Antimycobacterial Activity of Isoniazid + Prothionamide + Dapsone against a Number of Randomly Selected ‘Wild’ Strains of &lt;i&gt;Mycobacterium tuberculosi&lt;/i&gt;&lt;i&gt;s&lt;/i&gt;

Urbanczik, R

doi:10.1159/000237917

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Combinations and Alternative Medications Are Imperative In L1

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1982

1989

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“…Besides, the synergistic effects of the drugs can be practically exploited. In this way, qualitatively new chemotherapeutical effects can be obtained [9,21,22,25,33,[36][37][38][39][40][45][46][47].…”

Section: Combinations and Alternative Medications Are Imperative In Lmentioning

confidence: 99%

New Forms of Multidrug Therapy for the Treatment of Leprosy

Freerksen¹,

Rosenfeld²,

Spannuth³

1989

Chemotherapy

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Since 1970, when the lifelong monotherapy with dapsone (DDS) in leprosy could be replaced by short-term combination therapy with rifampicin + isoniazid + protionamide-!-DDS (Isoprodian-RMP), chemotherapeutic research was faced with two problems: (1) to find alternative treatment regimens for cases of intolerance, and (2) to work out forms of therapy allowing a further reduction of the average treatment time of 2 years. The present paper describes the attempts made to find solutions to these problems. With two new combinations, alternatives have become available, and the average treatment time is shortened to 6 months. Both combinations are also effective in tuberculosis.

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