Antimycobacterial Activity of Some Commercially Available Plant-Derived Essential Oils

Alves, J.A.; Mantovani, André Luis Lembi; Martins, Moara Helena Garcia; Abrão, Fariza; Lucarini, Rodrigo; Crotti, Antônio Eduardo Miller; Martins, Carlos Henrique Gomes

doi:10.1007/s10600-015-1281-0

Cited by 11 publications

(9 citation statements)

References 12 publications

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“…As part of our ongoing research on the antimicrobial activities of essential oils [ 1 , 17 – 19 ], in this work, we used the broth microdilution method to evaluate the in vitro antimicrobial activity of the essential oil obtained from the leaves of Plectranthus neochilus (Lamiaceae) against a representative panel of cariogenic bacteria.…”

Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of the Essential Oil ofPlectranthus neochilusagainst Cariogenic Bacteria

Crevelin

Caixeta

Dias

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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This work used the broth microdilution method to investigate the antimicrobial activity of the essential oil obtained from the leaves of Plectranthus neochilus (PN-EO) against a representative panel of oral pathogens. We assessed the antimicrobial activity of this oil in terms of the minimum inhibitory concentration (MIC). PN-EO displayed moderate activity against Enterococcus faecalis (MIC = 250 μg/mL) and Streptococcus salivarus (MIC = 250 μg/mL), significant activity against Streptococcus sobrinus (MIC = 62.5 μg/mL), Streptococcus sanguinis (MIC = 62.5 μg/mL), Streptococcus mitis (MIC = 31.25 μg/mL), and Lactobacillus casei (MIC = 31.25 μg/mL), and interesting activity against Streptococcus mutans (MIC = 3.9 μg/mL). GC-FID and GC-MS helped to identify thirty-one compounds in PN-EO; α-pinene (1, 14.1%), β-pinene (2, 7.1%), trans-caryophyllene (3, 29.8%), and caryophyllene oxide (4, 12.8%) were the major chemical constituents of this essential oil. When tested alone, compounds 1, 2, 3, and 4 were inactive (MIC > 4000 μg/mL) against all the microorganisms. These results suggested that the essential oil extracted from the leaves of Plectranthus neochilus displays promising activity against most of the evaluated cariogenic bacteria, especially S. mutans.

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Section: Introductionmentioning

confidence: 99%

Antimicrobial Activity of the Essential Oil ofPlectranthus neochilusagainst Cariogenic Bacteria

Crevelin

Caixeta

Dias

et al. 2015

Evidence-Based Complementary and Alternative Medicine

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“…Therefore, the antimycobacterial activity of essential oils from M. paniculata (L.) Jack unripe and ripe fruits against Mycobaterium tuberculosis, M. kansasii and M. avium was investigated by determining minimum inhibitory concentrations (MICs , Table III). The literature reports that essential oils with MIC values of 500 µg/mL and 250 µg/mL are considered moderately active and active, respectively, whereas values from 1000 to 2000 µg/mL are poorly active against mycobacteria under evaluation (Alves et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…Besides, there has been significant increase in the number of nontuberculous mycobacteria, such as Mycobacterium kansasii and M. avium, which also affect the lungs, lymph, skin and joints. Resulting diseases may produce severe after-effects if they are not properly treated (Alves et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus

Silva

Fernandes

Santiago

et al. 2020

Braz. J. Pharm. Sci.

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This study aims to investigate chemical composition of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits and determine their in vitro antibacterial activity. Essential oils were extracted by hydrodistillation from Murraya paniculata (L.) Jack ripe and unripe fruits collected in the Cerrado, in Rio Verde, southwestern Goiás, Brazil. They were analyzed by gas chromatography with flame ionization detector (GC-FID) and by gas chromatography-mass spectrometry (GC-MS). Sesquiterpenes, which represent the most abundant class of compounds in oils, predominated in both ripe and unripe fruits. Major constituents of essential oils extracted from ripe fruits (RF-EO) were β-caryophyllene (21.3%), α-ylangene (13.3%), germacrene-D (10.9%) and α-zingiberene (9.7%) whereas the ones of unripe fruits (UF-EO) were sesquithujene (25.0%), α-zingiberene (18.2%), germacrene-D (13.1%) and α-copaene (12.7%). In vitro antibacterial activity of essential oils was evaluated in terms of its minimum inhibitory concentration (MIC) values by the broth microdilution method in 96-well microplates. Both essential oils under investigation showed moderate anti-streptococcal activity against the following bacteria: Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus and S. salivarius. MIC values ranged between 100 and 400 µg/mL. Regarding the antimycobacterial activity, essential oils from M. paniculata (L.) Jack unripe and ripe fruits were active against Mycobacterium kansasii (MIC = 250 µg/mL), moderately active against M. tuberculosis (MIC = 500 µg/mL) and inactive against M. avium (MIC = 2000 µg/mL). This study was pioneer in revealing similar chemical profiles of both essential oils extracted from Murraya paniculata (L.) Jack unripe and ripe fruits, besides describing their in vitro anti-streptococcal and antimycobacterial activities.

