrow, Colin J.; Oleynek, Joseph J.; Marinelli, Vincent; Sun, Hao H.; Kaplita, Paul V.; Sedlock, David M.; Gillum, Amanda M.; Chadwick, Christopher C.; Cooper, Raymond

doi:10.7164/antibiotics.50.729

Cited by 55 publications

(34 citation statements)

References 7 publications

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“…As antimycin structures differ from each other by the length and branching of their alkyl and acyl chains, their structures were determined through interpretation of HRMS and by comparison to reported 1 H NMR data 9–11…”

Section: Resultsmentioning

confidence: 99%

Potent Inhibitors of Pro-Inflammatory Cytokine Production Produced by a Marine-Derived Bacterium

et al. 2009

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Cytokines produced through the Antigen Presenting Cell (APC)-T-cell interaction play a key role in the activation of the allergic asthmatic response. Evaluating small molecules that inhibit the production of these pro-inflammatory proteins is therefore important for the discovery of novel chemical structures with potential anti-asthma activity. We adapted a mouse splenocyte cytokine assay to screen a library of 2,500 marine microbial extracts for their ability to inhibit T H 2 cytokine release and identified potent activity in a marine-derived strain CNQ431, identified as a Streptomyces species. Bioactivity guided fractionation of the organic extract of this strain led to the isolation of ten new 9-membered bis-lactones, splenocins A-J (1-10). The new compounds display potent biological activities, comparable to that of the corticosteroid dexamethasone, with IC 50 values from 2-50 nanomolar in the splenocyte cytokine assay. This study provides the foundation for the optimization of these potent anti-inflammatory compounds for development in the treatment of asthma.

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Section: Resultsmentioning

confidence: 99%

Potent Inhibitors of Pro-Inflammatory Cytokine Production Produced by a Marine-Derived Bacterium

et al. 2009

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“…Antimycins act by inhibiting the electron flow in the mitochondrial respiratory chain [47]. Antimycins have been previously identified in Streptomyces isolated from the integument of attine ants [32–34].…”

Section: Resultsmentioning

confidence: 99%

“…with MIC values equivalent to the antifungal nystatin, which indicates the potential for medical use. For many years, antimycins were used for the treatment of human infections, but due to its mechanism of action and associated side effects, its use in human treatment was discontinued [47]. However, with the pressing need for new antifungal agents that complement or substitute for the scarce products available on the market, it is interesting and necessary to determine the toxicity presented by urauchimycin B, to assess whether it can be used as an antifungal agent for humans and animals.…”

Section: Resultsmentioning

confidence: 99%

Anti-CandidaProperties of Urauchimycins from Actinobacteria Associated withTrachymyrmexAnts

Mendes

Borges

Rodrigues

et al. 2013

BioMed Research International

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After decades of intensive searching for antimicrobial compounds derived from actinobacteria, the frequency of isolation of new molecules has decreased. To cope with this concern, studies have focused on the exploitation of actinobacteria from unexplored environments and actinobacteria symbionts of plants and animals. In this study, twenty-four actinobacteria strains isolated from workers of Trachymyrmex ants were evaluated for antifungal activity towards a variety of Candida species. Results revealed that seven strains inhibited the tested Candida species. Streptomyces sp. TD025 presented potent and broad spectrum of inhibition of Candida and was selected for the isolation of bioactive molecules. From liquid shake culture of this bacterium, we isolated the rare antimycin urauchimycins A and B. For the first time, these molecules were evaluated for antifungal activity against medically important Candida species. Both antimycins showed antifungal activity, especially urauchimycin B. This compound inhibited the growth of all Candida species tested, with minimum inhibitory concentration values equivalent to the antifungal nystatin. Our results concur with the predictions that the attine ant-microbe symbiosis may be a source of bioactive metabolites for biotechnology and medical applications.

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“…According to used software we identified active compounds by comparison of molecular weights, UV spectra, and retention times like Urauchimycin A and Kitamycin A. Kitamycin A and Urauchimycin A belong to the antimycin class, a group of well-known antifungals. Antimycins act by inhibiting the electron flow in the mitochondrial respiratory chain (Barrow et al 1997). Urauchimycins A and B were previously isolated from Streptomyces sp.…”

Section: Fig 1 Identification Of Active Metabolites From Strain Vy46mentioning

confidence: 99%

“…The antimycins are forming a group of about 30 closely related lactolide antibiotics 9 . The antimycins differ in the nature of their alkyl residue at C-7 and of the oxygen substituent at C-8: Acylation of the 8-hydroxy group modulates the strong antifungal, antiviral and antitumor activities 10 .Production of antimycinantibiotics were confirmed in differentstreptomycete strains 11,12,13 .…”

Section: Introductionmentioning

confidence: 99%

Characterization of Antimycins – Producing Streptomycete Strain VY46 Isolated from Slovak Soil

Charousová

Steinmetz

Medo

et al. 2016

Braz. arch. biol. technol.

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Antimycins, Inhibitors of ATP-Citrate Lyase, from a Streptomyces sp.

Cited by 55 publications

References 7 publications

Potent Inhibitors of Pro-Inflammatory Cytokine Production Produced by a Marine-Derived Bacterium

Potent Inhibitors of Pro-Inflammatory Cytokine Production Produced by a Marine-Derived Bacterium

Anti-CandidaProperties of Urauchimycins from Actinobacteria Associated withTrachymyrmexAnts

Characterization of Antimycins – Producing Streptomycete Strain VY46 Isolated from Slovak Soil

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