Antimycobacterial and anti-oxidant potential of the bioactive metabolite isolated from the endophytic fungus Daldinia eschscholtzii

Shylaja, Gunasekaran; Sasikumar, Kandasamy; Arunachalam, S.

doi:10.3329/bjp.v13i4.38593

Cited by 3 publications

(1 citation statement)

References 11 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…From the marine algicolous strain of D.eschscholzii, Tarman et al [8] obtained a new lactone helicascolide C (13, Figure 2). From medical plants, Shylaja et al [9] isolated D.eschscholtzii from Mussaenda luteola and purified compound 5-methoxy-2methyl-3-pentacosyl-1,4-benzoquinone (14). From the mangrove endophytic fungus D.eschscholtzii HJ001, Yang et al [10] obtained a new cytochalasin (15).…”

Section: Natural Products Of Various Species Of the Genus Daldiniamentioning

confidence: 99%

Natural Products from the genus Daldinia and Their Bioactivities

2021

Med. Res.

View full text Add to dashboard Cite

Section: Natural Products Of Various Species Of the Genus Daldiniamentioning

confidence: 99%

Natural Products from the genus Daldinia and Their Bioactivities

2021

Med. Res.

View full text Add to dashboard Cite

Antioxidant and L-asparaginase activities of culturable endophytic fungi from ornamental Dendrobium orchids

Chua,

Song,

Ting

2023

Letters in Applied Microbiology

View full text Add to dashboard Cite

This study reports the antioxidant potential and L-asparaginase production of culturable fungal endophytes from Dendrobium orchids in Malaysia. Twenty-nine isolates were screened using the 2,2-diphenyl-1-picrylhydrazyl (DPPH) assay to determine their free radical scavenging activities and antioxidant capacity (IC50 and AEAC). L-asparaginase production of fungal endophytes was detected by the qualitative plate assay and the enzyme activities estimated via the Nesslerization method. All 29 endophytic isolates exhibited various degrees of radical scavenging activities (35.37 to 77.23%), with Fusarium fujikuroi (D1) identified as having the highest antioxidant capacity (IC50 6.097 mg/mL) and the highest AEAC value (11.55 mg/g). For L-asparaginase production, the majority of the isolates (89.66%) showed positive results especially among the culturable species of Fusarium, Trichoderma and Daldinia. Most Fusarium spp. were able to produce L-asparaginase (80.77%) but the highest L-asparaginase activity was detected in Daldinia eschscholtzii (D14) with 2.128 unit/mL. Results from this study highlighted the potential of endophytic fungi from medicinal orchids (Dendrobium sp.) as natural sources of bioactive compounds to be developed into novel antioxidants and anticancer drugs.

show abstract

Unveiling the potential of Daldinia eschscholtzii MFLUCC 19-0629 through bioactivity and bioinformatics studies for enhanced sustainable agriculture production

Brooks,

Weaver,

Klomchit

et al. 2024

Front. Chem. Biol.

View full text Add to dashboard Cite

Endophytic fungi constitute a rich source of secondary metabolites that can be manipulated to produce desirable novel analogs for combating current agricultural challenges for crop production, especially controlling plant disease. The endophytic fungus Daldinia eschscholtzii MFLUCC 19-0629, was newly isolated from tropical ancient plants, Oncosperma sp., and displays a broad-spectrum of antifungal and antibacterial activities against several plant pathogens including Ralstonia solanacearum, Fusarium oxysporum, Colletotrichum gloeosporioides, Colletotrichum acutatum, Stagonosporopsis cucurbitacearum, Corynespora cassiicola and Stemphylium spp. A high-quality genome sequence was obtained using Oxford nanopore technology, the accuracy and length of reads resulting in no need for Illumina or other sequencing techniques, for D. eschscholtzii MFLUCC 19-0629, resulting in a genome size of 37.56 Mb assembled over 11 contigs of significant size, likely to be at the chromosomal level. Bioinformatics analysis revealed that this strain is biosynthetically talented encoding 67 predicted biosynthetic gene clusters (BGCs). Only eight of the 67 BGCs matched or demonstrated high similarity to previously characterized BGCs linked to the production of known secondary metabolites. The high number of predicted unknown BGCs makes this strain a promising source of novel natural products. The discovery that D. eschscholtzii MFLUCC 19-0629 has a broad spectrum of antimicrobial activity against seven major plant pathogenic microorganisms relevant to crop production and its complete genome sequence carries immense importance in the advancement of novel microbial biocontrol agents (MBCAs). This also unveils the prospect of uncovering new compounds that could be utilized for sustainable agriculture and pharmaceutical purposes.

show abstract

Antimycobacterial and anti-oxidant potential of the bioactive metabolite isolated from the endophytic fungus Daldinia eschscholtzii

Cited by 3 publications

References 11 publications

<p class="Author"> <p class="Title" style="text-indent:0mm;"> Natural Products from the genus <i>Daldinia</i> and Their Bioactivities

<p class="Author"> <p class="Title" style="text-indent:0mm;"> Natural Products from the genus <i>Daldinia</i> and Their Bioactivities

Antioxidant and L-asparaginase activities of culturable endophytic fungi from ornamental Dendrobium orchids

Unveiling the potential of Daldinia eschscholtzii MFLUCC 19-0629 through bioactivity and bioinformatics studies for enhanced sustainable agriculture production

Contact Info

Product

Resources

About