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“…The constituent α-bisabolol was highly active against M. tuberculosis (MIC = 20 μg/mL) and active against M. kansasii and M. avium (MIC = 150 μg/mL). The literature reports that EOs whose MIC values are 500 µg/mL and 250 µg/mL are considered moderately active and active, respectively, whereas values from 1000 to 2000 µg/mL show that they are poorly active against mycobacteria under evaluation (Alves et al, 2015).…”

Section: Resultsmentioning

confidence: 99%

“…Tuberculosis, which is caused by Mycobacterium tuberculosis, has been the major infectious and contagious disease of bacterial origin in the world, since it accounts for the death of two million people a year (Wang et al, 2010). In addition to M. tuberculosis, other nontuberculous mycobacteria, such as M. avium and M. kansasii, are also important because they affect lungs, lymph, skin and joints and lead to severe sequels if not treated properly (Alves et al, 2015). Plants have always been considered sources of effective chemotherapeutic agents against several infectious diseases.…”

Section: Introductionmentioning

confidence: 99%

In vitro evaluation of anticaries, antimycobacterial, antileishmanial and cytotoxic activities of essential oils from Eremanthus erythropappus and of α-bisabolol, their major sesquiterpene

et al. 2020

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Interest in researches into medicinal plants and therapeutic effects of essential oils (EOs) on humans has increased over the last few years. Eremanthus erythropappus, known as candeia, is a Brazilian aromatic herbaceous plant whose α-bisabolol-rich oil has been used in several cosmetic preparations. This paper reports in vitro anticaries, antimycobacterial, antileishmanial and cytotoxic activities of EOs from E. erythropappus leaves (EL-EO) and stalks (ES-EO), besides α-bisabolol, their main sesquiterpene. EL-EO and ES-EO were extracted by hydrodistillation and analyzed by GC-FID and GC-MS. α-Bisabolol, cis-α-bisabolene and β-bisabolene were identified as their major constituents. Antibacterial activity of EOs was evaluated against eight standard strains of pathogens from the American Type Culture Collection (ATCC) by determining minimum inhibitory concentrations (MICs) with the use of the microdilution method. Antibacterial activity was evaluated against Streptococcus mutans, S. mitis, S. sanguinis, S. sobrinus, S. salivarius, Mycobacterium tuberculosis, M. avium and M. kansasii. EL-EO, ES-EO and α-bisabolol exhibited high leishmanicidal activity against promastigote forms of Leishmania amazonensis; IC50 values were 9.22 µg/mL, 6.00 µg/mL and 3.12 µg/mL, respectively. The 50% cytotoxic concentrations (CC50) of EL-EO, ES-EO and α-bisabolol against mouse peritoneal macrophages were 24.65 µg/mL, 8.87 µg/mL and 1021.00 µg/mL, respectively. These results suggest that EOs from E. erythropappus seem to be very promising for the development of new bactericidal and leishmanicidal agents.

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Antimycobacterial Activity of Some Commercially Available Plant-Derived Essential Oils

Cited by 11 publications

References 12 publications

Antimicrobial Activity of the Essential Oil ofPlectranthus neochilusagainst Cariogenic Bacteria

Antimicrobial Activity of the Essential Oil ofPlectranthus neochilusagainst Cariogenic Bacteria

Chemical composition and in vitro antibacterial activity of essential oils from Murraya paniculata (L.) Jack (Rutaceae) ripe and unripe fruits against bacterial genera Mycobacterium and Streptococcus

In vitro evaluation of anticaries, antimycobacterial, antileishmanial and cytotoxic activities of essential oils from Eremanthus erythropappus and of α-bisabolol, their major sesquiterpene

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